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Modern achievements in pharmacotherapy of osteoarthritis based on endo- and phenotyping

https://doi.org/10.17749/2070-4909/farmakoekonomika.2021.105

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Abstract

The review of medical literature is devoted to modern data in the field of diagnosis and treatment of osteoarthritis using endo- and phenotyping. It includes the latest data on the epidemiology of osteoarthritis of different localizations, modern definitions and classifications of osteoarthritis endotypes and phenotypes, pathobiochemical patterns and pathomorphological parallels of disease phenotypes, new methodological approaches to the phenotyping of osteoarthritis (prognostic, prescriptive phenotyping, alternative methods), as well as modern advances in pharmacotherapy of the disease based on data from selected randomized controlled trials and meta-analyzes.

About the Authors

I. V. Sarvilina
Medical Centre “Novomeditsina”
Russian Federation

Irina V. Sarvilina – Dr. Med. Sc., Clinical Pharmacologist, Chief Physician

RSCI SPIN-code: 7308-6756

74 Sotsialisticheskaya, Rostov-on-Don 344002, Russia



O. A. Shavlovskaya
International University of Restorative Medicine
Russian Federation

Olga А. Shavlovskaya – Dr. Med. Sc., Professor, Chair of Organization of Medical Rehabilitation and Sanatorium-Resort Treatment

WoS ResearcherID: V-4470-2018; Scopus Author ID: 15124744300; RSCI SPIN-code: 5300-4282 

8/2 Furmannyy Al., Moscow 105062, Russia



O. A. Gromova
Institute of Pharmacoinformatics, Federal Research Center “Informatics and Management”, Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation

Olga A. Gromova – Dr. Med. Sc., Professor, Research Supervisor; Leading Researcher

Scopus Author ID: 7003589812; WoS ResearcherID: J-4946-2017; RSCI SPIN-code: 6317-9833 

4 Vavilov Str., Moscow 2119333, Russia 

1 Leninskie Gory, Moscow 119991, Russia



A. V. Naumov
Pirogov Russian National Research Medical University
Russian Federation

Anton V. Naumov – Dr. Med. Sc., Professor, Chair of Diseases of Aging

16 Pervaya Leonov Str., Moscow 129226, Russia



M. N. Sharov
Yevdokimov Moscow State University of Medicine and Dentistry; Spasokukotskiy City Clinical Hospital
Russian Federation

Mikhail N. Sharov – Dr. Med. Sc., Professor, Chair of Nervous Diseases, Faculty of Dentistry; Head

Scopus Author ID: 57212167091; RSCI SPIN-code: 8506-6900 

10 bld. 2 Delegatskaya Str., Moscow 127473, Russia

21 Vuchetich Str., Moscow 127206, Russia



Yu. S. Prokofyeva
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Yulia S. Prokofyeva – Postgraduate, Chair of Nervous Diseases, Faculty of Dentistry

Scopus Author ID: 57216579623; RSCI SPIN-code: 8789-3644

10 bld. 2 Delegatskaya Str., Moscow 127473, Russia



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For citation:


Sarvilina I.V., Shavlovskaya O.A., Gromova O.A., Naumov A.V., Sharov M.N., Prokofyeva Yu.S. Modern achievements in pharmacotherapy of osteoarthritis based on endo- and phenotyping. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2021;14(3):379-406. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2021.105

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