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Evaluation of the antitumor drugs therapeutic value using the method of multicriterial analysis of decision-making

https://doi.org/10.17749/2070-4909/farmakoekonomika.2020.056

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Abstract

Aim. Development of a tool for the evaluation of the therapeutic value of anticancer drugs based on multi-criteria analysis of decision making.

Materials and methods. The study included 4 main stages. At the first stage, based on the results of the publications analysis and the EVIDEM system, a list of therapeutic value criteria was formed. At the second stage, for each criterion, a survey of experts was used to develop a scale and to build a value function using the curve-fitting method. At the third stage, the weighing was carried out using the discrete choice experiment method and the statistical package "support.CEs" in R Studio. At the fourth stage, based on the obtained values of the weight coefficients and value functions, a simple linear additive model was constructed.

Results. The authors developed a tool that included 5 criteria for the value of anticancer drugs: efficacy, safety, disease severity, ease of administration, and therapeutic need. For each criterion, a linear value function was built, which allowed the authors to obtain the value of the severity of the criterion in the range from 0 to 1 based on the absolute values of the criterion for a particular drug. As a result of the weighing, two sets of weighting coefficients were obtained by using two different methods of survey results processing. The criterion of efficacy has the most significant contribution to the therapeutic value for the Russian health care system, and the least significant is the severity of the disease. The distribution of the criteria in the intermediate contribution ranks was significantly different between the two sets of weights.

Conclusions. For practical application and implementation of the proposed tool, it is required to conduct the validation using the example of specific antitumor drugs to select a final set of weighting coefficients, check the stability of the results, and form a scale of therapeutic value levels.

About the Authors

V. A. Lemeshko
Centre of Healthcare Quality Assessment and Control, Ministry of Health of the Russian Federation; Financial Research Institute of the Ministry of Finance of Russia; Russian medical Academy of continuous professional Education; Institute of Pharmacy and Translational Medicine, Sechenov University
Russian Federation

10, bldg. 5 Khohlovsky lane, Moscow 109028, Russia; 3-2 Nastasiinsy per., Moscow 127006, Russia; 2/1 bldg.1 ul. Barricadnaya, Moscow 125993, Russia; 8-2 Trubetskaya Str., Moscow 119991, Russia



N. Z. Musina
Centre of Healthcare Quality Assessment and Control, Ministry of Health of the Russian Federation; Russian medical Academy of continuous professional Education; Saint Petersburg State Chemical Pharmaceutical University; Russian Presidential Academy of National Economy and Public Administration
Russian Federation
10, bldg. 5 Khohlovsky lane, Moscow 109028, Russia; 2/1 bldg.1 ul. Barricadnaya, Moscow 125993, Russia; 14 let. A Prof. Popov Str., Saint Petersburg 197376, Russia; 82 Vernadskogo prosp., Moscow 119571, Russia


V. V. Omelyanovskiy
Centre of Healthcare Quality Assessment and Control, Ministry of Health of the Russian Federation; Russian medical Academy of continuous professional Education; Saint Petersburg State Chemical Pharmaceutical University
Russian Federation
10, bldg. 5 Khohlovsky lane, Moscow 109028, Russia; 2/1 bldg.1 ul. Barricadnaya, Moscow 125993, Russia; 14 let. A Prof. Popov Str., Saint Petersburg 197376, Russia


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For citation:


Lemeshko V.A., Musina N.Z., Omelyanovskiy V.V. Evaluation of the antitumor drugs therapeutic value using the method of multicriterial analysis of decision-making. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2020;13(3):262-269. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2020.056

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ISSN 2070-4909 (Print)
ISSN 2070-4933 (Online)