Prospects for the use of chondroitin sulfate and glucosamine sulfate with osteoarthritis associated with pathology of the kidneys and urinary system
Abstract
Introduction. Chondroitin sulfate (CS) and glucosamine sulfate (GS), widely used as chondroprotectors, can maintain the normal functioning of the urinary system but their effect has not been analyzed systematically.
Aim: to perform a systematic analysis of the possibilities of using CS and GS in patients with pathology of the kidneys and urinary system.
Materials and methods. Predictive analysis of 2,093 publications on the interactions of CS/GS with the functioning of the kidneys and other organs of the urinary system found at the request “(urinary OR bladder OR kidney) AND (glucosamine OR chondroitin)” by methods of the theory of topological data analysis.
Results. Disorders of cholesterol and glucosamine metabolism are characteristic of cystitis, glomerular nephritis, urinary tract infections (UTIs), urolithiasis, proteinuria, and formation of diabetic nephropathy. In addition to inhibiting the pro-inflammatory cascade NF-kB, CS/GS contribute to eliminating the deficiency of glycosaminoglycans in the pathology of urothelium, inhibit urolithiasis, inhibit the synthesis of pro-inflammatory nitric oxide NO in macrophages, and modulate O-glycosylation processes.
Conclusion. The results of fundamental and clinical studies show that subsidies of CS/GS substances of pharmacological quality per os and CS instillation in the bladder (in particular, in combination with hyaluronic acid) are the means of choice for patients suffering from osteoarthritis and diseases of the urinary system. Highly purified pharmacological CS substances are part of the preparation Chondroguard.
About the Authors
I. Yu. Torshin
Federal Research Center “Informatics and Management of the Russian Academy of Sciences”;
Moscow State University
Russian Federation
Russian Federation
Ivan Yu. Torshin – MD, PhD, Senior Researcher;
Scopus Author ID: 7003300274; RISIN SPIN-code: 1375-1114; Author ID: 54104; WOS ID: C-7683-2018.
4-2 Vavilova Str., Moscow 119333;
1 Leninskie gory, Moscow 119991
A. М. Lila
V.A. Nasonovа Research Institute of Rheumatology
Russian Federation
Russian Federation
Aleksandr M. Lila – MD, Dr Sci Med, Professor, Director
Scopus Autor ID: 6602550827; eLIBRARY ID: 367966; Researcher ID: W-3334-2017-7287-8555.
34A Kashirskoye Shosse, Moscow 115522
O. A. Limanova
Moscow State University;
Ivanovo State Medical Academy
Russian Federation
Russian Federation
Olga A. Limanova – MD, PhD, Associate Professor of the Department of Pharmacology
1 Leninskie gory, Moscow 119991;
8 Sheremetevsky prospekt, Ivanovo 153012
O. A. Gromova
Federal Research Center “Informatics and Management of the Russian Academy of Sciences”;
Moscow State University
Russian Federation
Russian Federation
Olga A. Gromova – MD, Dr Sci Med, Professor, Senior Researcher, Scientific Director; Leading Researcher, Center for Big Data Analysis
RISIN SPIN-code: 6317-9833; Author ID: 94901; Scopus Author ID: 7003589812; WOS ID: J-4946-2017
4-2 Vavilova Str., Moscow 119333;
1 Leninskie gory, Moscow 119991
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Torshin I.Yu., Lila A.М., Limanova O.A., Gromova O.A. Prospects for the use of chondroitin sulfate and glucosamine sulfate with osteoarthritis associated with pathology of the kidneys and urinary system. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(1):23-34. (In Russ.) https://doi.org/10.17749/2070-4909.2020.13.1.23-34
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