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CLINICAL EFFICIENCY AND THE PHARMACOECONOMIC ANALYSIS OF ALLERGEN IMMUNOTHERAPY AT PATIENTS WITH MILD AND MODERATE ALLERGIC BRONCHIAL ASTHMA

https://doi.org/10.17749/2070-4909.2015.8.2.029-037

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Abstract

Purpose: an assessment of clinical efficiency and carrying out the pharmacoeconomic analysis of allergen immunotherapy at patients with mild and moderate allergic bronchial asthma.

Materials and methods. 108 patients were examined with mild and moderate allergic bronchial asthma, of both sexes who were divided into 4 groups depending on their therapy. The period of observation was 12 months. The 1st group were included 35 patients of mild allergic bronchial asthma receiving allergen immunotherapy in combination with antiinflammatory therapy; the 2nd group were consisted of 22 patients of mild allergic bronchial asthma using only basic therapy; in the 3rd group 17 patients of moderate allergic bronchial asthma receiving allergen immunotherapy in combination with antiinflammatory medicine were observed; the 4th group was made by 34 patients of moderate allergic bronchial asthma receiving only basic therapy. At all patient were investigated the function of external respiration, scarification tests, test АСТтм. For the pharmacoeconomic analysis we used the cost-effectiveness ratio.

Results. Our analysis showed that the scheme of treatment at patients of the 3rd group was economically more profitable in comparison with the scheme of treatment at patients of the 4th group. So at the 3rd group in the end of the period of observation was noted significant improvement of the following indicators: FEV1, decrease of day and night dyspnea attacks, quantity of exacerbations, increase of total point of АСТтм test. Despite the larger value of coefficient of expensive efficiency at patients of the 1st group in comparison with the 2nd group, it is necessary to consider that the allergen immunotherapy interferes the progressing of the disease that will compensate the cost of this method of treatment in the future.

Conclusion. We received the results that showed the efficiency of the timely done allergen immunotherapy at patients with the mild and moderate allergic bronchial asthma, and is able tto reduce financial expenses considerably.

About the Authors

Elena Albertovna Sobko
Krasnoyarsk budgetary state medical university named after prof. V.F. Voino-Yasenetsky, ministry of public health service of the Russian Federation; Regional state budget health agency "Regional Clinical Hospital"
Russian Federation

MD, Assotiated Professor, Department of Internal Diseases N 2;

Head of the Department of Allergy,

Partizana Zheleznyaka str., 1, Krasnoyarsk, 660022



Natalya Vladimirovna Gordeeva
Krasnoyarsk budgetary state medical university named after prof. V.F. Voino-Yasenetsky, ministry of public health service of the Russian Federation
Russian Federation

PhD, Assistant of the Department of Internal Diseases N 2,

Partizana Zheleznyaka str., 1, Krasnoyarsk, 660022



Angelina Yurievna Kraposhina
Krasnoyarsk budgetary state medical university named after prof. V.F. Voino-Yasenetsky, ministry of public health service of the Russian Federation
Russian Federation

PhD, Assistant of the Department of Internal Diseases N 2,

Partizana Zheleznyaka str., 1, Krasnoyarsk, 660022



Irina Anatolyevna Soloveva
Krasnoyarsk budgetary state medical university named after prof. V.F. Voino-Yasenetsky, ministry of public health service of the Russian Federation
Russian Federation

PhD, Assistant, Department of Internal Diseases N 2,

Partizana Zheleznyaka str., 1, Krasnoyarsk, 660022



Svetlana Vladimirovna Chubarova
Krasnoyarsk budgetary state medical university named after prof. V.F. Voino-Yasenetsky, ministry of public health service of the Russian Federation; Regional state budget health agency "Regional Clinical Hospital"
Russian Federation

PhD, Assistant of the Department of Internal Diseases N 2;

Doctor of the Department of Allergy,

Partizana Zheleznyaka str., 1, Krasnoyarsk, 660022



Olga Petrovna Ishenko
Regional state budget health agency "Regional Clinical Hospital"
Russian Federation

PhD, Doctor of the Department of Allergy,

Partizana Zheleznyaka str., 1, Krasnoyarsk, 660022.



Irina Vladimirovna Demko
Krasnoyarsk budgetary state medical university named after prof. V.F. Voino-Yasenetsky, ministry of public health service of the Russian Federation
Russian Federation

M.D., Professor & Head, Department of Internal Diseases N 2,

Partizana Zheleznyaka str., 1, Krasnoyarsk, 660022



Maria Michailovna Loktionova
Krasnoyarsk budgetary state medical university named after prof. V.F. Voino-Yasenetsky, ministry of public health service of the Russian Federation
Russian Federation

student of medical faculty, 

Partizana Zheleznyaka str., 1, Krasnoyarsk, 660022



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For citation:


Sobko E.A., Gordeeva N.V., Kraposhina A.Y., Soloveva I.A., Chubarova S.V., Ishenko O.P., Demko I.V., Loktionova M.M. CLINICAL EFFICIENCY AND THE PHARMACOECONOMIC ANALYSIS OF ALLERGEN IMMUNOTHERAPY AT PATIENTS WITH MILD AND MODERATE ALLERGIC BRONCHIAL ASTHMA. PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology. 2015;8(2):29-37. (In Russ.) https://doi.org/10.17749/2070-4909.2015.8.2.029-037

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ISSN 2070-4909 (Print)
ISSN 2070-4933 (Online)