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METASTATIC COLORECTAL TREATMENT COSTS OF USING TARGETED DRUGS IN SECOND AND FURTHER LINES THERAPY

https://doi.org/10.17749/2070-4909.2016.9.2.038-044

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Abstract

Targeted drugs are recommended for treatment of metastatic colorectal cancer. Second and further lines therapy options include anti-EGFR therapy, eligible for patients with wild-type KRAS (cetuximab and panitumumab), and relatively new drug — regorafenib, which could be used for all patients.

The aim of this study is to compare costs associated with these options in Russia.

Materials and methods. We calculated cost of medication for treating one patient during one month with cetuximab, panitumumab and regorafenib. We also employed cost-effectiveness analysis, but its results should be treated with caution due to non-comparable patients in regorafenib and anti-EGRF drugs studies.

Results. We found that monthly per patient medication costs of using regorafenib are 255,000 rubles, which is 104,000 rubles less when using cetuximab or 184,000 rubles less when using panitumumab. Cost-effectiveness ratio for regorafenib was estimated at 111,500 rubles per month and is the lowest among the alternatives: 136,000 rubles per month for cetuximab and 310,000 rubles per month for panitumumab.

Conclusions. Regorafenib is cost-saving alternative for treatment of metastatic colorectal cancer in second and further lines therapy compared to cetuximab and panitumumab in Russia.

About the Authors

N. A. Avxentyev
Research Institute of Finance, Ministry of Finance of the Russian Federation; Russian Presidential Academy of National Economy and Public Administration
Russian Federation

adviser;

research fellow of Institute of social analysis and forecasting,

Nastasyinsky per., 3-2, Moscow, 127006



E. V. Derkach
Russian Presidential Academy of National Economy and Public Administration; The National Centre for Health Technology Assessment
Russian Federation

PhD (candidate of medical sciences);

leading research fellow of Laboratory for health technology assessment of Applied economic research,

Vernadskogo prospect, 82-1, Moscow, Russia, 119571,

RANEPA IPEI, Laboratory for health technology assessment



E. A. Pyadushkina
Russian Presidential Academy of National Economy and Public Administration; The National Centre for Health Technology Assessment
Russian Federation

research fellow of Laboratory for health technology assessment of Applied economic research Institute;

research fellow,

Vernadskogo prospect, 82-1, Moscow, 119571,

RANEPA IPEI, Laboratory for health technology assessment



M. D. Ter-Ovanesov
Peoples’ Friendship University Of Russia, Moscow
Russian Federation

Head of the Department of Oncology and Haematology Faculty of increase continuing medical education,

Mikluho-Maclay Street, 6, Moscow, 117198



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For citation:


Avxentyev N.A., Derkach E.V., Pyadushkina E.A., Ter-Ovanesov M.D. METASTATIC COLORECTAL TREATMENT COSTS OF USING TARGETED DRUGS IN SECOND AND FURTHER LINES THERAPY. PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology. 2016;9(2):38-44. (In Russ.) https://doi.org/10.17749/2070-4909.2016.9.2.038-044

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ISSN 2070-4909 (Print)
ISSN 2070-4933 (Online)