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COVID-19 pandemic: protective role of vitamin D

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Introduction. The COVID-19 pandemic revealed the vulnerability of the general population to this infectious disease, which is determined by the lack of immunity to the new SARS-CoV-2 coronavirus and is characterized by cytokine storm in severe cases. One of the most important reasons for this vulnerability is a high occurrence rate of micronutrient deficiencies, and above all, vitamin D deficiency.

Aim. To systematize the available data on the role of vitamin D in the prevention of COVID-19 infection.

Materials and methods. Systematic computer analysis of the entire array of available scientific publications on coronaviruses (21,300 publications in PUBMED and preprint repositories, including 7,500 publications on COVID-19 and SARS-CoV-2) was performed. The methods of topological and metric data analysis were used. About 50 most informative sections were identified that were mainly associated with COVID-19 / SARS-CoV-2. The analysis of the obtained “map” of molecular pathophysiology of COVID-19 was performed.

Results. Vitamin D activates the expression of many genes involved in supporting the immunity against coronaviruses and other singlestranded RNA viruses (interferon-dependent protection). The results of the systematic analysis of the publications on coronavirus showed that vitamin D is important for attenuating the effects of the cytokine storm and compensating for chronic comorbid pathologies.

Conclusion. The compensation for vitamin D deficiency is an essential component of COVID-19 prevention. This tactics of prevention is less costly than managing patients with severe forms of COVID-19 and can help save public healthcare resources.  

About the Authors

O. A. Gromova
V.A. Nasonov Research Institute of Rheumatology; Federal Research Center “Informatics and Management of the Russian Academy of Sciences“
Russian Federation

MD, Dr Sci Med, Professor, Senior Researcher, Scientific Director; Leading Researcher, Center for Big Data Analysis, Moscow State University

Author ID: 94901; Scopus Author ID: 7003589812;

WoS ResearcherID: J-4946-2017. RSCI SPIN-code: 6317-9833

34A Kashirskoye Shosse, Moscow 115522, Russia

44-2 Vavilova Str., Moscow 119333, Russia

I. Yu. Torshin
V.A. Nasonov Research Institute of Rheumatology; Federal Research Center “Informatics and Management of the Russian Academy of Sciences“
Russian Federation

MD, PhD, Senior Researcher, Federal Research Center “Informatics and Management”; Big Data Storage and Analysis Center,

Scopus Author ID: 7003300274; Author ID: 54104;

WoS ResearcherID: C-7683-2018. RSCI SPIN-code: 1375-1114

34A Kashirskoye Shosse, Moscow 115522, Russia

44-2 Vavilova Str., Moscow 119333, Russia

G. Kh. Gabdulina
Kazakh National Medical University named after S. D. Asfendiyarova
MD, PhD, Professor, Department of General Medical Practice No. 1

92 Tole Bi Str., Almaty 50012, Kazakhstan


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For citations:

Gromova O.A., Torshin I.Yu., Gabdulina G.K. COVID-19 pandemic: protective role of vitamin D. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(2):132-145. (In Russ.)

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