Hepatoprotective effects of chondroitin sulfate and glucosamine sulfate
https://doi.org/10.17749/2070-4909/farmakoekonomika.2021.112
Abstract
Background. Long-term use of chondroprotective agents – chondroitin sulfate (CS) and glucosamine sulfate (GS) in the treatment of osteoarthritis puts forward increased requirements for the safety of drugs, primarily in terms of effects on the liver and kidneys.
Objective: systematization of data on the effect of chondroprotectors on liver structure and functions.
Material and methods. Using the methods of the theory of topological text analysis, an intellectual analysis of 2319 publications on fundamental and clinical studies of the relationship of CS and GS with liver function was carried out. The search was performed by a key query “(chondroitine OR glucosamine) AND (liver OR hepatic OR hepatocy*)” in the PubMed/MEDLINE database.
Results. The systematic analysis indicated a pronounced hepatoprotective effect of CS and GS pharmaceutical substances with a high degree of purification from inorganic and organic impurities. By regulating inflammation processes, lymphocyte function, fat and carbohydrate metabolism in the liver, standardized forms of CS and GS have a beneficial effect on fat metabolism, reduce chronic inflammation in the liver, exhibit antitumor and pronounced hepatoprotective effects on various models of liver intoxication.
Conclusion. The results of this analysis allow us to assert the high safety of drugs based on pharmaceutical standardized forms of CS and GS in terms of liver function.
Keywords
hepatoprotection,
efficacy and safety of pharmacotherapy,
chondroitin sulfate,
glucosamine sulfate,
topological data analysis
Supporting agencies: This work was financially supported by the grant of the Russian Science Foundation (No. 20-12-00175) in Ivanovo State University of Chemistry and Technology.
About the Authors
I. Yu. Torshin
Federal Research Center “Informatics and Management”, Russian Academy of Sciences
Russian Federation
Russian Federation
Ivan Yu. Torshin – PhD (Phys. Math.), PhD (Chem.), Senior Researcher
WoS ResearcherID: C-7683-2018
Scopus Author ID: 7003300274
RSCI SPIN-code: 1375-1114
4 Vavilov Str., Moscow 119333
A. M. Lila
Nasonov Research Institute of Rheumatology
Russian Federation
Russian Federation
Aleksandr M. Lila – Dr. Med. Sc., Professor, Director
WoS ResearcherID: W-3334-2017
Scopus Author ID: 6602550827
RSCI SPIN-code: 7287-8555
34А Kashirskoye Hwy, Moscow 115522
O. A. Gromova
Federal Research Center “Informatics and Management”, Russian Academy of Sciences
Russian Federation
Russian Federation
Olga A. Gromova – Dr. Med. Sc., Professor, Research Supervisor
WoS ResearcherID: J-4946-2017
Scopus Author ID: 7003589812
RSCI SPIN-code: 6317-9833
4 Vavilov Str., Moscow 119333
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Torshin I.Yu., Lila A.M., Gromova O.A. Hepatoprotective effects of chondroitin sulfate and glucosamine sulfate. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2021;14(4):537-547. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2021.112
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