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PHARMACOECONOMIC STUDY OF OLMESARTAN/LERCANIDIPINE AND OFENOPRIL/LERCANIDIPINE COMBINATIONS IN THE TREATMENT OF PATIENTS WITH ESSENTIAL HYPERTENSION

https://doi.org/10.17749/2070-4909.2016.9.4.003-008

Full Text:

Abstract

Objective. Pharmacoeconomic analysis of the use of combinations of antihypertensive drugs were olmesartan/lercanidipine and zofenopril/lercanidipine in patients with essential hypertension II-III stage.

Materials and methods. The authors performed prospective randomized uncontrolled study. Were examined in 27 people essential hypertension with II-III stage age from 40 to 71 years before and after the use of combinations of drugs olmesartan/lercanidipine and zofenopril/lercanidipine. An ABC/VEN-analysis, сost-effectiveness analysis, comparative assessment of the incidence of side effects of the studied drugs were performed.

Results. Anti-hypertensive effect of the studied combinations of drugs were not significantly different and equally effectively reduced blood pressure. But the cost of blood pressure reduction at 1 mm Hg was the smallest in the group zofenopril/lercanidipine.

Conclusion. The results of pharmacoeconomic analysis to be more cost-effective combination for the treatment of patients with essential hypertension II-III stage is the combination of zofenopril/lercanidipine.

About the Authors

D. S. Kaskaeva
Krasnoyarsk State Medical University named after Professor V. F. Voino-Yasenetsky
Russian Federation

PhD, head of the Department of General practice, associate Professor in the Department of outpatient therapy, family medicine and healthy lifestyle with a course of postgraduate education State budgetary educational institution of higher professional education “Krasnoyarsk state medical University named after Professor V. F. Voyno-Yasenetsky”. Address: ul. Partizana Zheleznyaka, 1, Krasnoyarsk, Russia, 660022



M. M. Petrova
Krasnoyarsk State Medical University named after Professor V. F. Voino-Yasenetsky
Russian Federation

MD, Vice-rector on scientific work, head of the Department of polyclinic therapy and family medicine and healthy lifestyle with a course of postgraduate education State budgetary educational institution of higher professional education “Krasnoyarsk state medical University named after Professor V. F. Voyno-Yasenetsky”. Address: ul. Partizana Zheleznyaka, 1, Krasnoyarsk, Russia, 660022



O. V. Zimnitskaya
Krasnoyarsk State Medical University named after Professor V. F. Voino-Yasenetsky Regional state budgetary healthcare institution Regional clinical hospital
Russian Federation

postgraduate student of the Department of polyclinic therapy and family medicine and healthy lifestyle with a course of postgrad-uate education State budgetary educational institution of higher professional education “Krasnoyarsk state medical University named after Professor V. F. Voyno-Yasenetsky”; cardiologist Consultative-diagnostic clinic Regional clinical hospital 



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For citation:


Kaskaeva D.S., Petrova M.M., Zimnitskaya O.V. PHARMACOECONOMIC STUDY OF OLMESARTAN/LERCANIDIPINE AND OFENOPRIL/LERCANIDIPINE COMBINATIONS IN THE TREATMENT OF PATIENTS WITH ESSENTIAL HYPERTENSION. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2016;9(4):3-8. (In Russ.) https://doi.org/10.17749/2070-4909.2016.9.4.003-008

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