FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology

Advanced search

Acute issues in the pharmacotherapy of hand osteoarthritis

Full Text:


The article focuses on the review of a pharmacotherapeutic approach to the therapy of hand osteoarthritis (HO). Apart from non-steroid antiinflammatory drugs (NSAID), promising therapeutic means of HO therapy include steroid drugs, chondroitin sulfate (CS), glucosamine sulfate (GS), and vitamin D. Transdermal application of NSAID and steroid drugs reduces the side effects without a decrease in the effectiveness of the therapy. Reconstructive therapy of cartilaginous and connective tissue of hands includes a long-term application of CS/GS, and in the acute period, injections of CS/GS.

About the Authors

O. A. Gromova
Federal Research Center Computer Sciences and Control, Russian Academy of Sciences; Moscow State University
Russian Federation

Olga A. Gromova - MD, Dr Sci Med, Professor, Senior Researcher, Scientific Director of the Federal Research Center Computer Sciences and Control, RAS; Leading Researcher, Center for Big Data Analysis, MSU; Scopus Author ID: 7003589812; WoS Researcher ID: J-4946-2017; RSCI SPIN-code: 6317-9833; eLIBRARY ID: 94901.

44-2 Vavilova Str., Moscow 119333; 1 Leninskie gory, Moscow 119991

I. Yu. Torshin
Federal Research Center Computer Sciences and Control, Russian Academy of Sciences; Moscow State University
Russian Federation

Ivan Yu. Torshin - MD, PhD, Senior Researcher, Federal Research Center Computer Sciences and Control, RAS; Big Data Storage and Analysis Center, MSU; Scopus Author ID: 7003300274; WoS Researcher ID: C-7683-2018; RSCI SPIN-code: 1375-1114; eLIBRARY ID: 54104.

44-2 Vavilova Str., Moscow 119333; 1 Leninskie gory, Moscow 119991

A. V. Naumov
Russian Gerontological Research and Clinical Center, Pirogov Russian National Research Medical University
Russian Federation

Anton V. Naumov - MD, Dr Sci Med, Professor, Head of the laboratory of diseases of the musculoskeletal system of the Russian gerontological scientific clinical center; RSCI SPIN-code: 4763-9738; eLIBRARY ID: 393279.

1 Ostrovityanova Str., Moscow 117997

L. V. Vasilyeva
Burdenko state medical University
Russian Federation

Lyudmila V. Vasilyeva - MD, Dr Sci Med, Professor, Head of the Department of propaedeutics of internal diseases; RSCI SPIN-code: 7341-8250.

Studencheskaya Str., 10, Voronezh 394036

Ye. F. Yevstratova
Burdenko state medical University
Russian Federation

Yelizaveta F. Yevstratova - MD, Dr Sci Med, Associate Professor, Department of propaedeutics of internal diseases; RSCI SPIN-code 4293-3559; eLIBRARY ID: 647774.

Studencheskaya Str., 10, Voronezh 394036

А. N. Gromov
Federal Research Center Computer Sciences and Control, Russian Academy of Sciences; Moscow State University
Russian Federation

Andrey N. Gromov - research engineer of the Federal Research Center Computer Sciences and Control, RAS; Researcher of the Center for Big Data Analysis, MSU; Scopus Author ID: 7102053964; WoS Researcher ID: C-74762018; RSCI SPIN-code: 8034-7910; eLIBRARY ID: 15082.

44-2 Vavilova Str., Moscow 119333; 1 Leninskie gory, Moscow 119991


1. Van Linthoudt D., Gabay C., So A.K. L’arthrose erosive des. Rev Med Suisse. 2013 Mar 13; 9 (377): 569-70, 572, 574-5.

2. Erickson J.M., Messer T.M. Glucosamine and chondroitin sulfate treatment of hand osteoarthritis. J Hand Surg Am. 2013 Aug; 38 (8): 1638-40.

3. Reginato A.M., Riera H., Vera M., Torres A.R., Espinosa R., Esquivel J.A., Felipe O.J., Bias J.R., Rillo O., Papasidero S., Souto R., Rossi C., Molina J.F., Ballesteros F., Radrigan F., Guibert M., Chico A., Gil M.L., Camacho W., Urioste L., Garcia A.K., Iraheta I., Gutierrez C.E., Duarte M., Castaneda O., Coimbra I., Munoz Louis R., Reveille J., Quintero M. Osteoarthritis in Latin America: Study of Demographic and Clinical Characteristics in 3040 Patients. J Clin Rheumatol. 2015 Dec; 21 (8): 391-7.

4. Kendzerska T., Juni P., King L.K., Croxford R., Stanaitis I., Hawker G.A. The longitudinal relationship between hand, hip and knee osteoarthritis and cardiovascular events: a population-based cohort study. Osteoarthritis Cartilage. 2017 Nov; 25 (11): 1771-1780.

5. Loef M., Damman W., de Mutsert R., Rosendaa F. R., Kloppenburg M. Health-related quality of life in patients with hand osteoarthritis from the general population and the outpatient clinic. The Journal of Rheumatology, jrheum. 2019; 190781.

6. Moe R.H., Grotle M., Kjeken I., Hagen K.B., Kvien T.K., Uhlig T. Disease impact of hand OA compared with hip, knee and generalized disease in specialist rheumatology health care. Rheumatol Oxf Engl. 2013; 52: 189-96.

7. Torshin I.Yu., Gromova O.A., Lila A.M., Limanova O.A. Systematic analysis of the molecular pathophysiology of tenosynovitis: promise for using chondroitin sulfate and glucosamine sulfate. Neurology, Neuropsychiatry, Psychosomatics. 2020; 12 (2): 64-71. (In Russ.)

8. Fung B.W., Tang C.Y., Fung B.K. Does aging matter? The efficacy of carpal tunnel release in the elderly. Arch Plast Surg. 2015 May; 42 (3): 278-81.

9. Liu X., Machado G.C., Eyles J.P., Ravi V, Hunter D.J. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.Br J Sports Med. 2018 Feb; 52 (3): 167-175.

10. Torshin I.Y. Optimal dictionaries of the final information on the basis of the solvability criterion and their applications in bioinformatics. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2013; 23: 319-327.

11. Torshin I.Yu., Rudakov K.V. On the theoretical basis of the metric analysis of poorly formalized problems of recognition and classification. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2015; 25 (4): 577-587.

12. Torshin I.Yu., Gromova O.A. Expert data analysis in molecular pharmacology. 2012; 748 p. (in Russ).

13. Torshin I.Y. The study of the solvability of the genome annotation problem on sets of elementary motifs. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2011; 21 (4): 652-662.

14. Roth S.H., Fuller P. Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older. Clin IntervAging. 2012; 7: 127-37.

15. Rannou F., Pelletier J.P., Martel-Pelletier J. Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb; 45 (4 Suppl): 18-21. semarthrit.2015.11.007.

16. Derry S., Conaghan P., Da Silva J.A., Wiffen P.J., Moore R.A. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev. 2016 Apr 22; 4 (4): CD007400.

17. Dubreuil M., Louie-Gao Q., Peloquin C.E., Choi H.K., Zhang Y., Neogi T. Risk of myocardial infarction with use of selected nonsteroidal anti-inflammatory drugs in patients with spondyloarthritis and osteoarthritis. Ann Rheum Dis. 2018 Aug; 77 (8): 1137-1142.

18. Lee T., Lu N., Felson D.T. Use of non-steroidal anti-inflammatory drugs correlates with the risk of venous thromboembolism in knee osteoarthritis patients: a UK population-based case-control study. Rheumatology. 2016; 55: 1099-105.

19. Martin Arias L.H., Martin Gonzalez A., Sanz Fadrique R., Vazquez E.S. Cardiovascular Risk of Nonsteroidal Anti-inflammatory Drugs and Classical and Selective Cyclooxygenase-2 Inhibitors: A Meta-analysis of Observational Studies. J Clin Pharmacol. 2019 Jan; 59 (1): 55-73.

20. Torshin I.Yu., Gromova O.A., Grishina T.R., Semenov V.A. Chemoreactom profiling of the use of meloxicam, diclofenac, ibuprofen, ketoprofen, nimesulide, dexketoprofen in transdermal forms. Neurology, neuropsychiatry, psychosomatics. 2020; 12 (5): 12-22 (in Russ).

21. Altman R.D. Pharmacological therapies for osteoarthritis of the hand: a review of the evidence. Drugs Aging. 2010 Sep 1; 27 (9): 729-45.

22. Watt F.E. Hand osteoarthritis, menopause and menopausal hormone therapy. Maturitas. 2016 Jan; 83: 13-8.

23. Gromova O.A., Torshin I.Yu., Tetruashvili N.K., Limanova O.A., Serov V.N. Molecular-pharmacological mechanisms of stimulation of hypercoagulation by preparations of oral and transdermal estrogens. Gynecology. 2014; 16 (2): 22-28 (in Russ).

24. Sweetland S., Beral V., Balkwill A., Liu B., Benson V.S., Canonico M., Green J., Reeves G.K. Million Women Study Collaborators. Venous thromboembolism risk in relation to use of different types of postmenopausal hormone therapy in a large prospective study. J Thromb Haemost. 2012 Nov; 10 (11): 2277-86.

25. Jacobsen S., Jensen T.W., Bach-Mortensen P., Hyldstrup L., Sonne-Holm S. Low bone mineral density is associated with reduced hip joint space width in women: results from the Copenhagen Osteoarthritis Study. Menopause. 2007 Nov-Dec; 14 (6): 1025-30.

26. Gromova OA, Torshin I. Yu. Vitamin D. Paradigm change; ed. E. I. Guseva, I. N. Zakharova. Moscow. 2017; 568 p. (in Russ).

27. Gromova O.A., Torshin I.Yu., Spirichev V.B. Genome-wide analysis of vitamin D receptor binding sites indicates a wide range of potential therapeutic uses for vitamin D. Medical advice. 2016; 1: 12-21. (in Russ).

28. Torshin I.Yu., Gromova O.A., Frolova D.E., Grishina T.R., Lapochkina N.P. Dose-dependent chemotranscriptomics analysis of the differential effects of vitamin D3 on gene expression in human neuronal progenitor cells NPC and in MCF7 tumor cells. Pharmacokinetics and Pharmacodynamics. 2018; (2): 35-51. (In Russ.)

29. Limanova O.A., Torshin I.YU., Sardaryan I.S., Kalacheva A.G., Hababpashev A., Karpuchin D., Kudrin A., Yudina N.V., Yegorova Ye.YU., Belinskaya A.YU., Grishina T.R., Gromov A.N., Fedotova L.E., Rudakov K.V., Gromova O.A. Micronutrient provision and women’s health: intellectual analysis of clinicoepidemiological data. Voprosyginekologii, akusherstva iperinatologii. 2014; 13 (2): 5-15. (in Russ).

30. Veronese N., Maggi S., Noale M., De Rui M., Bolzetta F., Zambon S., Corti M.C., Sartori L., Musacchio E., Baggio G., Perissinotto E., Crepaldi G., Manzato E., Sergi G. Serum 25-Hydroxyvitamin D and Osteoarthritis in Older People: The Progetto Veneto Anziani Study. Rejuvenation Res. 2015 Dec; 18 (6): 543-53.

31. Zheng S., Jin X., Cicuttini F., Wang X., Zhu Z., Wluka A., Han W., Winzenberg T., Antony B., Aitken D., Blizzard L., Jones G., Ding C. Maintaining Vitamin D Sufficiency Is Associated with Improved Structural and Symptomatic Outcomes in Knee Osteoarthritis. Am J Med. 2017 Oct; 130 (10): 1211-1218.

32. Yesil H., Sungur U., Akdeniz S., Gurer G., Yalcin B., Dundar U. Association between serum vitamin D levels and neuropathic pain in rheumatoid arthritis patients: A cross-sectional study. Int J Rheum Dis. 2018 Feb; 21 (2): 431-439.

33. Vaishya R., Vijay V., Lama P., Agarwal A. Does vitamin D deficiency influence the incidence and progression of knee osteoarthritis? A literature review. J Clin Orthop Trauma. 2019 Jan-Feb; 10 (1): 9-15.

34. Manoy P., Yuktanandana P., Tanavalee A., Anomasiri W., Ngarmukos S., Tanpowpong T., Honsawek S. Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients. Nutrients. 2017 Jul 26; 9 (8).

35. Gao X.R., Chen Y.S., Deng W. The effect of vitamin D supplementation on knee osteoarthritis: A meta-analysis of randomized controlled trials. Int J Surg. 2017 Oct; 46: 14-20.

36. Lila A.M., Torshin I.Yu., Gromova O.A. Is it worthwhile rethinking the positive experience of the last 50 years of using chondroitin sulfates against atherosclerosis? Farmakoekonomika. Sovremennaya farmakoekonomika i farmakoepidemiologiya / Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(2):184-191. (In Russ.)

37. Gromova O.A., Torshin I.Yu., Lila A.M., Gromov A.N. Molecular mechanisms of action of glucosamine sulfate in the treatment of degenerative-dystrophic diseases of the joints and spine: results of proteomic analysis. Neurology, Neuropsychiatry, Psychosomatics. 2018; 10 (2): 38-44. (In Russ.)

38. Torshin I.Yu., Gromova O.A., Lila A.M., Naumov A.V., Sorokina M.A., Rudakov K.V. The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities. Modern Rheumatology Journal. 2018;12(4):129-136. (In Russ.)

39. Zhang W., Doherty M., Leeb B.F. et al. EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2007; 66 (3): 377-388.

40. Kolasinski S.L., Neogi T., Hochberg M.C., Oatis C., Guyatt G., Block J., Callahan L., Copenhaver C., Dodge C., Felson D., Gellar K., Harvey W.F., Hawker G., Herzig E., Kwoh C.K., Nelson A.E., Samuels J., Scanzello C., White D., Wise B., Altman R.D., DiRenzo D., Fontanarosa J., Giradi G., Ishimori M., Misra D., Shah A.A., Shmagel A.K., Thoma L.M., Turgunbaev M., Turner A.S., Reston J. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Rheumatol. 2020; 72: 220-233.

41. Verbruggen G., Goemaere S., Veys E.M. Systems to assess the progression of finger joint osteoarthritis and the effects of disease modifying osteoarthritis drugs. Clin Rheumatol. 2002 Jun; 21 (3): 231-3.

42. Scarpellini M., Lurati A., Vignati G., Marrazza M.G., Telese F., Re K., Bellistri A. Biomarkers, type II collagen, glucosamine and chondroitin sulfate in osteoarthritis follow-up: the “Magenta osteoarthritis study”. J Orthop Traumatol. 2008 Jun; 9 (2): 81-7.

43. Gabay C., Medinger-Sadowski C., Gascon D., Kolo F., Finckh A. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis Rheum. 2011 Nov; 63 (11): 3383-91.

44. Tenti S., Giordano N., Mondanelli N., Giannotti S., Maheu E., Fioravanti A. A retrospective observational study of glucosamine sulfate in addition to conventional therapy in hand osteoarthritis patients compared to conventional treatment alone. Aging Clin Exp Res. 2020; 32 (6): 1161-1172.

45. Rovetta G., Monteforte P., Molfetta G., Balestra V. Chondroitin sulfate in erosive osteoarthritis of the hands.Int J Tissue React. 2002; 24 (1): 29-32.

46. Gromova O.A., Torshin I.Yu., Lila A.M., Naumov A.V., Reier I.A., Karateev A.E. Differential chemoreactome analysis of glucosamine sulfate and non-steroidal anti-inflammatory drugs: promising synergistic drug combinations. Modern Rheumatology Journal. 2018; 12 (2): 36-43. (In Russ.)

47. Vasilyeva L.V., Evstratova E.F., Suslova E.Yu. The use of injectable chondroitin sulfate in combination with dosed physical exercise for the treatment of patients with hand osteoarthritis. Modern Rheumatology Journal. 2020;14(3):79-83. (In Russ.)

48. Vasilyeva L.V., Evstratova E.F., Nikitin A.V., et al. Step-by-step therapy with chondroitin sulfate in patients with osteoarthritis in an outpatient setting. Modern Rheumatology Journal. 2017; 11 (3): 77-80 (In Russ.).

49. Naumov A.V., Sharov M.N., Khovasova N.O., Prokofieva Yu.S. The results of the use of the intermittent scheme of parenteral administration of chondroitin sulfate and glucosamine sulfate in the initial therapy of chronic pain in the joints and back in comorbid patients. RMZH 2018; 4 (II): 47-54 (In Russ.).

50. Takeuchi S., Nakano S.-I., Nakamura K., Ozoe A., Chien P., Yoshihara H., Nishihara M. Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues. Experimental Cell Research. 2016; 347 (2): 367-377.


For citations:

Gromova O.A., Torshin I.Yu., Naumov A.V., Vasilyeva L.V., Yevstratova Y.F., Gromov А.N. Acute issues in the pharmacotherapy of hand osteoarthritis. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(4):452-462. (In Russ.)

Views: 472

ISSN 2070-4909 (Print)
ISSN 2070-4933 (Online)