FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology

Advanced search

Systematic computer analysis of published literature on nutritional support for vaccination

Full Text:


A range of 6700 publications from the PubMed database on the association of micronutrient supply and results of antibacterial and antiviral vaccination was reviewed by the method of topologic and metric analysis. This method allows for a selection of features (i.e. key words) by their informativity, the establishment of the most informative that provide the basis for “synthetic” features and algorithms, or the classification of the reviewed text by the relevance to the subject of the study. The results of fundamental studies showed that folates, vitamins A, D, and B12 are the regulators of mitosis of T and B-lymphocytes that exert the functions of the acquired immunity. Such microelements as zinc, iron, selenium, manganese, and omega-3 polyunsaturated fatty acid support the functioning of T and B-lymphocytes (energy metabolism, intracellular signal transmission, and transcription). Clinical studies showed that the support of vaccination with the specified micronutrients not only increases the titre of the respective antibodies to viral and bacterial pathogens but can also prevent unfavorable effects from vaccination. The administration of micronutrients before and after vaccination will contribute to a decrease in the mortality rate and severity of the pathology development (in case of disease). A systematic analysis allowed the authors to determine the perspectives of the proposed measures for an increase in the effectiveness and safety of vaccines, including COVID-19. Additional micronutrient supply contributes to an increase in the effectiveness and safety of vaccination. The application of specialized vitamin and mineral complexes during vaccination is economically feasible and reduces the vaccination risks for patients with polyhypoavitaminoses.

About the Authors

A. G. Chuchalin
Pirogov Russian National Research Medical University
Russian Federation

Aleksandr G. Chuchalin – Dr. Med. Sc., Professor, Academician of RAS, Pulmonologist, Head of Chair of Hospital Therapy, Faculty of Pediatrics

16 Pervaya Leonov Str., Moscow 129226, Russia

I. Yu. Torshin
Institute of Pharmacoinformatics, Federal Research Center “Informatics and Management”, Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation

Ivan Yu. Torshin – PhD (Phys. Math.), PhD (Chem.), Senior Researcher. Scopus Author ID: 7003300274; WoS ResearcherID: C-7683-2018; RSCI SPIN-code: 1375-1114

4 Vavilov Str., Moscow 2119333, Russia
1 Leninskie Gory, Moscow 119991, Russia

O. A. Gromova
Institute of Pharmacoinformatics, Federal Research Center “Informatics and Management”, Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation

Olga A. Gromova – Dr. Med. Sc., Professor, Research Supervisor; Leading Researcher, Big Data Storage and Analysis Center.  Scopus Author ID: 7003589812; WoS ResearcherID: J-4946-2017; RSCI SPIN-code: 6317-9833

4 Vavilov Str., Moscow 2119333, Russia
1 Leninskie Gory, Moscow 119991, Russia


1. Singh A.K., Khunti K. Assessment of risk, severity, mortality, glycemic control and antidiabetic agents in patients with diabetes and COVID-19: a narrative review. Diabetes Res Clin Pract. 2020; 165: 108266.

2. Torshin I.Yu., Gromova О.А. 25 moments of molecular pharmacology. On the development of clinical and pharmacological thinking. Russian Center of the UNESCO Institute of Trace Elements. Ivanovo: A-Gref; 2012 (in Russ.).

3. Limanova O.A., Torshin I.Yu., Sardaryan I.S., et al. Micronutrient provision and women’s health: intellectual analysis of clinicoepidemiological data. Gynecology, Obstetrics and Perinatology. 2014; 13 (2): 5–15 (in Russ.).

4. Torshin I.Yu., Limanova O.A., Gromova O.A., et al. Metric analysis of data on relationship between indicators of micronutrient provision and state of health of women aged 18–45 years. Medical Alphabet. 2018; 2 (21): 6–19 (in Russ.).

5. Torshin I.Y., Gromova O.A., Limanova O.A., et al. Role of micronutrients sufficiency in health maintaining of children and adolescents: analysis of a large-scale sample of patients through data mining. Journal “Pediatria” named after G.N. Speransky. 2015; 94 (6): 68–78 (in Russ.).

6. Surman S.L., Penkert R.R., Jones B.G., et al. Vitamin supplementation at the time of immunization with a cold-adapted influenza virus vaccine corrects poor mucosal antibody responses in mice deficient for vitamins A and D. Clin Vaccine Immunol. 2016; 23 (3): 219–27.

7. Penkert R.R., Rowe H.M., Surman S.L., et al. Influences of vitamin A on vaccine immunogenicity and efficacy. Front Immunol. 2019; 10: 1576.

8. Raahati Z., Bakhshi B., Najar-Peerayeh S. Selenium nanoparticles induce potent protective immune responses against vibrio cholerae WC vaccine in a mouse model. J Immunol Res. 2020; 2020: 8874288.

9. Behzadi M., Vakili B., Ebrahiminezhad A., Nezafat N. Iron nanoparticles as novel vaccine adjuvants. Eur J Pharm Sci. 2021; 159: 105718.

10. Patel S., Akalkotkar A., Bivona J.J. 3rd, et al. Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice by induction of early interleukin-15 but not interleukin-1β responses. Immunology. 2016; 148 (4): 352–62.

11. Torshin I.Yu., Gromova О.А. Micronutrients against coronaviruses. Мoscow: GEOTAR-Media; 2020 (in Russ.).

12. Torshin I.Yu., Gromova О.А., Chuchalin А.G., Zhuravlev Yu.I. Chemoreactome screening of pharmaceutical effects on SARSCoV-2 and human virome to help decide on drug-based COVID-19 therapy. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2021; 14 (2): 191–211 (in Russ.).

13. Gromova О.А., Torshin I.Yu. Micronutrients and reproductive health. Guide. Мoscow: GEOTAR-Media; 2019 (in Russ.).

14. Gromova О.А., Torshin I.Yu. Magnesium and “diseases of civilization”. Мoscow: GEOTAR-Media; 2018 (in Russ.).

15. Torshin I.Yu., Rudakov K.V. On the theoretical basis of the metric analysis of poorly formalized problems of recognition and classification. Pattern Recognition and Image Analysis. 2015; 25 (4): 577–87.

16. Torshin I.Yu., Rudakov K.V. On the procedures of generation of numerical features over partitions of sets of objects in the problem of predicting numerical target variables. Pattern Recognition and Image Analysis. 2019; 29 (4): 654–67.

17. Torshin I.Yu., Rudakov K.V. Topological data analysis in materials science: the case of high-temperature cuprate superconductors. Pattern Recognition and Image Analysis. 2020; 30 (2): 262–74.

18. Torshin I.Yu., Gromova O.A., Stakhovskaya L.V., et al. Analysis of 19.9 million publications from the PubMed/MEDLINE database using artificial intelligence methods: approaches to the generalizations of accumulated data and the phenomenon of “fake news”. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020; 13 (2): 146–63 (in Russ.).

19. Gromova O.A., Torshin I.Yu., Tetruashvili N.K., et al. Vitamin A in obstetrics: basic and clinical research. Medical Alphabet. 2019; 1 (1): 59–69 (in Russ.).

20. Penkert R.R., Cortez V., Karlsson E.A., et al. Vitamin A Corrects Tissue Deficits in Diet-Induced Obese Mice and Reduces Influenza Infection After Vaccination and Challenge. Obesity (Silver Spring). 2020; 28 (9): 1631–6.

21. Surman S.L., Jones B.G., Sealy R.E., et al. Oral retinyl palmitate or retinoic acid corrects mucosal IgA responses toward an intranasal influenza virus vaccine in vitamin A deficient mice. Vaccine. 2014; 32 (22): 2521–4.

22. Ahmad S.M., Alam M.J., Khanam A., et al. Vitamin A supplementation during pregnancy enhances pandemic H1N1 vaccine response in mothers, but enhancement of transplacental antibody transfer may depend on when mothers are vaccinated during pregnancy. J Nutr. 2018; 148 (12): 1968–75.

23. McGill J.L., Kelly S.M., Guerra-Maupome M., et al. Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves. Sci Rep. 2019; 9 (1): 15157.

24. Jee J., Hoet A.E., Azevedo M.P., et al. Effects of dietary vitamin A content on antibody responses of feedlot calves inoculated intramuscularly with an inactivated bovine coronavirus vaccine. Am J Vet Res. 2013; 74 (10): 1353–62.

25. Kaufman D.R., De Calisto J., Simmons N.L., et al. Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity. J Immunol. 2011; 187 (4): 1877–83.

26. Kandasamy S., Chattha K.S., Vlasova A.N., Saif L.J. Prenatal vitamin A deficiency impairs adaptive immune responses to pentavalent rotavirus vaccine (RotaTeq®) in a neonatal gnotobiotic pig model. Vaccine. 2014; 32 (7): 816–24.

27. Chattha K.S., Kandasamy S., Vlasova A.N., Saif L.J. Vitamin A deficiency impairs adaptive B and T cell responses to a prototype monovalent attenuated human rotavirus vaccine and virulent human rotavirus challenge in a gnotobiotic piglet model. PLoS One. 2013; 8 (12): e82966.

28. Ma A.Q., Wang Z.X., Sun Z.Q., et al. Interventional effect of vitamin A supplementation on re-vaccination to hepatitis B virus among rural infants and young children in China. Zhonghua Yu Fang Yi Xue Za Zhi. 2011; 45 (3): 259–62.

29. Penkert R.R., Iverson A., Rosch J.W., Hurwitz J.L. Prevnar-13 vaccine failure in a mouse model for vitamin A deficiency. Vaccine. 2017; 35 (46): 6264–8.

30. Zheng Y., Li X.G., Wang Q.Z., et al. Enhancement of vitamin A combined vitamin D supplementation on immune response to Bacille Calmette-Guérin vaccine revaccinated in Chinese infants. Asian Pac J Trop Med. 2014; 7 (2): 130–5.

31. Newton S., Owusu-Agyei S., Filteau S., et al. Vitamin A supplements are well tolerated with the pentavalent vaccine. Vaccine. 2008; 26 (51): 6608–13.

32. Sudfeld C.R., Navar A.M., Halsey N.A. Effectiveness of measles vaccination and vitamin A treatment. Int J Epidemiol. 2010; 39 (Suppl. 1): i48–55.

33. Bahl R., Bhandari N., Kant S., et al. Effect of vitamin A administered at Expanded Program on Immunization contacts on antibody response to oral polio vaccine. Eur J Clin Nutr. 2002; 56 (4): 321–5.

34. Rahman M.M., Mahalanabis D., Hossain S., et al. Simultaneous vitamin A administration at routine immunization contact enhances antibody response to diphtheria vaccine in infants younger than six months. J Nutr. 1999; 129 (12): 2192–5.

35. Gromova O.A., Torshin I.Yu. Vitamin D. Paradigm shift. 2nd ed. Мoscow: GEOTAR-Media; 2021 (in Russ.).

36. Kashi D.S., Oliver S.J., Wentz L.M., et al. Vitamin D and the hepatitis B vaccine response: a prospective cohort study and a randomized, placebo-controlled oral vitamin D(3) and simulated sunlight supplementation trial in healthy adults. Eur J Nutr. 2021; 60 (1): 475–91.

37. Patel N., Penkert R.R., Jones B.G., et al. Baseline serum vitamin A and D levels determine benefit of oral vitamin A&D supplements to humoral immune responses following pediatric influenza vaccination. Viruses. 2019; 11 (10): 907.

38. Lee M.D., Lin C.H., Lei W.T., et al. Does vitamin D deficiency affect the immunogenic responses to influenza vaccination? A systematic review and meta-analysis. Nutrients. 2018; 10 (4): 409.

39. Mohta A., Kushwaha R.K., Gautam U., et al. A comparative study of the efficacy and safety of intralesional measles, mumps, and rubella vaccine versus intralesional vitamin D3 for the treatment of warts in children. Pediatr Dermatol. 2020; 37 (5): 853–9.

40. Zhao X., Pang X., Wang F., et al. Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infants. Hum Vaccin Immunother. 2018; 14 (10): 2478–84.

41. Siddiqua T.J., Ahmad S.M., Ahsan K.B., et al. Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh. Eur J Nutr. 2016; 55 (1): 281–93.

42. Gromova O.A., Torshin I.Yu. Zinc as essential element of prevention of congenital fetal malformations. Medical Alphabet. 2016; 1 (7): 19–25 (in Russ.).

43. Gromova O.A., Torshin I.Yu., Moiseev V.S., et al. The use of zinc and vitamin с for the prevention and adjuvant therapy of acute respiratory diseases. Therapy. 2017; 1: 36–46 (in Russ.).

44. Gromova O., Shilyaev R., Torshin I., et al. Various ways of the organic zinc salts administration with a colostrum in frequently and protractedly sick children. Pediatric Pharmacology. 2009; 6 (1): 37–42 (in Russ.).

45. Zhao N., Wang X., Zhang Y., et al. Gestational zinc deficiency impairs humoral and cellular immune responses to hepatitis B vaccination in offspring mice. PLoS One. 2013; 8 (9): e73461.

46. Shi L., Zhang L., Li C., et al. Dietary zinc deficiency impairs humoral and cellular immune responses to BCG and ESAT-6/CFP-10 vaccination in offspring and adult rats. Tuberculosis (Edinb). 2016; 97: 86–96.

47. Ozgenc F., Aksu G., Kirkpinar F., et al. The influence of marginal zinc deficient diet on post-vaccination immune response against hepatitis B in rats. Hepatol Res. 2006; 35 (1): 26–30.

48. Das R., Jobayer Chisti M., Ahshanul Haque M., et al. Evaluating association of vaccine response to low serum zinc and vitamin D levels in children of a birth cohort study in Dhaka. Vaccine. 2021; 39 (1): 59–67.

49. Lazarus R.P., John J., Shanmugasundaram E., et al. The effect of probiotics and zinc supplementation on the immune response to oral rotavirus vaccine: a randomized, factorial design, placebo-controlled study among Indian infants. Vaccine. 2018; 36 (2): 273–9.

50. Gromova О.А., Gogoleva I.V. Selenium – impressive results and application prospects. Difficult Patient. 2007; 5 (14): 25–30 (in Russ.).

51. Shojadoost B., Taha-Abdelaziz K., Alkie T.N., et al. Supplemental dietary selenium enhances immune responses conferred by a vaccine against low pathogenicity avian influenza virus. Vet Immunol Immunopathol. 2020; 227: 110089.

52. Ivory K., Prieto E., Spinks C., et al. Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults. Clin Nutr. 2017; 36 (2): 407–15.

53. Janbakhsh A., Mansouri F., Vaziri S., et al. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients. Caspian J Intern Med. 2013; 4 (1): 603–6.

54. Yathapu S.R., Kondapalli N.B., Srivalliputturu S.B., et al. Effect of lead exposure and nutritional iron-deficiency on immune response: a vaccine challenge study in rats. J Immunotoxicol. 2020; 17 (1): 144–52.

55. Stoffel N.U., Uyoga M.A., Mutuku F.M., et al. Iron deficiency anemia at time of vaccination predicts decreased vaccine response and iron supplementation at time of vaccination increases humoral vaccine response: a birth cohort study and a randomized trial follow-up study in Kenyan infants. Front Immunol. 2020; 11: 1313.

56. Burin A.M. Jr., Fernandes N.L., Snak A., et al. Arginine and manganese supplementation on the immune competence of broilers immune stimulated with vaccine against Salmonella Enteritidis. Poult Sci. 2019; 98 (5): 2160–8.

57. Furuhjelm C., Jenmalm M.C., Fälth-Magnusson K., Duchén K. Th1 and Th2 chemokines, vaccine-induced immunity, and allergic disease in infants after maternal ω-3 fatty acid supplementation during pregnancy and lactation. Pediatr Res. 2011; 69 (3): 259–64.

For citation:

Chuchalin A.G., Torshin I.Yu., Gromova O.A. Systematic computer analysis of published literature on nutritional support for vaccination. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2021;14(2):249–262. (In Russ.)

Views: 90

ISSN 2070-4909 (Print)
ISSN 2070-4933 (Online)