Objective. To conduct a pharmacoeconomic analysis is required to select an optimal vitamin and mineral complex (VMC) for intensive shortterm courses nutritional support, evaluate the most appropriate CMC both in quality and price. Results: Based on the assessment of pharmacological quality and price data VEC to 127 regions of Russia formulated price categories of drugs and the analysis of available drugs in axes "price-pharmacological quality". Conclusions. A dedicated VMC, the most suitable for intensive short-term courses of vitamin therapy during convalescence, at high loads, etc. 

Introduction. Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as an important and common public health problem that can lead to cirrhosis and hepatic failure (hepatocellular carcinoma – HCC). It may be the most prevalent liver disease. However knowledge of the epidemiology is limited. Most data came from studies conducted in Northern America, Western Europe, Japan and China. A first disease registry in NAFLD (DIREG_L_01903) was performed in 2007 in Russia. This study showed high prevalence of NAFLD within the GP-s patient flow (27%). These findings encourage to conduct a larger sample size study to evaluate the real prevalence of NAFLD in the Russian population and if this prevalence of NAFLD patients has changed in the last 7 years. 

For the purpose of improvement of quality of delivery of health care to women with infertility at Ministry of Health of Chelyabinsk region the Commission on selection and the direction of patients in the medical organizations for carrying out treatment works with use of auxiliary reproductive technologies at the expense of means of regional and federal budgets. In the work the Commission considers indications, contraindications and restrictions to application of extracorporal fertilization, exercises control of sequence of receiving medical care and efficiency of treatment. 

The article presents an analysis of the general legal regulation of medical research in Russian Federation. Issues to be improved are mentioned. The main legal act for management of scientific activities is the Federal Law of 23 August 1996 N 127-FZ "On Science and State Technical Policy". The basic legal norms of the law are outdated and need to be adjusted, and primar items to update are main concepts. Basic definitions of the law need to be clarified and brought into line with international law. In the allocation of budgetary resources and the planning of this activity it is essential to shift the attention from the control over the funds expenditure to the estimation of research results. This will facilitate more effective and transparent spending of budget funds for scientific research in Russian Federation. 

The purpose of the paper is to develop approaches to evaluation of efficiency and effectiveness of R&D organizations with the aim of performancebased funding. Sources and methods. Based on comparative methods, the paper analyzes the Russian and international practice in efficiency and effectiveness evaluation of R&D organizations aimed at stimulating high quality of research and improving the general effectiveness of R&D budgeting in Russia. Results. The authors propose and provide rationale for approaches to identify top R&D organizations based on Research Excellence Index (REI). Methods of evaluation and financing based on the Index are described. Conclusion. Results of application of existing evaluation methods of R&D organizations in Russia cannot be efficiently used in budgetary planning procedures. At the same time, several countries (Great Britain, Australia, New Zealand, et.al.) have accumulated vast experience in evaluation of effectiveness of R&D organizations based on REI. Results of evaluations (combining both qualitative methods and experts’ opinions) are successfully used in distribution of research grants among academic institutions. Application of REI in Russia will allow to provide additional financing to top R&D organizations without necessity to increase the general amount of the national R&D budget. 

The description of the international practice of governmental funding of biomedical research is a significant aspect of development of the methodology for prioritization of funding of science (both basic and applied research) in the Russian Federation. The information about mechanisms of allocation of the governmental budget in biomedical research and about focus themes within biomedical research founded in open information sources is very limited.