farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLC10.17749/2070-4909/farmakoekonomika.2022.141farmaec-701Research ArticleREVIEW ARTICLESОБЗОРНЫЕ ПУБЛИКАЦИИEpigenetic aspects in rehabilitation of female cancer patientsЭпигенетические аспекты реабилитации онкогинекологических больныхhttps://orcid.org/0000-0002-7456-2386СолоповаА. Г.SolopovaA. G.

Солопова Антонина Григорьевна – д.м.н., профессор кафедры акушерства и гинекологии Клинического института детского здоровья им. Н.Ф. Филатова. WoS ResearcherID: Q-1385-2015; Scopus Author ID: 6505479504; РИНЦ SPIN-код: 5278-0465

ул. Трубецкая, д. 8/2, Москва 119048

Antonina G. Solopova – Dr. Med. Sc., Professor, Chair of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health. Scopus Author ID: 6505479504; WoS ResearcherID: Q-1385-2015; RSCI SPIN-code: 5278-0465

8/2 Trubetskaya Str., Moscow 119991

antoninasolopova@yandex.ruhttps://orcid.org/0000-0002-7663-710XБлиновД. В.BlinovD. V.

Блинов Дмитрий Владиславович – к.м.н., руководитель по научным и медицинским вопросам; врач-невролог; преподаватель кафедры неврологии, психиатрии и наркологии. WoS ResearcherID: J-4946-2017; Scopus Author ID: 7003589812; РИНЦ SPIN-код: 6317-9833

ул. Садовая-Триумфальная, д. 4/10, Москва 1270061-е Успенское ш., д. 111, Московская обл., Одинцовский р-н, Лапино 143081ул. 2-я Брестская, д. 5, стр. 1-1а, Москва 123056

Dmitry V. Blinov – MD, PhD, MBA, Head of Medical and Scientific Affairs; Neurologist; Faculty Member, Chair of Neurology, Psychiatry and Narcology. WoS ResearcherID: J-4946-2017; Scopus Author ID: 7003589812; RSCI SPIN-code: 6317-9833

4/10 Sadovaya-Triumfalnaya Str., Moscow 127006111 1st Uspenskoye Hwy, Moscow Region, Odintsovo District, Lapino 1430815 bldg 1-1a 2nd Brestskaya Str., Moscow 123056

https://orcid.org/0000-0002-1893-7198ДемьяновС. В.DemyanovS. V.

Демьянов Семен Валерьевич – студент 5-го курса

ул. Трубецкая, д. 8/2, Москва 119048

Semen V. Demyanov – 5th Year Student

8/2 Trubetskaya Str., Moscow 119991

https://orcid.org/0000-0003-1584-4604ДемьяновГ. В.DemyanovG. V.

Демьянов Глеб Валерьевич – студент 5-го курса

ул. Трубецкая, д. 8/2, Москва 119048

Gleb V. Demyanov – 5th Year Student

8/2 Trubetskaya Str., Moscow 119991

https://orcid.org/0000-0001-9964-5199АчкасовЕ. Е.AchkasovE. E.

Ачкасов Евгений Евгеньевич – д.м.н., профессор, заведующий кафедрой спортивной медицины и медицинской реабилитации Института клинической медицины. РИНЦ SPIN-код: 5291-0906

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Evgeniy E. Achkasov – Dr. Med. Sc., Professor, Head of Department of Sports Medicine and Rehabilitation. RSCI SPIN-code: 5291-0906

8/2 Trubetskaya Str., Moscow 119991

https://orcid.org/0000-0001-8660-7951ВласинаА. Ю.VlasinaA. Yu.

Власина Анастасия Юрьевна – аспирант кафедры акушерства и гинекологии Клинического института детского здоровья им. Н.Ф. Филатова. WoS ResearcherID: AAF-3130-2020; Scopus Author ID: 1016902; РИНЦ SPIN-код: 1496-6522

ул. Трубецкая, д. 8/2, Москва 119048

Anastasia Yu. Vlasina – Postgraduate, Chair of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health. WoS ResearcherID: AAF-3130-2020; Scopus Author ID: 1016902; RSCI SPIN-code: 1496-6522

8/2 Trubetskaya Str., Moscow 119991

https://orcid.org/0000-0002-5083-6581СанджиеваЛ. Н.SandzhievaL. N.

Санджиева Лидия Николаевна – аспирант кафедры акушерства и гинекологии Клинического института детского здоровья им. Н.Ф. Филатова. РИНЦ SPIN-код: 7228-3726

ул. Трубецкая, д. 8/2, Москва 119048

Lidiya N. Sandzhieva – Postgraduate, Chair of Obstetrics and Gynecology, Filatov Clinical Institute of Children's Health. RSCI SPIN-code: 7228-3726

8/2 Trubetskaya Str., Moscow 119991

https://orcid.org/0000-0002-3509-9501АмпилоговаД. М.AmpilogovaD. M.

Ампилогова Диана Михайловна – клинический ординатор кафедры акушерства и гинекологии Института клинической медицины им. Н.В. Склифосовского

ул. Трубецкая, д. 8/2, Москва 119048

Diana M. Ampilogova – MD, Clinical Resident, Chair of Obstetrics and Gynecology, Sklifosovsky Institute of Clinical Medicine

8/2 Trubetskaya Str., Moscow 119991

Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет им. И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияSechenov UniversityRussian FederationИнститут Превентивной и Социальной Медицины; Клинический госпиталь «Лапино» группы компаний «Мать и Дитя»; Автономная некоммерческая организация дополнительного профессионального образования «Московский медико-социальный институт им. Ф.П. Гааза»РоссияInstitute for Preventive and Social Medicine; Lapino Clinical Hospital, Medical Group “Mother and Child”; Moscow Haass Medical Social InstituteRussian Federation202228072022152294303Copyright © Solopova A.G., Blinov D.V., Demyanov S.V., Demyanov G.V., Achkasov E.E., Vlasina A.Y., Sandzhieva L.N., Ampilogova D.M., 20222022Солопова А.Г., Блинов Д.В., Демьянов С.В., Демьянов Г.В., Ачкасов Е.Е., Власина А.Ю., Санджиева Л.Н., Ампилогова Д.М.Solopova A.G., Blinov D.V., Demyanov S.V., Demyanov G.V., Achkasov E.E., Vlasina A.Y., Sandzhieva L.N., Ampilogova D.M.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/701

The influence of epigenetic processes on the development of malignant diseases, including gynaecological cancers, is now beyond doubt. DNA methylation, histone modification and post-transcriptional regulation by microRNAs lead to changes in the activity of various genes, contributing to female genital cancers (cervix, endometrium, ovarian). It should be noted that disruptions in gene expression do not only occur in malignant cells, but also in the tumour microenvironment, resulting in disease progression and relapse. However, “epigenetic markers” of carcinogenesis can be useful in the treatment and rehabilitation of patients, making a personalized approach possible.

На сегодняшний день влияние эпигенетических процессов на развитие злокачественных заболеваний, включая онкогинекологические, не вызывает сомнений. Метилирование ДНК, модификация гистонов и посттранскрипционная регуляция при помощи микроРНК приводят к изменению активности различных генов, способствуя возникновению рака женских половых органов (шейки матки, эндометрия, яичников). Следует отметить, что нарушения в экспрессии генов появляются не только в злокачественных клетках, но и в микроокружении опухоли, обусловливая прогрессирование и рецидив заболевания. Однако «эпигенетические метки» канцерогенеза могут быть полезными в лечении и реабилитации пациенток, делая возможным применение персонифицированного подхода.

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The authors declare that there are no conflicts of interest present.