farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLC10.17749/2070-4909/farmakoekonomika.2021.112farmaec-630Research ArticleREVIEW ARTICLESОБЗОРНЫЕ ПУБЛИКАЦИИHepatoprotective effects of chondroitin sulfate and glucosamine sulfateГепатопротекторные эффекты хондроитина сульфата и глюкозамина сульфатаhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич – к.ф-м.н., к.х.н., старший научный сотрудник

WoS ResearcherID: C-7683-2018

Scopus Author ID: 7003300274

РИНЦ SPIN-код: 1375-1114 

ул. Вавилова, д. 4, Москва 119333

Ivan Yu. Torshin – PhD (Phys. Math.), PhD (Chem.), Senior Researcher

WoS ResearcherID: C-7683-2018

Scopus Author ID: 7003300274

RSCI SPIN-code: 1375-1114 

4 Vavilov Str., Moscow 119333

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

Лила Александр Михайлович – д.м.н., профессор, директор

WoS ResearcherID: W-3334-2017

Scopus Author ID: 6602550827

РИНЦ SPIN-код: 7287-8555 

Каширское ш., д. 34А, Москва 115522

Aleksandr M. Lila – Dr. Med. Sc., Professor, Director

WoS ResearcherID: W-3334-2017

Scopus Author ID: 6602550827

RSCI SPIN-code: 7287-8555 

34А Kashirskoye Hwy, Moscow 115522

https://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна – д.м.н., профессор, научный руководитель

WoS ResearcherID: J-4946-2017

Scopus Author ID: 7003589812

РИНЦ SPIN-код: 6317-9833 

ул. Вавилова, д. 4, Москва 119333

Olga A. Gromova – Dr. Med. Sc., Professor, Research Supervisor

WoS ResearcherID: J-4946-2017

Scopus Author ID: 7003589812

RSCI SPIN-code: 6317-9833 

4 Vavilov Str., Moscow 119333

unesco.gromova@gmail.comФедеральный исследовательский центр «Информатика и управление» Российской академии наукРоссияFederal Research Center “Informatics and Management”, Russian Academy of SciencesRussian FederationФедеральное государственное бюджетное научное учреждение «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияNasonov Research Institute of RheumatologyRussian Federation202115012022144537547Copyright © Torshin I.Y., Lila A.M., Gromova O.A., 20222022Торшин И.Ю., Лила А.М., Громова О.А.Torshin I.Y., Lila A.M., Gromova O.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/630

Background. Long-term use of chondroprotective agents – chondroitin sulfate (CS) and glucosamine sulfate (GS) in the treatment of osteoarthritis puts forward increased requirements for the safety of drugs, primarily in terms of effects on the liver and kidneys.Objective: systematization of data on the effect of chondroprotectors on liver structure and functions.Material and methods. Using the methods of the theory of topological text analysis, an intellectual analysis of 2319 publications on fundamental and clinical studies of the relationship of CS and GS with liver function was carried out. The search was performed by a key query “(chondroitine OR glucosamine) AND (liver OR hepatic OR hepatocy*)” in the PubMed/MEDLINE database.Results. The systematic analysis indicated a pronounced hepatoprotective effect of CS and GS pharmaceutical substances with a high degree of purification from inorganic and organic impurities. By regulating inflammation processes, lymphocyte function, fat and carbohydrate metabolism in the liver, standardized forms of CS and GS have a beneficial effect on fat metabolism, reduce chronic inflammation in the liver, exhibit antitumor and pronounced hepatoprotective effects on various models of liver intoxication.Conclusion. The results of this analysis allow us to assert the high safety of drugs based on pharmaceutical standardized forms of CS and GS in terms of liver function.

Актуальность. Долговременное применение хондропротекторных средств хондроитина сульфата (ХС) и глюкозамина сульфата (ГС) в терапии остеоартрита выдвигает повышенные требования к безопасности препаратов – прежде всего, с точки зрения воздействия на печень и почки.Цель: систематизация информации о воздействиях хондропротекторов на структуру и функцию печени.Материал и методы. Методами теории топологического анализа текстов проведен интеллектуальный анализ 2319 научных статей по фундаментальным и клиническим исследованиям взаимосвязей ХС и ГС с функцией печени. Поиск статей осуществляли по ключевому запросу “(chondroitine OR glucosamine) AND (liver OR hepatic OR hepatocy*)” в базе биомедицинских публикаций Pubmed/MEDLINE.Результаты. Систематический анализ указывает на выраженный гепатопротекторный эффект фармацевтических субстанций ХС и ГС с высокой степенью очистки от неорганических и органических примесей. Регулируя процессы воспаления, функцию лимфоцитов, обмен жиров и углеводов в печени, стандартизированные формы ХС и ГС благоприятно влияют на обмен жиров, снижают хроническое воспаление в печени, проявляют противоопухолевые и выраженные гепатопротекторные эффекты на различных моделях интоксикации печени.Заключение. Результаты анализа позволяют утверждать, что препараты на основе фармацевтических стандартизированных форм ХС и ГС обладают высокой степенью безопасности с точки зрения их воздействия на функции печени.

гепатопротекцияэффективность и безопасность фармакотерапиихондроитина сульфатглюкозамина сульфаттопологический анализ данныхhepatoprotectionefficacy and safety of pharmacotherapychondroitin sulfateglucosamine sulfatetopological data analysisРабота выполнена по гранту Российского научного фонда (проект № 20-12-00175) в Ивановском государственном химико-технологическом университете.This work was financially supported by the grant of the Russian Science Foundation (No. 20-12-00175) in Ivanovo State University of Chemistry and Technology.ReferencesBlüher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019; 15 (5): 288–98. https://doi.org/10.1038/s41574-019-0176-8.Blüher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019; 15 (5): 288–98. https://doi.org/10.1038/s41574-019- 0176-8.Reginato A.M., Riera H., Vera M., et al. Osteoarthritis in Latin America: study of demographic and clinical characteristics in 3040 patients. 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The authors declare that there are no conflicts of interest present.