HEALTH ECONOMIC ASSESSMENT OF ANTIRHEUMATIC DRUGS IN PATIENTS WITH REUMATHOID ARTHRITIS PROGRESSED AFTER METOTREXATE
Abstract
Objective. To perform health economic evaluation of several antirheumatic drugs in patients with rheumatoid arthritis (RA) progressed after DMARDs.
Materials and methods. Three consequent line of rheumatoid arthritis therapy in patients progressed after methotrexate were modeled in Russian economic conditions. Markov modelling and CEA accounting for direct medical costs were used. The effectiveness criteria of RA treatment were: patient-years in remission and patient-years in low disease activity. We compared 12 different treatment regimens of second, third and fourth therapy line in patients progressed after methotrexate.
Results. The health economic analysis of different RA treatment regimen after progression on methotrexate showed that evaluated regimens do not differs in terms of effectiveness and safety. At the mean time the model account for the patients compliance and showed that the maximum number of patient-years in remission can be reached with etanercept and tofacitinib treatment. Moreover, above mentioned combination in comparison to adalimumab and infliximab showed the positive budget impact.
Conclusion. The choice of etanercept and tofacitinib in case of similar economics should be done accounting for individual patient features.
About the Authors
A. S. Kolbin
The first St. Petersburg State Medical University named after Academician Pavlov
Saint Petersburg State University
Russian Federation
Russian Federation
MD, professor, head of department of clinical pharmacology and evidence-based medicine, First St. Petersburg State Medical University. address: ul. L’va Tolstogo, 6-8, St. Petersburg, Russia, 197022; Professor of the Department of Farmakology of St. Petersburg State University. address: 21-Line, 8, VO, St. Petersburg, Russia, 199106. Tel.: +7(812)3386685
A. A. Kurylev
The first St. Petersburg State Medical University named after Academician Pavlov
Russian Federation
Russian Federation
assistant of the Department of clinical pharmacology and evidence-based medicine, The first St. Petersburg State Medical University named after Academician Pavlov. Address: ul. Lva Tolstogo, 6-8, St. Petersburg, Russia, 197022
M. A. Proskurin
Saint Petersburg State University
Russian Federation
Russian Federation
researcher, Saint-Petersburg State University. address: Universitetskii pr., 35, Saint-Petersburg, Russia, 198504. Tel.: +7(812)4287159
Yu. E. Balykina
Saint Petersburg State University
Russian Federation
PhD, senior lecturer, Saint-Petersburg State University, Saint-Petersburg. address: 198504, Universitetskii pr., 35. Tel.: +7(812)4287159
Russian Federation
PhD, senior lecturer, Saint-Petersburg State University, Saint-Petersburg. address: 198504, Universitetskii pr., 35. Tel.: +7(812)4287159
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For citation:
Kolbin A.S., Kurylev A.A., Proskurin M.A., Balykina Y.E. HEALTH ECONOMIC ASSESSMENT OF ANTIRHEUMATIC DRUGS IN PATIENTS WITH REUMATHOID ARTHRITIS PROGRESSED AFTER METOTREXATE. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2016;9(3):20-28. (In Russ.) https://doi.org/10.17749/2070-4909.2016.9.3.020-028
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