Development of a verified osteoarthritis risk scale based on a cross-sectional study of clinical and anamnestic parameters and pharmacological anamnesis of patients
I. Yu. Torshin,
А. М. Lila,
N. V. Zagorodniy,
А. G. Nazarenko,
О. N. Tkacheva,
Е. N. Dudinskaya,
L. I. Alekseeva,
Е. А. Taskina,
I. V. Sarvilina,
О. А. Shavlovskaya,
A. B. Danilov,
Т. B. Minasov,
А. N. Galustyan,
S. I. Malyavskaya,
А. N. Gromov,
Е. Yu. Egorova,
L. V. Vasilyeva,
E. F. Evstratova,
I. V. Gogoleva,
L. E. Fedotova,
М. I. Udovika,
V. A. Maximov,
А. S. Povzun,
О. А. Gromova https://doi.org/10.17749/2070-4909/farmakoekonomika.2023.158
Abstract
Objective: the development and verification of a scale for identifying patients at high risk of osteoarthritis (OA).
Material and methods. The results of the analysis of a sample of patients aged 35–90 years from the database of the Institute of Trace Elements (n=3440), which included information on clinical and anamnestic, diagnostic parameters and pharmacotherapy of patients, including patients with OA (n=107), are presented. To analyze information about patients, modern methods of data analysis proposed within the topological theory of pattern recognition were used.
Results. Based on the analysis of the sample, a 100-point scale of 27 points was developed which allows to identify patients at high risk of OA (sensitivity 88%, specificity 100%). For patients with high scores on the scale, a kind of “preemptive” prescription of symptomatic slowacting drugs for osteoarthritis (SySADOA) based on highly purified substances of chondroitin sulfate (CS) and glucosamine sulfate (GS) is promising. The evidence for CS/GS is extensive and has been reviewed previously.
Conclusion. Early adoption of preventive measures (including the usage of SySADOA – CS/GS) in patients with a high score on the developed scale may reduce the risk of OA.
Keywords
osteoarthritis,
joint pathology,
osteoarthritis risk assessment scale,
osteoarthritis prevention,
symptomatic slow-acting drugs for osteoarthritis,
SySADOA,
topological recognition theory
Supporting agencies: The research was conducted under the government contract No. 0063-2019-0003 “Mathematical methods of data analysis and forecasting” using the infrastructure of the Shared Research Facilities “High Performance Computing and Big Data” of Federal Research Center “Informatics and Management”, Russian Academy of Sciences (Moscow).
About the Authors
I. Yu. Torshin
Federal Research Center “Computer Science and Control”, Russian Academy of Sciences
Russian Federation
Russian Federation
Ivan Yu. Torshin – PhD (Phys. Math.), PhD (Chem.), Senior Researcher
Scopus Author ID: 7003300274; WoS ResearcherID: C-7683-2018
4 Vavilov Str., Moscow 211933
А. М. Lila
Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Aleksandr M. Lila – Dr. Med. Sc., Professor, Director
Scopus Author ID: 6602550827; WoS ResearcherID: W-3334-2017
34А Kashirskoye Shosse, Moscow 115522
N. V. Zagorodniy
Priorov National Medical Research Center of Traumatology and Orthopedics
Russian Federation
Russian Federation
Nikolay V. Zagorodniy – Dr. Med. Sc., Corresponding Member of RAS, Professor, Chair of Traumatology and Orthopedics, Head of Joint Replacement Clinic
10 Priorov Str., Moscow 127299
А. G. Nazarenko
Priorov National Medical Research Center of Traumatology and Orthopedics
Russian Federation
Russian Federation
Anton G. Nazarenko – Dr. Med. Sc., Professor of RAS, Director
10 Priorov Str., Moscow 127299
О. N. Tkacheva
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Olga N. Tkacheva – Dr. Med. Sc., Professor, Corresponding Member of RAS, Head of Russian Gerontology Research and Clinical Centre
WoS ResearcherID: M-4510-2014
1 Ostrovityanov Str., Moscow 117513
Е. N. Dudinskaya
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Ekaterina N. Dudinskaya – Dr. Med. Sc., Head of Age-Related Metabolic and Endocrine Disorders Laboratory, Russian Gerontology Research and Clinical Centre
WoS ResearcherID: AAI-4271-2021
1 Ostrovityanov Str., Moscow 117513
L. I. Alekseeva
Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Lyudmila I. Alekseeva – Dr. Med. Sc., Head of Department of Metabolic Diseases of Bones and Joints with the Center for Prevention of Osteoporosis
34А Kashirskoye Shosse, Moscow 115522
Е. А. Taskina
Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
Elena A. Taskina – MD, PhD, Senior Researcher, Laboratory of Osteoarthritis, Department of Metabolic Diseases of Bones and Joints with the Center for Prevention of Osteoporosis
34А Kashirskoye Shosse, Moscow 115522
I. V. Sarvilina
Medical Centre “Novomeditsina”
Russian Federation
Russian Federation
Irina V. Sarvilina – Dr. Med. Sc., Clinical Pharmacologist, Chief Physician
74 Sotsialisticheskaya Str., Rostov-on-Don 344002
О. А. Shavlovskaya
International University of Restorative Medicine
Russian Federation
Russian Federation
Olga A. Shavlovskaya – Dr. Med. Sc., Professor, Chair of Organization of Medical Rehabilitation and Sanatorium Treatment
WoS ResearcherID: V-4470-2018; Scopus Author ID: 15124744300
8/2 Furmannyy Aly, Moscow 105062
A. B. Danilov
Sechenov University
Russian Federation
Russian Federation
Alexey B. Danilov – Dr. Med. Sc., Chief of Chair of Nervous Diseases, Institute of Professional Education
WoS ResearcherID: AAO-8351-2021; Scopus Author ID: 16734010700
8/2 Trubetskaya Str., Moscow 119991
Т. B. Minasov
Bashkir State Medical University
Russian Federation
Russian Federation
Timur B. Minasov – Dr. Med. Sc., Professor, Chair of Traumatology and Orthopedics with the course of the Institute of Additional Professional Education
Scopus Author ID: 17346255400
3 Lenin Str., Ufa 450008
А. N. Galustyan
Saint Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Anna N. Galustyan – MD, PhD, Associate Professor, Chief of Chair of Pharmacology with a Course in Clinical Pharmacology and Pharmacoeconomics
2 Litovskaya Str., Saint Petersburg 194100
S. I. Malyavskaya
Northern State Medical University
Russian Federation
Russian Federation
Svetlana I. Malyavskaya – Dr. Med. Sc., Professor, Vice-Rector for Science
WoS ResearcherID: L-6642-2017; Scopus Author ID: 16304646300
51 Troitskiy Ave., Arkhangelsk 163000
А. N. Gromov
Federal Research Center “Computer Science and Control”, Russian Academy of Sciences
Russian Federation
Russian Federation
Andrey N. Gromov – Research Engineer
Scopus Author ID: 7102053964; WoS ResearcherID: C-7476-2018
4 Vavilov Str., Moscow 211933
Е. Yu. Egorova
Ivanovo State Medical Academy
Russian Federation
Russian Federation
Evgenia Yu. Egorova – MD, PhD, Associate Professor, Chair of Life Safety and General Medical Knowledge
8 Sheremetevskiy Ave., Ivanovo 153012
L. V. Vasilyeva
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Lyudmila V. Vasilieva – Dr. Med. Sc., Professor, Chief of Chair of Propaedeutics of Internal Diseases
10 Studencheskaya Str., Voronezh 394036
E. F. Evstratova
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Elizaveta F. Evstratova – Dr. Med. Sc., Associate Professor, Assistant Professor, Chair of Propaedeutics of Internal Diseases
10 Studencheskaya Str., Voronezh 394036
I. V. Gogoleva
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Irina V. Gogoleva – MD, PhD, Associate Professor, Chair of Pharmacology and Clinical Pharmacology
Scopus Author ID: 35773149200
10 Studencheskaya Str., Voronezh 394036
L. E. Fedotova
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Lyubov E. Fedotova – MD, PhD, Associate Professor, Chair of Pharmacology and Clinical Pharmacology
10 Studencheskaya Str., Voronezh 394036
М. I. Udovika
Medical and Sanitary Unit of the Ministry of Internal Affairs of the Russian Federation in the Ulyanovsk Region
Russian Federation
Russian Federation
Maya I. Udovika – Rheumatologist
17 Orlov Str., Ulyanovsk 432071
V. A. Maximov
Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Valeriy А. Maximov – Dr. Med. Sc., Professor, Chair of Dietetics and Nutritionology
2/1 bldg 1 Barrikadnaya Str., Moscow 123242
А. S. Povzun
Sokolov North-Western District Scientific and Clinical Center, Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Anton S. Povzun – MD, PhD, Associate Professor, Chief Physician, Valdai Multidisciplinary Medical Center
Scopus Author ID: 56769727500
4 Culture Ave., Saint Petersburg 194291
О. А. Gromova
Federal Research Center “Computer Science and Control”, Russian Academy of Sciences
Russian Federation
Russian Federation
Olga A. Gromova – Dr. Med. Sc., Professor, Research Supervisor, Institute of Pharmacoinformatics
Scopus Author ID: 7003589812; WoS ResearcherID: J-4946-2017
4 Vavilov Str., Moscow 211933
References
1. Global Burden of Disease Study 2019. Latest GBD results: 2019. Available at: https://www.healthdata.org/gbd/gbd-2019-resources (accessed 12.10.2021).
2. Torshin I.Yu., Lila A.M., Naumov A.V., et al. Perspectives of osteoarthritis prevention and therapy personification based on the analysis of comorbid background, genetic polymorphisms and microelement status. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2021; 14 (1): 28–39 (in Russ.). https://doi.org/10.17749/2070-4909/farmakoekonomika.2021.077.
3. Nukala S., Puvvada S.R., Luvsannyam E., et al. Hyperlipidemia and statin use on the progression of osteoarthritis: a systematic review. Cureus. 2021; 13 (6): e15999. https://doi.org/10.7759/cureus.15999.
4. Torshin I.Yu., Rudakov K.V. On the theoretical basis of the metric analysis of poorly formalized problems of recognition and classification. Pattern Recognit Image Anal. 2015; 25 (4): 577–87. https://doi.org/10.1134/S1054661815040252.
5. Limanova O.A., Torshin I.Yu., Sardaryan I.S., et al. Micronutrient provision and women''s health: intellectual analysis of clinicoepidemiological data. Gynecology, Obstetrics and Perinatology. 2014; 13 (2): 5–15 (in Russ.).
6. Torshin I.Yu., Rudakov K.V. On the procedures of generation of numerical features over partitions of sets of objects in the problem of predicting numerical target variables. Pattern Recognit Image Anal. 2019; 29 (4): 654–67. https://doi.org/10.1134/S1054661819040175.
7. Torshin I.Yu., Rudakov K.V. On metric spaces arising during formalization of recognition and classification problems. Part 1: Properties of compactness. Pattern Recognit Image Anal. 2016; 26 (2): 274–84. https://doi.org/10.1134/S1054661816020255.
8. Torshin I.Yu., Lila A.M., Naumov A.V., et al. Meta-analysis of clinical trials of osteoarthritis treatment effectiveness with Chondroguard. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020; 13 (4): 388–99 (in Russ.). https://doi.org/10.17749/2070-4909/farmakoekonomika.2020.066.
9. Gromova O.A., Torshin I.Yu., Zaychik B.T., et al. Differences in the standardization of medicinal products based on extracts of chondroitin sulfate. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2021; 14 (1): 40–52 (in Russ.). https://doi.org/10.17749/2070-4909/farmakoekonomika.2021.083.
10. Alekseeva L.I., Anikin S.G., Zaytseva E.M., et al. Investigation of the efficacy, tolerability and safety of Chondrogard in patients with osteoarthritis. Russian Medical Journal. 2013; 24 (32): 1624–7 (in Russ.).
11. Clinical guidelines – Gonarthrosis – 2021-2022-2023 (03.09.2021) – Approved by the Ministry of Health of the Russian Federation. Available at: http://disuria.ru/_ld/10/1085_kr21M17MZ.pdf (in Russ.) (accessed 03.10.2021).
12. Clinical guidelines – Coxarthrosis – 2021-2022-2023 (03.09.2021) – Approved by the Ministry of Health of the Russian Federation. Available at: http://disuria.ru/_ld/10/1086_kr21M16MZ.pdf (in Russ.) (accessed 12.10.2021).
Review
For citations:
Torshin I.Yu., Lila А.М., Zagorodniy N.V., Nazarenko А.G., Tkacheva О.N., Dudinskaya Е.N., Alekseeva L.I., Taskina Е.А., Sarvilina I.V., Shavlovskaya О.А., Danilov A.B., Minasov Т.B., Galustyan А.N., Malyavskaya S.I., Gromov А.N., Egorova Е.Yu., Vasilyeva L.V., Evstratova E.F., Gogoleva I.V., Fedotova L.E., Udovika М.I., Maximov V.A., Povzun А.S., Gromova О.А. Development of a verified osteoarthritis risk scale based on a cross-sectional study of clinical and anamnestic parameters and pharmacological anamnesis of patients. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2023;16(1):70–79. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2023.158
Views:
861
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 