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Efficacy of photodynamic therapy in treatment of adult patients with skin cancer

https://doi.org/10.17749/2070-4909.2019.12.1.42-47

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Abstract

Photodynamic therapy (PDT) is a relatively new non-surgical treatment for cancer and precancerous conditions. The present review focused on studies using PDT in the treatment of basal cell and squamous cell carcinoma and skin melanoma.
The aim was to obtain evidence on the efficacy of PTD in the treatment of skin cancer in patients over 18 years old. To that end, we screened the PubMed database of medical and biological publications and the Cochrane Library without restricting the depth of search.
Materials and methods. We evaluated the data of meta-analyses, results of randomized controlled trials (RCTs), and systematic reviews on RCTs, where the overall survival, survival without relapse, and survival without progression were assessed.
Results. We have found one systematic review of 27 studies of different designs, one meta-analysis of 5 RCTs, and also five RCTs (1165 participants in total), where the efficacy and safety of PDT in patients with basal cell and squamous cell carcinoma were directly compared to surgical treatment, cryotherapy, and chemo-radiation therapy. In another systematic review, PDT used for squamous cell carcinoma was compared with electro-dissection, cryotherapy, curettage, microsurgery and chemo-radiation therapy. According to our search criteria, no comparative studies on the efficacy and safety of PDT in patients with melanoma were found.
Conclusion. The review underscores the efficacy of PDT in patients with both basal cell and squamous cell carcinoma. However, the use of PDT resulted in a lower 5-year survival and a greater recurrence rate compared to the surgical treatment. PDT can be recommended as an alternative to surgery and other treatments for basal cell and squamous cell carcinoma.

About the Author

O. V. Kirsanova
Center for Healthcare Quality Assessment and Control of the Ministry of Health of the Russian Federation
Russian Federation

10-5 Khokhlovskii pereulok, Moscow 109028

Olga V. Kirsanova – MD, General Practitioner, Leading Specialist, Department of Medical Support of Standardization, Center for Healthcare Quality Assessment and Control, Ministry of Healthcare of the Russian Federation.

ResearcherID: M-6492-2015



References

1. Website of the Federal State Statistics Service [Electronic resource] (in Russ.). URL: http://www.gks.ru/wps/wcm/connect/rosstat_main/rosstat/ru/statistics/population/demography/#. Accessed: 15.06.18.

2. Malignant neoplasms in Russia in 2016 (morbidity and mortality). Edited by A. D. Kaprin, V. V. Starinsky, G. V. Petrova (in Russian). Moscow. 2018; 250 s. [Electronic resource] (in Russ.). URL: http://www.oncology.ru/service/statistics/malignant_tumors/2016. pdf. Accessed: 15.06.18.

3. The American Cancer Society. What Are Basal and Squamous Cell Skin Cancers? [Electronic resource] URL: https://www.cancer.org/cancer/basal-and-squamous-cell-skin-cancer/about/what-is-basaland-squamous-cell.html. Accessed: 29.08.2018.

4. Coit D. G., Thompson J. A., Albertini M., Algazi A., Andtbacka R., Bichakjian C., Carson W. E., 3rd, Daniels G. A., DiMaio D., Fields R. C. et al. NCCN Clinical Practice Guidelines in Oncology. Melanoma. Version 1.2017 In.: National Comprehensive Cancer Network, Inc; 2016: 161. [Electronic resource] URL: http://www.mmmp.org/mmmpFile/image/conv%20ther/NCCN%20guidelines_Melanoma.pdf. Accessed: 21.09.2018.

5. Clinical recommendations “Melanoma of the skin” of the Ministry of Health of the Russian Federation (in Russ.). [Electronic resource] URL: http://oncology-association.ru/docs/melanoma_kozhi_2017.pdf. Accessed: 21.09.2018.

6. Clinical recommendations “Basal cell and squamous skin cancer” of the Ministry of Health of the Russian Federation. (in Russ.). [Electronic resource] URL: http://oncology-association.ru/docs/rak-kozhi-bazalnokletochnyj-i-ploskokletochnyj.pdf. Accessed: 21.09.2018.

7. Bichakjian C., Olencki T., Aasi S., Alam M., Andersen J. S., Berg D., Bowen G. M., Cheney R. T., Contreras C. M., Daniels G. A. et al. NCCN Guidelines Version 1.2017 Squamous Cell Skin Cancer. In.: NCCN; 2017: 43. [Electronic resource] URL: http://oncolife.com.ua/doc/nccn/Squamous_Cell_Skin_Cancer.pdf. Accessed: 21.09.2018.

8. Bichakjian C., Olencki T., Aasi S., Alam M., Andersen J. S., Berg D., Bowen G. M., Cheney R. T., Contreras C. M., Daniels G. A. et al: NCCN Guidelines Version 1.2017. Basal Cell Skin Cancer. In.: NCCN; 2016. [Electronic resource] URL: http://www.jnccn.org/content/14/5/574.full.pdf. Accessed: 21.09.2018.

9. Interventions for basal cell carcinoma of the skin: systematic review. BMJ. 2004; 329. AE (Published 23 September 2004). DOI: https://doi.org/10.1136/bmj.38219.515266.

10. Rowe D. E., Carroll R. J., Day C. L., Jr.: Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol. 1992; 26 (6): 976-990.

11. Surgical excision versus Mohs’ micrographic surgery for basal cell carcinoma of the face: A randomised clinical trial with 10 year follow-up. European journal of cancer. Nov 2014; 50 (17): 3011-20.

12. Rkein A.M., Ozog D.M. Photodynamic Therapy. Dermatologic Clinics. 2014; 32, (3): 415-425.

13. Bath-Hextall F.J., Perkins W., Bong J., Williams H.C. Interventions for basal cell carcinoma of the skin. Cochrane Systematic Review – Intervention Version published: 24 January 2007. [Electronic resource] URL: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003412.pub2/full. Accessed: 21.09.2018.

14. Zou Y., Zhao Y., Yu J., Luo X., Han J., Ye Z., Li J. Photodynamic therapy versus surgical excision to basal cell carcinoma: meta-analysis. J Cosmet Dermatol. 2016; 15 (4): 374-382. https://doi.org/10.1111/jocd.12236.

15. Szeimies R.M., Ibbotson S., Murrell D.F., Rubel D., Frambach Y., de Berker D., Dummer R., Kerrouche N., Villemagne H. A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8-20 mm), with a 12-month followup. Excilight Study Group. J Eur Acad Dermatol Venereol. 2008 Nov; 22 (11): 1302-11.

16. Arits A., Mosterd K., Essers B., Spoorenberg E., Sommer A., De Rooij M. et al. Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial. Lancet Oncol. 2013; May 15: 647-654.

17. Roozeboom M. H., Nelemans P. J. Photodynamic therapy vs. topical imiquimod for treatment of superficial basal cell carcinoma: a subgroup analysis within a noninferiority randomized controlled trial. British Journal of Dermatology. 2014; 172 (3): 739-745. DOI: 10.1111/ bjd.13299.

18. Roozeboom M. H., Arits A. Three year follow-up results of photodynamic therapy versus imiquimod versus fluorouracil for treatment of superficial basal cell carcinoma: a single blind, noninferiority, randomized controlled trial. The Journal of Investigative Dermatology. 2016; 136 (8): 1568-1574. DOI: https://doi.org/10.1016/j.jid.2016.03.043.

19. Roozeboom M. H., Aardoom M. A. et al. Fractionated 5-aminolevulinic acid photodynamic therapy after partial debulking versus surgical excision for nodular basal cell carcinoma: A randomized controlled trial with at least 5-year follow-up. J Am Acad Dermatol. 2013; 69 (2): 280-287. DOI: https://doi.org/10.1016/j.jaad.2013.02.014.

20. Bath-Hextall F.J., Matin R. N., Wilkinson D., Leonardi-Bee J. Interventions for cutaneous Bowen’s disease. Send to Cochrane Database Syst Rev. 2013 Jun 24; (6): CD007281. https://doi.org/10.1002/14651858.CD007281.pub2.


For citation:


Kirsanova O.V. Efficacy of photodynamic therapy in treatment of adult patients with skin cancer. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2019;12(1):42-47. (In Russ.) https://doi.org/10.17749/2070-4909.2019.12.1.42-47

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