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COMPARATIVE COST-MINIMIZATION AND BUDGET-IMPACT ANALYSIS OF FIXED-DOSE INHALED CORTICOSTEROID / LONG-ACTING BETAAGONIST COMBINATIONS IN THE TREATMENT OF ASTHMA

https://doi.org/10.17749/2070-4909.2017.10.2.012-021

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Abstract

Comparative pharmacoeconomic analysis of fixed-dose combinations (FDC) vilanterol / fluticasone furoate vs budesonide / formoterol was needed to identify the preferable FDC for asthma management.

Study objective: to identify the preferable FDC of inhaled corticosteroid/ longacting beta agonist combinations (ICS/LABA) for the treatment of moderate or severe asthma in Russia. Materials and

Methods. Retrospective comparative pharmacoeconomic study; cost-minimization analysis and budget-impact analysis.

Results. The present analysis shows that the 12-month direct medical costs for the treatment of asthma using vilanterol / fluticasone furoate and budesonide / formoterol are 29,276 and 40,447 RUR per patient, respectively. The direct costs of treatment with vilanterol / fluticasone furoate are less than those for budesonide / formoterol by 28%. The annual health budget savings that result from replacing budesonide / formoterol by vilanterol / fluticasone furoate are 1,151,512,731 RUR per 100,000 patients.

Conclusion. The present results indicate that the vilanterol / fluticasone furoate FDC is preferable (more beneficial) as compared with the budesonide / formoterol FDC. 

About the Authors

N. L. Pogudina
Independent Research Company «Smart Choice»
Russian Federation

PhD, 

Otkrytoe shosse, 23/6, Moscow, 107143



E. G. Kosolapov
Independent Research Company «Smart Choice»
Russian Federation
Otkrytoe shosse, 23/6, Moscow, 107143


F. S. Kochenkov
Independent Research Company «Smart Choice»
Russian Federation

PhD, 

Otkrytoe shosse, 23/6, Moscow, 107143



A. V. Karaulov
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation

Acad. RAS, Prof., MD, Head of the Department of Clinical Immunology and Allergology,

ul. Trubetskaya, 8, str. 2, Moscow, 119048



N. L. Bondarenko
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation; Clinical Hospital № 85, FMBA of Russia
Russian Federation

PhD, Associate Professor of the Department of Clinical Immunology and Allergology;

Chief Physician, Kashirskoe shosse, d. 13G, Moscow, 115230



D. V. Blinov
N. I. Pirogov Russian National Research Medical University
Russian Federation

PhD, 

ul. Ostrovityanova, 1, Moscow, 117997



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For citation:


Pogudina N.L., Kosolapov E.G., Kochenkov F.S., Karaulov A.V., Bondarenko N.L., Blinov D.V. COMPARATIVE COST-MINIMIZATION AND BUDGET-IMPACT ANALYSIS OF FIXED-DOSE INHALED CORTICOSTEROID / LONG-ACTING BETAAGONIST COMBINATIONS IN THE TREATMENT OF ASTHMA. FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology. 2017;10(2):12-21. (In Russ.) https://doi.org/10.17749/2070-4909.2017.10.2.012-021

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