Concentration of vitamin D metabolite – 25(OH)D3 as a predictor of breast cancer progression
https://doi.org/10.17749/2070-4909/farmakoekonomika.2022.152
Abstract
Background. Prediction of breast cancer (BC) progression is important for the timely correction of patient therapy.
Objective: to assess a relationship between BC progression and degree of vitamin D deficiency.
Material and methods. A retrospective controlled study was performed. The results of examining 67 women aged 29–48 years with histologically verified BC and vitamin D deficiency are presented. All patients were divided into two groups: the main group – 34 women administered with vitamin D, comparison group – 33 patients not taking vitamin D.
Results. It was shown that 25(OH)D3 level less than 18.9 ng/ml was significantly associated with prominent disease progression, regardless of the tumor molecular subtype. Additional criteria were developed allowing to predict BC progression.
Conclusion. In order to detect secondary changes (distant metastases in ВС patients) and improve patient monitoring, it is recommended to use additional diagnostic methods and determine the intermediate metabolite of vitamin D – 25(OH)D3 in peripheral blood.
About the Authors
D. Е. Frolova
Ivanovo State Medical Academy
Russian Federation
Russian Federation
Daria Е. Frolova – МD, Assistant Professor, Chair of Oncology, Obstetrics and Gynecology
8 Sheremetyevskiy Ave., Ivanovo 153012
N. P. Lapochkina
Ivanovo State Medical Academy
Russian Federation
Russian Federation
Nina P. Lapochkina – Dr. Med. Sc., Professor, Chief of Chair of Oncology, Obstetrics and Gynecology
8 Sheremetyevskiy Ave., Ivanovo 153012
О. А. Gromova
Federal Research Center “Informatics and Management”, Russian Academy of Sciences
Russian Federation
Russian Federation
Olga A. Gromova – Dr. Med. Sc., Professor, Leading Researcher, Research Supervisor, Institute of Pharmacoinformatics
WoS ResearcherID: J-4946-2017
Scopus Author ID: 7003589812
4 Vavilov Str., Moscow 119333
I. Yu. Torshin
Federal Research Center “Informatics and Management”, Russian Academy of Sciences
Russian Federation
Russian Federation
Ivan Yu. Torshin – PhD (Phys. Math.), PhD (Chem.), Senior Researcher, Institute of Pharmacoinformatics
WoS ResearcherID: C-7683-2018
Scopus Author ID: 7003300274
4 Vavilov Str., Moscow 119333
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Review
For citations:
Frolova D.Е., Lapochkina N.P., Gromova О.А., Torshin I.Yu. Concentration of vitamin D metabolite – 25(OH)D3 as a predictor of breast cancer progression. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2022;15(4):472-477. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2022.152
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