Epigenetic aspects in rehabilitation of female cancer patients
A. G. Solopova,
D. V. Blinov,
S. V. Demyanov,
G. V. Demyanov,
E. E. Achkasov,
A. Yu. Vlasina,
L. N. Sandzhieva,
D. M. Ampilogova https://doi.org/10.17749/2070-4909/farmakoekonomika.2022.141
Abstract
The influence of epigenetic processes on the development of malignant diseases, including gynaecological cancers, is now beyond doubt. DNA methylation, histone modification and post-transcriptional regulation by microRNAs lead to changes in the activity of various genes, contributing to female genital cancers (cervix, endometrium, ovarian). It should be noted that disruptions in gene expression do not only occur in malignant cells, but also in the tumour microenvironment, resulting in disease progression and relapse. However, “epigenetic markers” of carcinogenesis can be useful in the treatment and rehabilitation of patients, making a personalized approach possible.
About the Authors
A. G. Solopova
Sechenov University
Russian Federation
Russian Federation
Antonina G. Solopova – Dr. Med. Sc., Professor, Chair of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health. Scopus Author ID: 6505479504; WoS ResearcherID: Q-1385-2015; RSCI SPIN-code: 5278-0465
8/2 Trubetskaya Str., Moscow 119991
D. V. Blinov
Institute for Preventive and Social Medicine; Lapino Clinical Hospital, Medical Group “Mother and Child”; Moscow Haass Medical Social Institute
Russian Federation
Russian Federation
Dmitry V. Blinov – MD, PhD, MBA, Head of Medical and Scientific Affairs; Neurologist; Faculty Member, Chair of Neurology, Psychiatry and Narcology. WoS ResearcherID: J-4946-2017; Scopus Author ID: 7003589812; RSCI SPIN-code: 6317-9833
4/10 Sadovaya-Triumfalnaya Str., Moscow 127006
111 1st Uspenskoye Hwy, Moscow Region, Odintsovo District, Lapino 143081
5 bldg 1-1a 2nd Brestskaya Str., Moscow 123056
S. V. Demyanov
Sechenov University
Russian Federation
Russian Federation
Semen V. Demyanov – 5th Year Student
8/2 Trubetskaya Str., Moscow 119991
G. V. Demyanov
Sechenov University
Russian Federation
Russian Federation
Gleb V. Demyanov – 5th Year Student
8/2 Trubetskaya Str., Moscow 119991
E. E. Achkasov
Sechenov University
Russian Federation
Russian Federation
Evgeniy E. Achkasov – Dr. Med. Sc., Professor, Head of Department of Sports Medicine and Rehabilitation. RSCI SPIN-code: 5291-0906
8/2 Trubetskaya Str., Moscow 119991
A. Yu. Vlasina
Sechenov University
Russian Federation
Russian Federation
Anastasia Yu. Vlasina – Postgraduate, Chair of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health. WoS ResearcherID: AAF-3130-2020; Scopus Author ID: 1016902; RSCI SPIN-code: 1496-6522
8/2 Trubetskaya Str., Moscow 119991
L. N. Sandzhieva
Sechenov University
Russian Federation
Russian Federation
Lidiya N. Sandzhieva – Postgraduate, Chair of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health. RSCI SPIN-code: 7228-3726
8/2 Trubetskaya Str., Moscow 119991
D. M. Ampilogova
Sechenov University
Russian Federation
Russian Federation
Diana M. Ampilogova – MD, Clinical Resident, Chair of Obstetrics and Gynecology, Sklifosovsky Institute of Clinical Medicine
8/2 Trubetskaya Str., Moscow 119991
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Solopova A.G., Blinov D.V., Demyanov S.V., Demyanov G.V., Achkasov E.E., Vlasina A.Yu., Sandzhieva L.N., Ampilogova D.M. Epigenetic aspects in rehabilitation of female cancer patients. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2022;15(2):294-303. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2022.141
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