farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLCfarmaec-57Research ArticleEconomic ReviewЭкономический обзорEVALUATION OF SAFETY OF DRUG THERAPY IN CLINICAL PRACTICEОценка безопасности лекарственной терапии в клинической практике Костылева М.Н.1,2, Белоусов Ю.Б.2, Грацианская А.Н.1,2,КостылеваМ. Н.KostylevaM. N.БелоусовЮ. Б.BelousovYu. B.ГрацианскаяА. Н.GratsianskayaA. N.ПостниковС. С.PostnikovS. S.ФГБУ «Российская детская клиническая больница» Минздрава РФ, Москва; ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава РФ, МоскваРоссияRussian Children's Clinical Hospital, Ministry of Health of the Russian Federation, Moscow; The Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation, MoscowRussian FederationГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава РФ, МоскваРоссияThe Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation, MoscowRussian Federation201422032015712732Copyright © Kostyleva M.N., Belousov Y.B., Gratsianskaya A.N., Postnikov S.S., 20152015Костылева М.Н., Белоусов Ю.Б., Грацианская А.Н., Постников С.С.Kostyleva M.N., Belousov Y.B., Gratsianskaya A.N., Postnikov S.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/57

the present review is devoted to an actual problem of safety of pharmacotherapy in clinical practice; the particular attention is paid to the state of this problem in pediatrics. Information about pharmacovigilance is proposed; criteria of definition, methods of collecting (their advantages and limitations), account and analysis of the adverse reactions of drugs in post-marketing period are described. The off label use of drugs in children and a role of clinical pharmacologist in the adverse reactions of drugs monitoring in a hospital is discussed.

настоящий обзор посвящен актуальной проблеме безопасности фармакотерапии в клинической практике, отдельное внимание уделено состоянию проблемы в педиатрии. Предлагаются сведения о фармаконадзоре: описаны критерии определения, методы сбора (их преимущества и недостатки), учета и анализа нежелательных явлений лекарств на пострегистрационном этапе. Обсуждается проблема off label назначений лекарств у детей и роль врача-клинического фармаколога в организации мониторинга нежелательных явлений в условиях стационара.

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The authors declare that there are no conflicts of interest present.