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Economic challenges of oncological diseases’ pharmacotherapy

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Oncological diseases rank high in the structure of population morbidity and mortality. They entail considerable direct and indirect economic costs. In the past decades, the cost of oncotherapy has increased significantly, which is largely conditioned by high prices of antitumor drugs, which on average increased by ten times in the past ten years. At the same time, many innovative medications have only minor advantages over cheaper old medications because they are registered based on the data on the achievement of the surrogate endpoint – extension of progression-free survival. The high cost of oncotherapy is associated with financial toxicity that affects negatively the patients’ quality of life, their adherence to treatment and consequently survival. To reduce the cost of oncotherapy, it is necessary to conduct pharma-economic analysis, the results of which can serve as the basis to negotiate price-cutting with the manufacturers, as well as to use high-quality generics and biosimilars as effective and safe as their originals, and to monitor effectiveness and safety of all antitumor drugs within the pharmacovigilance framework.

About the Authors

E. A. Ushkalova
Peoples’ Friendship University of Russia
Russian Federation

Elena A. Ushkalova – MD, Dr Sci Med, Professor, Department of General and Clinical Pharmacology

 Researcher ID: A-4765-2017. Scopus Author ID: 56633092200. RISIN SPIN-code: 7722-5802

S. K. Zyryanov
Peoples’ Friendship University of Russia; City Clinical Hospital No. 24 of the Moscow Department of Health
Russian Federation

Sergey K. Zyryanov – MD, Dr Sci Med, Professor & Head, Department of General and Clinical Pharmacology; Deputy Chief Medical Officer, Clinical Hospital No. 24

Researcher ID: D-8826-2012. RISIN SPIN-code: 2725-9981

I. A. Gopienko
Peoples’ Friendship University of Russia
Russian Federation

Irina A. Gopienko – Postgraduate student, Department of General and Clinical Pharmacology

RISIN SPIN-code: 8192-4441


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For citation:

Ushkalova E.A., Zyryanov S.K., Gopienko I.A. Economic challenges of oncological diseases’ pharmacotherapy. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2020;13(1):64-70. (In Russ.)

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