Background

farmaec

FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology

ФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология

2070-49092070-4933

IRBIS LLC

10.17749/2070-4909/farmakoekonomika.2023.187

farmaec-891

Research Article

REVIEW ARTICLES

ОБЗОРНЫЕ ПУБЛИКАЦИИ

Possibilities of using coenzyme Q10 for the treatment of diseases associated with mitochondrial dysfunction and chronic inflammation

Возможности применения коэнзима Q10 для лечения заболеваний, сопряженных с дисфункцией митохондрий и хроническим воспалением

https://orcid.org/0000-0002-7663-710X

Громова

О. А.

Gromova

O. A.

д.м.н., профессор, ведущий научный сотрудник ФИЦ «Информатика и управление» РАН

ул. Вавилова, д. 44, корп. 2, Москва 119333

Dr. Med. Sc., Professor, Leading Researcher, Federal Research Center “Computer Science and Control”, RAS

44 corp. 2 Vavilov Str., Moscow 119333

unesco.gromova@gmail.com

https://orcid.org/0000-0002-2659-7998

Торшин

И. Ю.

Torshin

I. Yu.

к.ф-м.н., к.х.н., старший научный сотрудник ФИЦ «Информатика и управление» РАН

ул. Вавилова, д. 44, корп. 2, Москва 119333

PhD (Phys. Math.), PhD (Chem.), Senior Researcher, Federal Research Center “Computer Science and Control”, RAS

44 corp. 2 Vavilov Str., Moscow 119333

https://orcid.org/0000-0001-7507-191X

Громов

А. Н.

Gromov

A. N.

инженер-исследователь ФИЦ «Информатика и управление» РАН

ул. Вавилова, д. 44, корп. 2, Москва 119333

Research Engineer, Federal Research Center “Computer Science and Control”, RAS

44 corp. 2 Vavilov Str., Moscow 119333

Федеральный исследовательский центр «Информатика и управление» Российской академии наукРоссияFederal Research Center “Computer Science and Control”, Russian Academy of SciencesRussian Federation

2023

09112023

163466480

2023

Громова О.А., Торшин И.Ю., Громов А.Н.

Gromova O.A., Torshin I.Y., Gromov A.N.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmacoeconomics.ru/jour/article/view/891

Background

Background. The enzymatic cofactor coenzyme Q10 (CoQ10) is involved in the synthesis of adenosine triphosphate in mitochondria. The CoQ10 biosynthesis declines when using statin drugs.

Objective

Objective: systematization of the impact of coenzyme Q10 on chronic, sluggish systemic inflammation leading to the development of atherosclerosis, liver and pancreas pathologies, and neurodegeneration.

Material and methods

Material and methods. Systematic computer analysis of 16,788 publications on CoQ10 found by the query “coenzyme Q10 OR ubiquinone” in PubMed/MEDLINE database of biomedical publications was carried out. Current methods of topological and metric data analysis developed at the scientific school of Academician of the Russian Academy of Sciences Yu.I. Zhuravlev were used.

Results

Results. CoQ10 is involved in the regulation of inflammation and exhibits lipid-lowering, hepatoprotective, nephroprotective, anti-asthenic, cardioprotective, and neuroprotective effects. CoQ10 favorably affects carbohydrate metabolism and a wide range of neurological diseases.

Conclusion

Conclusion. CoQ10 supplementation improves glycemic control in insulin resistance, kidney function, and is useful in the treatment of migraine and neurodegenerative pathologies (Parkinson’s disease, etc.).

Актуальность

Актуальность. Ферментативный кофактор коэнзим Q10 (англ. coenzyme Q10, CoQ10) участвует в синтезе аденозинтрифосфата в митохондриях. Биосинтез CoQ10 снижается на фоне использования статиновых препаратов.

Цель

Цель: систематизация сведений о воздействии СоQ10 на хроническое вялотекущее системное воспаление, приводящее к развитию атеросклероза, патологий печени, поджелудочной железы и нейродегенерации.

Материал и методы

Материал и методы. Проведен систематический компьютерный анализ 16 788 публикаций, найденных по запросу “coenzyme Q10 OR ubiquinone” в базе данных биомедицинских публикаций PubMed/MEDLINE. Использованы современные методы топологического и метрического анализа больших данных, разрабатываемые в научной школе академика РАН Ю.И. Журавлёва.

Результаты

Результаты. CoQ10 принимает участие в регуляции воспаления, проявляет гиполипидемический, гепатопротекторный, нефро- протекторный, антиастенический, кардиопротекторный и нейропротекторный эффекты. CoQ10 благоприятно влияет на углеводный обмен и широкий круг неврологических заболеваний.

Заключение

Заключение. Дотации CoQ10 улучшают гликемический контроль при инсулинорезистентности, функцию почек, полезны в терапии мигрени и нейродегенеративных патологий (болезнь Паркинсона и др.).

Коэнзим Q10CoQ10митохондриивоспалениеглюкозотолерантностьневрологические заболеванияфармакоинформатикаЛактофлорене ХолестеролLactoflorene Холестерол

Coenzyme Q10CoQ10mitochondriainflammationglucose toleranceneurological diseasespharmacoinformaticsLactoflorene Cholesterol

Работа выполнена при поддержке гранта Российского научного фонда (проект № 23-21-00154 «Разработка методов прогноза свойств фармакологических препаратов по их молекулярной структуре с помощью теории топологического анализа хемографов»), ФИЦ ИУ РАН.

The work was supported by a grant of the Russian Science Foundation (project No. 23-21-00154 “Development of methods for predicting the properties of pharmacological preparations based on their molecular structure using the theory of topological analysis of chemographs”), FRC “Computer Science and Control”, RAS.

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The authors declare that there are no conflicts of interest present.