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Meta-analysis of clinical trials of osteoarthritis treatment effectiveness with Chondroguard

https://doi.org/10.17749/2070-4909/farmakoekonomika.2020.066

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Abstract

Aim. A meta-analysis of 8 controlled studies (n=771, age 53.6±6.2 years) of tie use of tie Chondroguard (100 mg i.m. first 3 injections, from tie 4th injection - 200 mg i.m., EOD, course 20-30 injections) in the complex therapy of osteoarthritis (OA).

Materials and Methods. Tie meta-analysis according to tie fixed-effects model included all published clinical studies on tie efficacy and safety of the CG drug in OA). The effectiveness of therapy was assessed using the VAS, Lequesne, WOMAC scales/indices. For each study, information was collected on 23 features. Data analysis was carried out using the MEDSTUDY and "R" software packages.

Results. Meta-analysis confirmed significant associations between the use of Chondroguard (CG. and pain reduction assessed by the visual analog scale (V)S. - CG: a decrease in pain intensity by -28.3 points, control: -11.6; p=0.042. There was a significant reduction in pain according to VAS at night (CG: -20.1; control: -9.9; p=0.05018., while sitting or lying down (CG: -15.5; control: -7.6; p=0.01656., when walking (CG: -28.2; control: -17.0; p=0.04957). The use of CG led to a significant decrease in the scores of the Lequesne index (CG: -4.3; control: -1.4; p=0.0349., and of the WOMAC index (CG: -338.4; control: -219.8; p=0.004., including WOMAC "function" (CG: -247.8; control: -96; p=0.0027., and WOMAC "stiffness" (CG: -25.4; control: -11.2; p=0.0462.. The incidence of side effects did not differ significantly from the control.

Conclusion. Chondroguard is an effective treatment for osteoarthritis and has a good safety profile.

About the Authors

I. Yu. Torshin
Federal Research Center Computer Sciences and Control, Russian Academy of Sciences; Moscow State University
Russian Federation

Ivan Yu. Torshin - MD, PhD, Senior Researcher, Federal Research Center Computer Sciences and Control, Russian Academy of Sciences, Russian Academy of Sciences; Big Data Storage and Analysis Center, MSU; Scopus Author ID: 7003300274; WoS Researcher ID: C-76832018; RSCI SPIN-code: 1375-1114; eLIBRARY ID: 54104.

44-2 Vavilova Str., Moscow 119333; 1 Leninskie gory, Moscow 119991



A. M. Lila
V.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation
Russian Federation

Aleksandr M. Lila - MD, Dr Sci Med, Professor, Director, V.A. Nasonova Research Institute of Rheumatology, Head of the Department of Rheumatology, RMA Continuous Professional Education of the Ministry of Health RF; Scopus Autor ID: 6602550827; WoS Researcher ID: W-3334-2017-7287-8555; eLIBRARY ID: 367966.

34A Kashirskoye Shosse, Moscow 115522; 2/1, bld.1 Barrikadnaya Str., Moscow 125993



A. V. Naumov
Pirogov Russian National Research Medical University
Russian Federation

Anton V. Naumov - MD, Dr Sci Med, Professor, Head of the Laboratory of Diseases of the Musculoskeletal System of the Russian Gerontological Scientific Clinical Center, Pirogov RNRMU; RSCI SPIN-code: 4763-9738; eLIBRARY ID: 393279.

1 Ostrovityanova Str., Moscow 117997



A. Yu. Kochish
National Medical Research Center of Traumatology and Orthopaedics named by R.R.Vreden
Russian Federation

Aleksandr Yu. Kochish - MD, Dr Sci Med, Professor, Deputy Director for Science and Education; Scopus Author ID: 57190619817; WoS Researcher ID: B-5731-2016; RSCI SPIN-code: 7522-8250; eLIBRARY ID: 354720.

8 Academician Baykova Str., St. Petersburg 195427



L. I. Alekseeva
V.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation
Russian Federation

Lyudmila I. Alekseyeva - MD, Dr Sci Med, Professor, Head of the Department of Metabolic Diseases of Bones and Joints with of Century of Osteoporosis, V.A. Nasonova Research Institute of Rheumatology; Professor of the Department of Rheumatology, RMA of Continuous Professional Education MH RF; Scopus Author ID: 7102418818; WoS Researcher ID: 1-7028-2017; RSCI SPIN-code: 4714-8572.

34A Kashirskoye Shosse, Moscow 115522; 2/1, bld.1 Barrikadnaya Str., Moscow 125993



E. A. Taskina
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Elena A. Taskina - MD, PhD, Senior Scientific Researcher of the Department of Metabolic Diseases of Bones and Joints with of Century of Osteoporosis, V.A. Nasonova RIR; Professor of the Department of Rheumatology, Russian Medical Academy of Continuous Professional Education MH RF; Scopus Author ID: 5579984900; WoS Researcher ID: ABG-2856-2020; RSCI SPIN-code: 8866-7146.

34A Kashirskoye Shosse, Moscow 115522



I. V. Sarvilina
Medical Center Novomeditsina, LLC
Russian Federation

Irina V. Sarvilina - MD, PhD, Clinical Pharmacologist, Chief Physician, LLC Medical Center Novomeditsina; RSCI SPIN-code: 7308-6756.

74 Sotsialisticheskaya Str., Rostov-on-Don 344002



A. N. Galustyan
St. Petersburg State Pediatric Medical University
Russian Federation

Anna N. Galustyan - MD, PhD, Associate Professor, Head of the Department of Pharmacology, St.PSPMU; Scopus Author ID: 6701491872; WOS Research ID: B-6288-2016; RSCI SPIN-code: 7190-2147; eLIBRARY ID: 19199.

2 Litovskaya Str., St. Petersburg 194100



A. N. Gromov
Federal Research Center Computer Sciences and Control, Russian Academy of Sciences; Moscow State University
Russian Federation

Andrey N. Gromov - research engineer of the Federal Research Center Computer Sciences and Control, RAS; Researcher of the Center for Big Data Analysis, MSU; Scopus Author ID: 7102053964; WoS Researcher ID: C-7476-2018; RSCI SPIN-code: 8034-7910; eLIBRARY ID: 15082.

44-2 Vavilova Str., Moscow 119333; 1 Leninskie gory, Moscow 119991



A. K. Khadzhidis
St. Petersburg State Pediatric Medical University
Russian Federation

Alexandr K. Hadzhidis - MD, PhD, Associate Professor, Department of Pharmacology.

2 Litovskaya Str., St. Petersburg 194100



L. V. Vasilieva
State budgetary educational institution of higher professional education "Voronezh State Medical University named after N.N. Burdenko
Russian Federation

Lyudmila V. Vasilyeva - MD, Dr Sci Med, Professor, Head of the Department of Propaedeutics of Internal Diseases of VSMU Burdenko SMU.

Studencheskaya Str., 10, Voronezh 394036



E. F. Yevstratova
State budgetary educational institution of higher professional education "Voronezh State Medical University named after N.N. Burdenko
Russian Federation

Yelizaveta F. Yevstratova - MD, Dr Sci Med, Associate Professor, Department of Propaedeutics of Internal Diseases of VSMU, Burdenko SMU.

Studencheskaya Str., 10, Voronezh 394036



M. I. Udovika
Federal state institution of public health services Medical-sanitary part of the Ministry of Internal Affairs of the Russian Federation the Ulyanovsk region
Russian Federation

Maya I. Udovika - Rheumatologist of the Highest Category, Federal State Institution of Public Health Services Medical-Sanitary Part of the Ministry of Internal Affairs of the RF Ulyanovsk Region.

17 Orlova Str., Ulyanovsk 432071



O. A. Gromova
Federal Research Center Computer Sciences and Control, Russian Academy of Sciences; Moscow State University
Russian Federation

Olga A. Gromova - MD, Dr Sci Med, Professor, Senior Researcher, Scientific Director of the Federal Research Center Computer Sciences and Control, RAS; Leading Researcher, Center for Big Data Analysis, MSU; Scopus Author ID: 7003589812; WoS ResearcherID: J-4946-2017; RSCI SPIN-code: 6317-9833; eLIBRARY ID: 94901

44-2 Vavilova Str., Moscow 119333; 1 Leninskie gory, Moscow 119991



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For citation:


Torshin I.Yu., Lila A.M., Naumov A.V., Kochish A.Yu., Alekseeva L.I., Taskina E.A., Sarvilina I.V., Galustyan A.N., Gromov A.N., Khadzhidis A.K., Vasilieva L.V., Yevstratova E.F., Udovika M.I., Gromova O.A. Meta-analysis of clinical trials of osteoarthritis treatment effectiveness with Chondroguard. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(4):388-399. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2020.066

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