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Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosis

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Treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is a current problem worldwide. Currently, special attention is paid to the possibility of using new high-cost chemotherapy regimens in the treatment of MDR/XDR-TB. Numerous studies have shown that, from a clinical point of view, the effectiveness of MDR/XDR-TB therapy increases with the inclusion of bedaquiline, delamanid, linezolid, fluoroquinolones (moxifloxacin, levofloxacin), and pretomanid. At the same time, there is an assumption that the use of new and repurposed anti-tuberculosis drugs (ATDs) may be associated with an increase in overall costs. This paper demonstrates the potential of pharmacoepidemiology and pharmacoeconomics to evaluate the widespread introduction of new anti-tuberculosis drugs (ATDs), taking into account all the typical features of MDR/XDR-TB therapy. The authors analyzed studies of pharmacoeconomic feasibility of using expensive drugs in treatment regimens of pulmonary tuberculosis patients with MDR/XDR pathogen. It was shown that the use of chemotherapy regimens containing new high-cost and highly effective drugs (moxifloxacin, linizolid, and bedaquiline) in rational combinations with other drugs of the basic and reserve series, selected concerning drug resistance of the pathogen, is associated with a significant economic effect. From the applicability of pharmacoeconomic analysis point of view, the introduction of short-term MDR-TB treatment regimens is also a promising direction in phthisiology. The key link to achieve effective MDR/XDR-TB treatment is the use of new drugs. Considering the specificity of pharmacoeconomic analysis in phthisiology and results of existing clinical and economic studies, the authors have formed recommendations aimed at a more complete realization of pharmacoeconomic analysis potential in MDR- and XDR-TB treatment.

About the Authors

N. Yu. Nikolenko
Moscow Scientific and Practical Center for Tuberculosis Control
Russian Federation

Nikolay Yu. Nikolenko – Researcher, Scientific and Clinical Department. RSCI SPIN-code: 5011-4166

10 Stromynka Str., Moscow 107014, Russia

D. А. Kudlay
Sechenov University; State Research Center “Institute of Immunology”; Federal Medical and Biological Agency of Russia
Russian Federation

Dmitry A. Kudlay – Dr. Med. Sc., Professor, Chair of Pharmacology, Nelyubin Institute of Pharmacy; Leading Researcher, Laboratory of Personalized Medicine and Molecular Immunology No. 71.  Scopus Author ID: 57201653374; RSCI SPIN-code: 4129-7880

8/2 Trubetskaya Str., Moscow 119991, Russia
24 Kashirskoye Shosse, Moscow 115522, Russia

N. P. Doktorova
National Research Medical Center for Phthisiopulmonology and Infectious Diseases
Russian Federation

Natalia P. Doktorova – PhD (Med.), Researcher, Department of Differential Diagnosis and Treatment of Tuberculosis and Combined Infections. Scopus Author ID: 21733662400; RSCI SPIN-code: 5791-6542

4 corp. 2 Dostoyevskiy Str., Moscow 127473, Russia


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For citation:

Nikolenko N.Yu., Kudlay D.А., Doktorova N.P. Pharmacoepidemiology and pharmacoeconomics of multidrug- and extensively drug-resistant tuberculosis. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2021;14(2):235–248. (In Russ.)

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