DRUGS PROVIDED TO BREAST CANCER PATIENTS WITHIN THE STATE PROGRAMS OF DRUG SUPPLY
Abstract
The purpose of our research was to analyze the actual practice of medicine in patients with breast cancer in various regions of the Russian Federation in the framework of state programs of drug provision (procurement of essential drugs (EDPP) and of regional benefits (RBP)).
Materials and Methods. We collected data on dispensed medicines from 42 regions of the Russian Federation, which accounted for 57.58% of the total population and 58.20% of the total number of breast cancer patients who had been registered in the oncological institutions of the Russian Federation in 2013. We collected and studied data on the antineoplastic agents (L01) and hormonal antineoplastic drugs (L02) dispensed through programs of drug supply from federal and regional budgets in 2013 in the regions of the Russian Federation for patients with a diagnosis of «malignant neoplasm of the breast» (C50 International Classification of Diseases, 10th revision).
Results. The number of drugs prescribed to patients with breast cancer in studied regions ranged from 3 to 39 INNs. Among the most commonly used antineoplastic agents were trastuzumab and capecitabine (both used in 92.86% of the regions), and among hormonal antineoplastic drugs were aromatase inhibitors and tamoxifen (95.24% and 100% of the regions of the Russian Federation). Consumption of drugs varied significantly between the
regions.
Conclusion. Our study revealed significant differences in the consumption of antineoplastic medications among outpatients with breast cancer in different regions of the Russian Federation whose care was funded by federal and regional budgets.
About the Authors
M. V. Avxentyeva
Russian Presidential Academy of National Economy and Public Administration, Moscow
FSBEI HE I.M. Sechenov First MSMU MOH Russia
Russian Federation
Russian Federation
PhD (doctor of medical sciences), leading research fellow of the Centre for health technology assessment of Applied economic research Institute of the Russian Presidential Academy of National Economy and Public Administration, leading research fellow of Centre for health finance of Research Financial institution of Ministry of Finance and Professor of High school of healthcare administration of the Sechenov First Moscow state medical university. Address: Vernadskogo prospect, 82-1, Moscow, Russia, 119571, RANEPA, Centre for health technology assessment. Tel.: +74999569528, +74999569529
V. I. Bogin
Stand Up to Cancer, Los Angeles, CA, USA
Russian Federation
MD, FACP, Founder and Chief Executive Officer of Cromos Pharma, Address: 3042 Monte Vista Terrace, Portland, OR, 97210
Russian Federation
MD, FACP, Founder and Chief Executive Officer of Cromos Pharma, Address: 3042 Monte Vista Terrace, Portland, OR, 97210
E. V. Derkach
Russian Presidential Academy of National Economy and Public Administration, Moscow
The National Centre for Technology Assessment in Health Care, Moscow
Russian Federation
Russian Federation
PhD (candidate of medical sciences), leading research fellow of Laboratory for health technology assessment of Applied economic research Institute of Russian academy of national economy and public administration. Address: Vernadskogo prospect, 82-1, Moscow, Russia, 119571, RANEPA IPEI, Laboratory for health technology assessment. Tel.: +7(499)9569528; +7(499)9569529
V. V. Omelyanovskiy
Russian Presidential Academy of National Economy and Public Administration, Moscow
Russian Federation
Russian Federation
MD, Professor, Director of the Center for Technology Assessment in Health Care of the Institute of Applied Economic Research of RANEPA, Head of the Health Care Finance Center of the Research Financial Institute of the Ministry of Finance of the Russian Federation. Address: Nastas’inskii pereulok, 3-2, Moscow, Russia, 127006. Tel.: +7(499)9569528
M. B. Stenina
Federal State Budgetary Institution «N.N. Blokhin Russian Cancer Research Center», Moscow
Russian Federation
Russian Federation
PhD (doctor of medical sciences), leading research fellow of the Department of Clinical Pharmacology and Chemotherapy of the Federal State Budgetary Institution «N.N. Blokhin Russian Cancer Research Center». Address: Kashirskoe shosse, 24, Moscow, Russia, 115478. Tel.: +7(499)3242660
A. V. Tarakanov
Сromos Pharma, Moscow
Russian Federation
MD, Managing Director of Cromos Pharma, LLC. Address: ul. Kravchenko, 18-58, Moscow, Russia, 119331
Russian Federation
MD, Managing Director of Cromos Pharma, LLC. Address: ul. Kravchenko, 18-58, Moscow, Russia, 119331
M. Yu. Frolov
Volgograd State Medical University of Public Health Ministry of the Russian Federation
Russian Federation
Russian Federation
PHD (candidate of medical sciences), associate professor (Course of Postgraduate Education) of Clinical Pharmacology and Intensive Care Department of Volgograd State Medical University. Address: Pavshih borzov pl., 1, Volgograd, Russia, 400131. Tel.: +7 (902) 383-10-20
References
1. Discrimination based on a geographic basis. Equal Right to Life [Diskriminatsiya po geograficheskomu priznaku. Ravnoe pravo na zhizn’. №14, 25.03.2014 (in Russian)]. URL: http://www.ravnoepravo.ru/fileadmin/templates/journal/gazeta_RPNJ_14.pdf. Accessed: 06.03.15.
2. Malignancies in Russia in 2013 (morbidity and mortality) [Report on the implementation of the Programme of state guarantees to citizens of the Russian Federation free medical care in 2013 [Doklad o realizatsii Programmy gosudarstvennykh garantii okazaniya grazhdanam Rossiiskoi Federatsii besplatnoi meditsinskoi pomoshchi v 2013 g. (in Russian)] URL: http://www.rosminzdrav.ru/documents/8122-doklad-o-realizatsii-programmy- gosudarstvennyhgarantiy-besplatnogo-okazaniya-grazhdanam-meditsinskoypomoschi-v-2013-godu. Accessed: 06.03.15.
3. Malignancies in Russia in 2013 (morbidity and mortality) [Zlokachestvennye novoobrazovaniya v Rossii v 2013 godu (zabolevaemost’ i smertnost’) (in Russian)]. Moscow. 2015. 250 s.
4. Report on the results of the monitoring of drug supply system of the Russian Federation population. 10/29/2014 Russian Public Council of the Ministry of Health [Otchet o rezul’tatakh monitoringa sistemy lekarstvennogo obespecheniya naseleniya Rossiiskoi Federatsii. Obshchestvennyi Sovet Ministerstva zdravookhraneniya RF 29.10.2014(in Russian)]. URL: http://static-0.rosminzdrav.ru/system/attachments/attaches/000/023/549/original/%D0%9F%D1%80%D0%BE %D1%82%D0%BE%D0%BA%D0%BE%D0%BB_%E2%84%969_%D0%9F%D1%80%D0%B8%D0%BB%D0%BE%D0%B6%D0%B5 %D0%BD%D0%B8%D0%B53%D0%B0.pdf?1422611178. Accessed: 05.02.15.
5. Russian Federation Government Resolution dated July 30, 1994 № 890 «On state support of development of the medical industry and improving the provision of population and public health institutions with medicines and medical devices.» [Postanovlenie Pravitel’stva Rossiiskoi Federatsii ot 30 iyulya 1994 g. № 890 «O gosudarstvennoi podderzhke razvitiya meditsinskoi promyshlennosti i uluchshenii obespecheniya naseleniya i uchrezhdenii zdravookhraneniya lekarstvennymi sredstvami i izdeliyami meditsinskogo naznacheniya» (in Russian)]. URL: http://www.consultant.ru/document/cons_doc_LAW_4208/ca1820d99f2c758e82d835816b28c0a3 4417dc33/.Accessed: 07.04.2015 g.
6. Order of the Health Ministry of the Russian Federation of 18.09.2006 (ed. By 10.11.2011) N 665 «On approval of the list of drugs, including a list of medications prescribed by a decision of the medical commission of medical institutions, to ensure that is carried out in accordance with standards medical care by a physician prescription (medical assistant) in the provision of state social assistance in the form of social services» [Prikaz Minzdravsotsrazvitiya RF ot 18.09.2006 (red. ot 10.11.2011) N 665 «Ob utverzhdenii Perechnya lekarstvennykh preparatov, v tom chisle perechnya lekarstvennykh preparatov, naznachaemykh po resheniyu vrachebnoi komissii lechebno-profilakticheskikh uchrezhdenii, obespechenie kotorymi osushchestvlyaetsya v sootvetstvii so standartami meditsinskoi pomoshchi po retseptam vracha (fel’dshera) pri okazanii gosudarstvennoi sotsial’noi pomoshchi v vide nabora sotsial’nykh uslug» (in Russian)]. URL: http://www.consultant.ru/document/cons_doc_LAW_122225/?frame=1. Accessed: 07.04.2015 g.
7. Condition of cancer care the population of Russia in 2013 [Decree of the RF Government dated 12.07.2011, N 2199-r «On approval of the list of vital and essential drugs for 2012» [Rasporyazhenie Pravitel’stva RF ot 7.12.2011 g. N 2199-r «Ob utverzhdenii perechnya zhiznenno neobkhodimykh i vazhneishikh lekarstvennykh preparatov na 2012 god» (in Russian)]. URL: http://base.consultant.ru/cons/cgi/online.cgi?req=doc;base=LAW;n=123291;div=LAW;dst=0,0;rnd=0.16236886149272323. Accessed: 06.03.15.
8. Condition of cancer care the population of Russia in 2013 [Sostoyanie onkologicheskoi pomoshchi naseleniyu Rossii v 2013 godu (in Russian)]. Moscow. 2014; 235 s.
9. Rossiiskaya gazeta. 24.05.2013; Spetsvypusk 110/1. URL: http://base.consultant.ru/cons/cgi/online.cgi?req=doc;base=LAW;n=140820;div=LAW;dst=0,0;rnd=0.9444209749344736. Accessed: 05.02.15.
10. Rossiiskaya gazeta. 11.06.2013; Spetsvypusk 124/1. URL: http://base.consultant.ru/cons/cgi/online.cgi?req=doc;base=LAW;n=141670;div=LAW;dst=0,0;rnd=0.2839933577924967. Accessed: 05.02.15.
11. Rossiiskaya gazeta. 24.05.2013; Spetsvypusk 110/1. URL: http://base.consultant.ru/cons/cgi/online.cgi?req=doc;base=LAW;n=140711;div=LAW;dst=0,0;rnd=0.6734487896319479. Accessed: 05.02.15.
12. Rossiiskaya gazeta. 24.05.2013; Spetsvypusk 110/1. URL: http://base.consultant.ru/cons/cgi/online.cgi?req=doc;base=LAW;n=140653;div=LAW;dst=0,0;rnd=0.3380826434586197. Accessed: 05.02.15.
13. Rossiiskaya gazeta. 24.05.2013; Spetsvypusk 110/1. URL:http://base.consultant.ru/cons/cgi/online.cgi?req=doc;base=LAW;n=141487;div=LAW;dst=0,0;rnd=0.8763681747950613. Accessed: 05.02.15.
14. Rossiiskaya gazeta. 24.05.2013; Spetsvypusk 110/1. URL: http://base.consultant.ru/cons/cgi/online.cgi?req=doc;base=LAW;n=140760;div=LAW;dst=0,0;rnd=0.6069672594312578. Accessed: 05.02.15.
15. Rossiiskaya gazeta. 24.05.2013; Spetsvypusk 110/1. URL: http://base.consultant.ru/cons/cgi/online.cgi?req=doc;base=LAW;n=140816;div=LAW;dst=0,0;rnd=0.1105802992824465. Accessed: 05.02.15.
16. Rossiiskaya gazeta. 20.06.2013; Spetsvypusk 131/1. URL: http://base.consultant.ru/cons/cgi/online.cgi?req=doc;base=LAW;n=145317;div=LAW;dst=0,0;rnd=0.9855176929850131. Accessed: 05.02.15.
17. Stenina M. B. Practical recommendations on the drug treatment of breast cancer patients. Practical recommendations on the drug treatment of malignant tumors of the Society of Oncologists-chemotherapeutists (RUSSCO). Ed. VM Moiseenko [Prakticheskie rekomendatsii po lekarstvennomu lecheniyu bol’nykh rakom molochnoi zhelezy. Prakticheskie rekomendatsii po lekarstvennomu lecheniyu zlokachestvennykh opukholei Obshchestva onkologov-khimioterapevtov (RUSSCO). Pod red. V. M. Moiseenko. Obshchestvo onkologov-khimioterapevtov (RUSSCO) (in Russian)]. Moscow. 2012; 200 s. URL: http://www.rosoncoweb.ru/standarts/RUSSCO/07-2.pdf. Accessed: 05.02.15.
18. The Federal Law of 21.11.2011 N 323-FZ (ed. Of 12.29.2015) «On the basis of public health protection in the Russian Federation» [Federal’nyi zakon ot 21.11.2011 N 323-FZ (red. ot 29.12.2015) «Ob osnovakh okhrany zdorov’ya grazhdan v Rossiiskoi Federatsii» (in Russian)]. URL: http://www.consultant.ru/document/cons_doc_law_121895/. Accessed: 07.04.2015 g.
19. Formulary Committee of RAMS. Report on the status of the drug provision of the population in the Russian Federation (2008). [Formulyarnyi komitet RAMN. Doklad o sostoyanii lekarstvennogo obespecheniya naseleniya v Rossiiskoi Federatsii (2008 g.) (in Russian)]. Moscow. 2009; 80 s. URL: http: //www.rspor.ru/mods/formular/Report_Formulary_Committee_2008.doc. Accessed: 06.03.15.
20. National Comprehensive Cancer Network, et al. Breast cancer slinical practice guidelines in oncology, version 2. J Natl Compr Canc Netw. 2014; 12: 542-590. URL: http://www.nccn.org/professionals/physician _gls/f_guidelines.asp. Accessed: 05.02.15.
21. The World Health Report: Health Systems Financing; the Path to Universal Coverage. 2010.
For citation:
Avxentyeva M.V., Bogin V.I., Derkach E.V., Omelyanovskiy V.V., Stenina M.B., Tarakanov A.V., Frolov M.Y. DRUGS PROVIDED TO BREAST CANCER PATIENTS WITHIN THE STATE PROGRAMS OF DRUG SUPPLY. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2016;9(3):8-18. (In Russ.) https://doi.org/10.17749/2070-4909.2016.9.3.008-018
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