farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLC10.17749/2070-4909/farmakoekonomika.2021.090farmaec-624Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ ПУБЛИКАЦИИAnalysis of the consumption volumes of antithrombotic drugs used for pharmacotherapy of atrial fibrillation in Saratov RegionАнализ объемов потребления антитромботических препаратов, применяемых для фармакотерапии фибрилляции предсердий в Саратовской областиhttps://orcid.org/0000-0003-2220-7726СоколовА. В.SokolovА. V.

Соколов Алексей Владимирович – ассистент кафедры фармакологии

РИНЦ SPIN-код: 7822-8424 

ул. Большая Казачья, д.112, Саратов 410012

Alexey V. Sokolov – Assistant Professor, Chair of Pharmacology

RSCI SPIN-code: 7822-8424 

112 Bolshaya Kazachya Str., Saratov 410012

sokolovalexsej@mail.ruhttps://orcid.org/0000-0003-3107-7636РешетькоО. В.Reshet’koО. V.

Решетько Ольга Вилоровна – д.м.н., профессор, заведующая кафедрой фармакологии

WoS ResearcherID: I-7011-2013

Scopus Author ID: 36141145800

РИНЦ SPIN-код: 7569-7915 

ул. Большая Казачья, д.112, Саратов 410012

Olga V. Reshet’ko – Dr. Med. Sc., Professor, Chief of Chair of Pharmacology

WoS ResearcherID: I-7011-2013

Scopus Author ID: 36141145800

RSCI SPIN-code: 7569-7915 

112 Bolshaya Kazachya Str., Saratov 410012

Федеральное государственное бюджетное образовательное учреждение высшего образования «Саратовский государственный медицинский университет им. В.И. Разумовского» Министерства здравоохранения Российской ФедерацииРоссияSaratov State Medical University named after V.I. RazumovskyRussian Federation202115012022144462467Copyright © Sokolov А.V., Reshet’ko О.V., 20222022Соколов А.В., Решетько О.В.Sokolov А.V., Reshet’ko О.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/624

Objective: To study the evolution of consumption of antithrombotic drugs used for the treatment of atrial fibrillation (AF) at the outpatient stage in the Saratov Region using the ATC/DDD (Anatomical Therapeutic Chemical Classification / Defined Daily Doses) and drug utilization 90% (DU90%) analysis.Material and methods. We analyzed the outpatient stage of treatment using the data reflected in 511 case histories of AF patients hospitalized in specialized cardiology departments of the Saratov Region in 2011–2018. The study of the consumption volumes of antithrombotic drugs was carried out using the ATC/DDD- and DU90%-analysis methodology. The consumption of drugs with proven efficacy in AF was expressed as the number of daily doses (NDDD) per 1000 AF patients per day.Results. In 2011, the number of prescribed DDD of oral anticoagulants (OACs) was 5.29 NDDD per 1000 AF patients per day, and all of them were represented by warfarin; in 2018, this indicator increased up to 277.51 NDDD per 1000 AF patients per day, of which direct OACs amounted to 237.06. The consumption of antiplatelet agents remained at a high level, and in 2018, was 582.53 NDDD per 1000 AF patients per day. Acetylsalicylic acid was included in the group of drugs accounting for 90% of all antithrombotic drugs at the outpatient stage – 99.02% in 2011, 93.08% in 2012, 58.55% in 2016, 60.27% in 2017, and 46.66% in 2018.Conclusion. The consumption volumes of OACs used at the outpatient stage of treatment of AF in the Saratov Region increased significantly in the period from 2011 to 2018, mainly due to direct OACs. At the same time, the consumption volumes of antiplatelet agents remained at a high level.

Цель: изучить объемы потребления антитромботических препаратов, используемых для терапии фибрилляции предсердий (ФП), применяя методологии анализа установленных суточных доз (англ. ATC/DDD – Anatomical Therapeutic Chemical Classification / Defined Daily Doses) и 90% потребления лекарственного средства (англ. Drug Utilization 90%, DU90%) на амбулаторном этапе лечения в Саратовской обл.Материал и методы. Проведено исследование амбулаторного этапа лечения ФП на основании данных, отраженных в 511 историях болезней пациентов, госпитализированных в специализированные кардиологические отделения Саратовской обл. в 2011–2018 гг. Проанализированы объемы потребления антитромботических лекарственных средств с использованием методологий ATC/DDDи DU90%-анализа. Объемы потребления препаратов с доказанной эффективностью при ФП выражали как количество установленных суточных доз (NDDD) на 1000 больных с ФП в день.Результаты. В 2011 г. объемы потребления оральных антикоагулянтов (ОАК) составляли 5,29 NDDD на 1000 пациентов с ФП в день, и все они приходились на антагонист витамина К варфарин. В 2018 г. этот показатель увеличился до 277,51 NDDD на 1000 больных с ФП в день, из них 237,06 пришлось на прямые ОАК. Объемы потребления антиагрегантов остались на высоком уровне и в 2018 г. составляли 582,53 NDDD на 1000 пациентов с ФП в день. Ацетилсалициловая кислота вошла в группу препаратов, составляющих 90% всех потребляемых антитромботических препаратов при ФП на амбулаторном этапе в 2011 г. (99,02%) и 2012 г. (93,08%). В 2016 г. на нее приходилось 58,55%, в 2017 г. – 60,27%, в 2018 г. – 46,66%.Заключение. В период с 2011 г. по 2018 г. объемы потребления ОАК на амбулаторном этапе лечения ФП в Саратовской обл. значительно выросли, преимущественно за счет прямых ОАК. При этом объемы потребления антиагрегантов остались на высоком уровне.

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The authors declare that there are no conflicts of interest present.