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Pharmacoeconomic analysis of tiotropium bromide and olodaterol fixed combination as maintenance therapy for patients with COPD in the Russian Federation

https://doi.org/10.17749/2070-4909/farmakoekonomika.2020.045

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Abstract

Aim. To assess the economic efficacy of a fixed combination tiotropium bromide+olodaterol (T+O) in comparison with other medications, included in the Vital and Essential Drugs List (VEDL), for the maintenance triple therapy of chronic obstructive pulmonary disease (COPD).

Materials and Methods. A Markov model was used for the estimation of direct medical costs associated with different medications. Costminimization and budget impact analyses were performed.

Results. The drug costs for T+O were the lowest among all compared treatment strategies. The cost savings in favor of T+O were 24.82% [15.86–29.95%]. The application of T+O strategy in 4,101 target patients led to a decrease in the total direct medical costs under the state programs of guarantees of free medical care by 13.13% in 3 years, which will make T+O therapy available to 643 more patients in the first year and 1,624 patients in three years.

Conclusion. A fixed combination T+O is a preferred efficient option for maintenance triple treatment for patients with COPD in comparison with other drugs from VEDL, because it is associated with lower total costs and equal efficacy.

About the Authors

S. V. Nedogoda
Volgograd State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

MD, Dr Sci Med, professor, Head of the Department of Internal Diseases

RSCI SPIN-code: 7005-7846



M. Yu. Frolov
Volgograd State Medical University of the Ministry of Health of the Russian Federation; Volgograd medical scientific center
Russian Federation

MD, PhD, Associate Professor, Department of Pharmacology and Pharmacy; Head Department of
Pharmacology

Researcher ID: F-8355-2015;

Scopus Author ID: 35193977700. RSCI SPIN-code: 7585-1728

1 pl. Pavshikh Bortsov, Volgograd 400131, Russia



A. S. Salasyuk
Volgograd State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

MD, PhD, Associate Professor, Department of Internal Medicine

RSCI SPIN-code: 2651-2916

1 pl. Pavshikh Bortsov, Volgograd 400131, Russia



I. N. Barykina
Volgograd State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

MD, PhD, Associate Professor, Department of Internal Medicine;

RSCI SPIN-code: 5894-7499

1 pl. Pavshikh Bortsov, Volgograd 400131, Russia



V. O. Smirnova
Volgograd State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

MD, PhD, Assistant, Department of Internal Medicine

RSCI SPIN-code: 4601-9910

1 pl. Pavshikh Bortsov, Volgograd 400131, Russia



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For citation:


Nedogoda S.V., Frolov M.Yu., Salasyuk A.S., Barykina I.N., Smirnova V.O. Pharmacoeconomic analysis of tiotropium bromide and olodaterol fixed combination as maintenance therapy for patients with COPD in the Russian Federation. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2020;13(2):101-111. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2020.045

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