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COMPARATIVE CLINICAL AND ECONOMIC ANALYSIS OF THE INTENSIFICATION THERAPY IN PATIENTS WITH UNCONTROLLED DIABETES TYPE 2 USING BASAL INSULIN OR DAPAGLIFLOZIN

https://doi.org/10.17749/2070-4909.2016.9.1.058-068

Full Text:

Abstract

Objective. Determine if dapagliflozin use is pharmacoeconomically reasonable option for patients with inadequate glycemic control compared with basal insulin.

Materials and Methods. The study was conducted according to standard pharmacoeconomic methods: cost-utility analysis (CUA), budget impact analysis (BIA).

Results. The use of dapagliflozin as an alternative to basal insulin can reduce health system costs, improves the quality of life of patients, adding 0.73 QALY per patient. Modelling suggests that dapagliflozin introduction could delay the start of insulin treatment by an average of 6.5 years that in turn will allow achieving cost savings and improving the quality of life of patients.

Conclusions. Dapagliflozin therapy is the preferred alternative to basal insulins, due to lower costs and improvement in the quality of life of patients.

About the Authors

V. I. Petrov
Volgograd State Medical University
Russian Federation

MD, professor, academician, Rector,

Head of the Department of Clinical Pharmacology, Head Specialist of the Russian Federation Ministry of Health – Clinical Pharmacology,

Honored Doctor of the Russian Federation,

Square Pavshikh Bortsov, 1, Volgograd, 400131



S. V. Nedogoda
Volgograd State Medical University
Russian Federation

MD, Professor, Head of Therapy and Endocrinology Faculty of Advanced Medical Studies, 

Str. Tsiolkovsky, 1, Volgograd, 400001



M. Yu. Frolov
Volgograd State Medical University
Russian Federation

PhD, associate professor Course HFC Department of Clinical Pharmacology,

Square Pavshikh Bortsov, 1, Volgograd, 400131



A. S. Salasyuk
Volgograd State Medical University
Russian Federation

PhD, assistant chair of therapy and endocrinology Faculty of Advanced Medical, 

Str. Tsiolkovsky, 1, Volgograd, Russia, 400001



I. N. Barykina
Volgograd State Medical University
Russian Federation

PhD, assistant chair of therapy and endocrinology Faculty of Advanced Medical, 

Str. Tsiolkovsky, 1, Volgograd, 400001



V. O. Smirnova
Volgograd State Medical University
Russian Federation

graduate student of chair of therapy and endocrinology Faculty of Advanced Medical, 

Str. Tsiolkovsky, 1, Volgograd, 400001



V. Yu. Khripaeva
Volgograd State Medical University
Russian Federation

graduate student of chair of therapy and endocrinology Faculty of Advanced Medical, 

Str. Tsiolkovsky, 1, Volgograd,  400001.



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For citation:


Petrov V.I., Nedogoda S.V., Frolov M.Y., Salasyuk A.S., Barykina I.N., Smirnova V.O., Khripaeva V.Y. COMPARATIVE CLINICAL AND ECONOMIC ANALYSIS OF THE INTENSIFICATION THERAPY IN PATIENTS WITH UNCONTROLLED DIABETES TYPE 2 USING BASAL INSULIN OR DAPAGLIFLOZIN. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2016;9(1):58-68. (In Russ.) https://doi.org/10.17749/2070-4909.2016.9.1.058-068

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ISSN 2070-4909 (Print)
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