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The effectiveness of using artificial intelligence in clinical medicine

https://doi.org/10.17749/2070-4909/farmakoekonomika.2025.287

Abstract

Objective: To examine the effectiveness of using artificial intelligence (AI) in clinical medicine (in terms of accuracy, sensitivity, and specificity).

Material and methods. The study involved a search and analysis of scientific publications examining various types of AI training and training approaches, as well as areas of AI application in clinical practice, which were submitted to PubMed/MEDLINE, Scopus, Web of Science, Embase, eLibrary, and CyberLeninka databases in 2009–2023. A sequential analysis of randomly sampled articles yielded 30 publications on the use of AI in endocrinology (4 articles), dermatovenerology (3), cardiology (1), radiology (1), gastroenterology (1), neurology (5), hematology (5), nephrology (4), orthopedics and rheumatology (4), oncology (2).

Results. AI demonstrated sufficient effectiveness: accuracy ranged from 49% to 99%, sensitivity from 42% to 100%, and specificity from 48% to 100% in such areas as cardiology, endocrinology, gastroenterology, dermatovenereology, and radiology. In some cases, AI was more effective than clinical diagnostics by medical specialists, e.g. in detecting melanoma and diagnosing atrial fibrillation.

Conclusion. AI shows high diagnostic efficiency, increases accuracy and speeds up diagnostic search, which makes it promising to expand the use of AI in clinical medicine.

About the Authors

D. I. Korabelnikov
Moscow Haass Medical and Social Institute
Russian Federation

Daniil I. Korabelnikov, PhD, Assoc. Prof.

5 2nd Brestskaya Str., Moscow 123056

 



A. I. Lamotkin
Moscow Haass Medical and Social Institute; Central Research Institute of Organization and Informatization of Healthcare
Russian Federation

Andrey I. Lamotkin 

5 2nd Brestskaya Str., Moscow 123056; 

11 Dobrolyubov Str., Moscow 127254



References

1. Kusters R., Misevic D., Berry H., et al. Interdisciplinary research in artificial intelligence: challenges and opportunities. Front Big Data. 2020; 3: 577974. https://doi.org/10.3389/fdata.2020.577974.

2. Kurakova N.G., Tsvetkova L.A., Cherchenko O.V. Artificial intelligence technologies in medicineand healthcare: Russia's position on the global patent and publication landscape. Medical Doctor and IT. 2020; 2: 81 100 (in Russ.). https://doi.org/10.37690/1811-0193-2020-2-81-100.

3. Jimma B.L. Artificial intelligence in healthcare: a bibliometric analysis. Telemat Inform Rep. 2023; 9 (Suppl. 1): 100041. https://doi.org/10.1016/j.teler.2023.100041.

4. Guo Y., Hao Z., Zhao S., et al. Artificial intelligence in health care: bibliometric analysis. J Med Internet Res. 2020; 22 (7): e18228. https://doi.org/10.2196/18228.

5. Lamotkin A.I., Korabelnikov D.I., Lamotkin I.A., et al. Artificial intelligence in healthcare and medicine: the history of key events, its significance for doctors, the level of development in different countries. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmako epidemiologiya / FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2024; 17 (2): 243–50. https://doi.org/10.17749/2070-4909/farmakoekonomika.2024.254.

6. Hicks S.A., Strümke I., Thambawita V., et al. On evaluation metrics for medical applications of artificial intelligence. Sci Rep. 2022; 12 (1): 5979. https://doi.org/10.1038/s41598-022-09954-8.

7. Solovyev A.A. Weighted error – new metrics for estimating quality of answer validation in the problem of question-answering retrieval. Herald of the Bauman Moscow State Technical University. Series “Instrument Building”. 2013; 1: 58–64 (in Russ.).

8. van Stralen K.J., Stel V.S., Reitsma J.B., et al. Diagnostic methods I: sensitivity, specificity, and other measures of accuracy. Kidney Int. 2009; 75 (12): 1257–63. https://doi.org/10.1038/ki.2009.92.

9. Shreffler J., Huecker M.R. Diagnostic testing accuracy: sensitivity, specificity, predictive values and likelihood ratios. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.

10. Çorbacıoğlu Ş.K., Aksel G. Receiver operating characteristic curve analysis in diagnostic accuracy studies: a guide to interpreting the area under the curve value. Turk J Emerg Med. 2023; 23 (4): 195–8. https://doi.org/10.4103/tjem.tjem_182_23.

11. Zhou J., Gandomi A., Chen F., Holzinger A. Evaluating the quality of machine learning explanations: a survey on methods and metrics. Electronics. 2021; 10 (5): 593. https://doi.org/10.3390/electronics10050593.

12. Attia Z.I., Noseworthy P.A., Lopez-Jimenez F., et al. An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction. Lancet. 2019; 394 (10201): 861–7. https://doi.org/10.1016/S0140-6736(19)31721-0.

13. Gulshan V., Peng L., Coram M., et al. Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA. 2016; 316 (22): 2402–10. https://doi.org/10.1001/jama.2016.17216.

14. Sudharsan B., Peeples M., Shomali M. Hypoglycemia prediction using machine learning models for patients with type 2 diabetes. J Diabetes Sci Technol. 2015; 9 (1): 86–90. https://doi.org/10.1177/1932296814554260.

15. Pei X., Yao X., Yang Y., et al. Efficacy of artificial intelligence-based screening for diabetic retinopathy in type 2 diabetes mellitus patients. Diabetes Res Clin Pract. 2022; 184: 109190. https://doi.org/10.1016/j.diabres.2022.109190.

16. Marling C.R., Struble N.W., Bunescu R.C., et al. A consensus perceived glycemic variability metric. J Diabetes Sci Technol. 2013; 7 (4): 871–9. https://doi.org/10.1177/193229681300700409.

17. Nam J.G., Park S., Hwang E.J., et al. Development and validation of deep learning-based automatic detection algorithm for malignant pulmonary nodules on chest radiographs. Radiology. 2019; 290 (1): 218–28. https://doi.org/10.1148/radiol.2018180237.

18. Misawa M., Kudo S.E., Mori Y., et al. Artificial intelligence-assisted polyp detection for colonoscopy: initial experience. Gastroenterology. 2018; 154 (8): 2027–9.e3. https://doi.org/10.1053/j.gastro.2018.04.003.

19. Brinker T.J, Hekler A., Enk A.H., et al. A convolutional neural network trained with dermoscopic images performed on par with 145 dermatologists in a clinical melanoma image classification task. Eur J Cancer. 2019; 111: 148–54. https://doi.org/10.1016/j.ejca.2019.02.005.

20. Esteva A., Kuprel B., Novoa R.A., et al. Dermatologist-level classification of skin cancer with deep neural networks. Nature. 2017; 542 (7639): 115–8. https://doi.org/10.1038/nature21056.

21. Han S.S., Park G.H., Lim W., et al. Deep neural networks show an equivalent and often superior performance to dermatologists in onychomycosis diagnosis: automatic construction of onychomycosis datasets by region-based convolutional deep neural network. PLoS One. 2018; 13 (1): e0191493. https://doi.org/10.1371/journal.pone.0191493.

22. Abedi V., Avula V., Chaudhary D., et al. Prediction of long-term stroke recurrence using machine learning models. J Clin Med. 2021; 10 (6): 1286. https://doi.org/10.3390/jcm10061286.

23. Daoud H., Bayoumi M.A. Efficient epileptic seizure prediction based on deep learning. IEEE Transact Biomed Circuits Syst. 2019; 13 (5): 804–13. https://doi.org/10.1109/TBCAS.2019.2929053.

24. Qiu S., Joshi P.S., Miller M.I., et al. Development and validation of an interpretable deep learning framework for Alzheimer’s disease classification. Brain. 2020; 143 (6): 1920–33. https://doi.org/10.1093/brain/awaa137.

25. Rava R.A., Seymour S.E., Snyder K.V., et al. Automated collateral flow assessment in patients with acute ischemic stroke using computed tomography with artificial intelligence algorithms. World Neurosurg. 2021; 155: e748–60. https://doi.org/10.1016/j.wneu.2021.08.136.

26. Shinde R., Gupta D., Bansal S., et al. Predictive modeling for stroke outcomes: a comparison of machine learning algorithms. NeuroImage. 2021; 227: 117726. https://doi.org/10.1016/j.neuroimage.2020.117726.

27. Boldú L., Merino A., Acevedo A., et al. A deep learning model (ALNet) for the diagnosis of acute leukaemia lineage using peripheral blood cell images. Comput Methods Programs Biomed. 2021; 202: 105999. https://doi.org/10.1016/j.cmpb.2021.105999.

28. El Hussein S., Chen P., Medeiros L.J., et al. Artificial intelligence assisted mapping of proliferation centers allows the distinction of accelerated phase from large cell transformation in chronic lymphocytic leukemia. Mod Pathol. 2022; 35 (8): 1121–5. https://doi.org/10.1038/s41379-022-01015-9.

29. AlAgha A.S., Faris H., Hammo B.H., Al-Zoubi A.M. Identifying β-thalassemia carriers using a data mining approach: the case of the Gaza Strip, Palestine. Artif Intel Med. 2018; 88: 70–83. https://doi.org/10.1016/j.artmed.2018.04.009.

30. Didi I., Simoncini D., Vergez F., et al. Artificial intelligence-based predictive models for acute myeloid leukemia. Blood. 2021; 138 (Suppl. 1): 3389. https://doi.org/10.1182/blood-2021-145122.

31. Memmolo P., Aprea G., Bianco V., et al. Differential diagnosis of hereditary anemias from a fraction of blood drop by digital holography and hierarchical machine learning. Biosens Bioelectron. 2022; 201: 113945. https://doi.org/10.1016/j.bios.2021.113945.

32. Tomašev N., Glorot X., Rae J.W., et al. A clinically applicable approach to continuous prediction of future acute kidney injury. Nature. 2019; 572 (7767): 116–9. https://doi.org/10.1038/s41586-019-1390-1.

33. Mohamadlou H., Lynn-Palevsky A., Barton C., et al. Prediction of acute kidney injury with a machine learning algorithm using electronic health record data. Can J Kidney Health Dis. 2018; 5: 2054358118776326. https://doi.org/10.1177/2054358118776326.

34. Adhikari L., Ozrazgat-Baslanti T., Ruppert M., et al. Improved predictive models for acute kidney injury with IDEA: Intraoperative Data Embedded Analytics. PLoS One. 2019; 14 (4): e0214904. https://doi.org/10.1371/journal.pone.0214904.

35. Kuo C.C., Chang C.M., Liu K.T., et al. Automation of the kidney function prediction and classification through ultrasound-based kidney imaging using deep learning. NPJ Digit Med. 2019; 2: 29. https://doi.org/10.1038/s41746-019-0104-2.

36. Couteaux V., Si-Mohamed S., Nempont O., et al. Automatic knee meniscus tear detection and orientation classification with Mask-RCNN. Diagn Interv Imaging. 2019; 100 (4): 235–42. https://doi.org/10.1016/j.diii.2019.03.002.

37. Rouzrokh P., Ramazanian T., Wyles C.C., et al. Deep learning artificial intelligence model for assessment of hip dislocation risk following primary total hip arthroplasty from postoperative radiographs. J Arthroplasty. 2021; 6 (6): 2197–203.e3. https://doi.org/10.1016/j.arth.2021.02.028.

38. Patrick M.T., Stuart P.E., Raja K. et al. Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients. Nat Commun. 2018; 9 (1): 4178. https://doi.org/10.1038/s41467-018-06672-6.

39. Long N.P., Park S., Anh N.H., et al. Efficacy of integrating a novel 16-gene biomarker panel and intelligence classifiers for differential diagnosis of rheumatoid arthritis and osteoarthritis. J Clin Med. 2019; 8 (1): 50. https://doi.org/10.3390/jcm8010050.

40. Lu J., Liu R., Zhang Y., et al. Development and application of a detection platform for colorectal cancer tumor sprouting pathological characteristics based on artificial intelligence. Intel Med. 2022; 2 (2): 82–7. https://doi.org/10.1016/j.imed.2021.08.003.

41. Pantanowitz L., Quiroga-Garza G.M., Bien L., et al. An artificial intelligence algorithm for prostate cancer diagnosis in whole slide images of core needle biopsies: a blinded clinical validation and deployment study. Lancet Digit Health. 2020; 2 (8): e407-e416. https://doi.org/10.1016/S2589-7500(20)30159-X.


Supplementary files

1. Supplement 1. The effectiveness of artificial intelligence according to the publications included in the review (n=30)
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Indexing metadata ▾

What is already known about thе subject?

Artificial intelligence (AI) is actively implemented in medicine, which provides more accurate diagnostics and effective treatment of various diseases

Machine learning and deep learning are used to analyze clinical data, predict the development of diseases and their complications, and develop telemedicine technologies

The effectiveness of AI in medicine is assessed in terms of the error matrix, weighted errors, accuracy, sensitivity, specificity, area under curve, and the Youden index

What are the new findings?

The potential of AI was analyzed, and examples of its successful application in some areas of medicine were given (e.g. cardiology, endocrinology, gastroenterology, dermatovenereology, neurology, hematology, nephrology, oncology and orthopedics, rheumatology)

The study results were presented, which indicate the high effectiveness of AI as compared to conventional diagnostic methods

How might it impact the clinical practice in the foreseeable future?

The use of AI in medicine can increase the diagnosis accuracy and treatment efficacy, which will improve the quality of medical care and reduce its costs

Choosing the right approach to AI training in medicine can improve the diagnostic and treatment outcomes of various diseases

The results of applied research show that AI can be used in the form of computer programs and smartphone applications as well as in telemedicine services as part of the clinical decision support system

Review

For citations:


Korabelnikov D.I., Lamotkin A.I. The effectiveness of using artificial intelligence in clinical medicine. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2025;18(1):114-124. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2025.287

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ISSN 2070-4909 (Print)
ISSN 2070-4933 (Online)