References

farmaec

FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology

ФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология

2070-49092070-4933

IRBIS LLC

10.17749/2070-4909/farmakoekonomika.2021.105

farmaec-555

Research Article

REVIEW ARTICLES

ОБЗОРНЫЕ ПУБЛИКАЦИИ

Modern achievements in pharmacotherapy of osteoarthritis based on endo- and phenotyping

Современные достижения в фармакотерапии остеоартрита на основе эндо- и фенотипирования

https://orcid.org/0000-0002-5933-5732

Сарвилина

И. В.

Sarvilina

I. V.

Сарвилина Ирина Владиславовна – д.м.н., клинический фармаколог, главный врач

РИНЦ SPIN-код: 7308-6756

ул. Социалистическая, д. 74, Ростов-на-Дону 344002, Россия

Irina V. Sarvilina – Dr. Med. Sc., Clinical Pharmacologist, Chief Physician

RSCI SPIN-code: 7308-6756

74 Sotsialisticheskaya, Rostov-on-Don 344002, Russia

isarvilina@mail.ru

https://orcid.org/0000-0003-3726-0730

Шавловская

О. А.

Shavlovskaya

O. A.

Шавловская Ольга Александровна – д.м.н., профессор кафедры организации медицинской реабилитации и санаторно-курортного лечения

WoS ResearcherID: V-4470-2018; Scopus Author ID: 15124744300; РИНЦ SPIN-код: 5300-4282

Фурманный пер., д. 8/2, Москва 105062, Россия

Olga А. Shavlovskaya – Dr. Med. Sc., Professor, Chair of Organization of Medical Rehabilitation and Sanatorium-Resort Treatment

WoS ResearcherID: V-4470-2018; Scopus Author ID: 15124744300; RSCI SPIN-code: 5300-4282

8/2 Furmannyy Al., Moscow 105062, Russia

https://orcid.org/0000-0002-7663-710X

Громова

О. А.

Gromova

O. A.

Громова Ольга Алексеевна – д.м.н., профессор, научный руководитель; ведущий научный сотрудник

Scopus Author ID: 7003589812; WoS ResearcherID: J-4946-2017;РИНЦ SPIN-код: 6317-9833

ул. Вавилова, д. 4, Москва 2119333, Россия

Ленинские Горы, д. 1, Москва 119991, Россия

Olga A. Gromova – Dr. Med. Sc., Professor, Research Supervisor; Leading Researcher

Scopus Author ID: 7003589812; WoS ResearcherID: J-4946-2017; RSCI SPIN-code: 6317-9833

4 Vavilov Str., Moscow 2119333, Russia

1 Leninskie Gory, Moscow 119991, Russia

https://orcid.org/0000-0002-6253-621X

Наумов

А. В.

Naumov

A. V.

Наумов Антон Вячеславович – д.м.н., профессор кафедры болезней старения

РИНЦ SPIN-код: 4763-9738

ул. 1-я Леонова, д. 16, Москва 129226, Россия

Anton V. Naumov – Dr. Med. Sc., Professor, Chair of Diseases of Aging

16 Pervaya Leonov Str., Moscow 129226, Russia

https://orcid.org/0000-0001-9634-346X

Шаров

М. Н.

Sharov

M. N.

Шаров Михаил Николаевич – д.м.н., профессор кафедры нервных болезней стоматологического факультета; руководитель неврологического отделения

Scopus Author ID: 57212167091; РИНЦ SPIN-код: 8506-6900

ул. Делегатская, д. 20, стр.1, Москва 127473, Россия

ул. Вучетича, д. 21, Москва 127206, Россия

Mikhail N. Sharov – Dr. Med. Sc., Professor, Chair of Nervous Diseases, Faculty of Dentistry; Head

Scopus Author ID: 57212167091; RSCI SPIN-code: 8506-6900

10 bld. 2 Delegatskaya Str., Moscow 127473, Russia

21 Vuchetich Str., Moscow 127206, Russia

https://orcid.org/0000-0003-4454-7174

Прокофьева

Ю. С.

Prokofyeva

Yu. S.

Прокофьева Юлия Сергеевна – аспирант кафедры нервных болезней стоматологического факультета

Scopus Author ID: 57216579623; РИНЦ SPIN-код: 8789-3644

ул. Делегатская, д. 20, стр.1, Москва 127473, Россия

Yulia S. Prokofyeva – Postgraduate, Chair of Nervous Diseases, Faculty of Dentistry

Scopus Author ID: 57216579623; RSCI SPIN-code: 8789-3644

10 bld. 2 Delegatskaya Str., Moscow 127473, Russia

Общество с ограниченной ответственностью «Медицинский центр «Новомедицина»РоссияMedical Centre “Novomeditsina”Russian Federation

Автономная некоммерческая организация высшего образования «Международный университет восстановительной медицины»РоссияInternational University of Restorative MedicineRussian Federation

Институт фармакоинформатики Федерального исследовательского центра «Информатика и управление» Российской академии наук; Центр хранения и анализа больших данных Федерального государственного бюджетного образовательного учреждения высшего образования «Московский государственный университет им. М.В. Ломоносова»РоссияInstitute of Pharmacoinformatics, Federal Research Center “Informatics and Management”, Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State UniversityRussian Federation

Федеральное государственное автономное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Министерства здравоохранения Российской ФедерацииРоссияPirogov Russian National Research Medical UniversityRussian Federation

Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Министерства здравоохранения Российской Федерации; Государственное бюджетное учреждение здравоохранения г. Москвы «Городская клиническая больница им. С.И. Спасокукоцкого» Департамента здравоохранения г. МосквыРоссияYevdokimov Moscow State University of Medicine and Dentistry; Spasokukotskiy City Clinical HospitalRussian Federation

Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Министерства здравоохранения Российской ФедерацииРоссияYevdokimov Moscow State University of Medicine and DentistryRussian Federation

2021

08102021

143379406

2021

Сарвилина И.В., Шавловская О.А., Громова О.А., Наумов А.В., Шаров М.Н., Прокофьева Ю.С.

Sarvilina I.V., Shavlovskaya O.A., Gromova O.A., Naumov A.V., Sharov M.N., Prokofyeva Y.S.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmacoeconomics.ru/jour/article/view/555

The review of medical literature is devoted to modern data in the field of diagnosis and treatment of osteoarthritis using endo- and phenotyping. It includes the latest data on the epidemiology of osteoarthritis of different localizations, modern definitions and classifications of osteoarthritis endotypes and phenotypes, pathobiochemical patterns and pathomorphological parallels of disease phenotypes, new methodological approaches to the phenotyping of osteoarthritis (prognostic, prescriptive phenotyping, alternative methods), as well as modern advances in pharmacotherapy of the disease based on data from selected randomized controlled trials and meta-analyzes.

Обзор медицинской литературы посвящен современным данным в области диагностики и терапии остеоартрита с помощью эндои фенотипирования. Рассмотрены последние данные по эпидемиологии остеоартрита разных локализаций, современные определения и классификации эндотипов и фенотипов остеоартрита, патобиохимические закономерности и патоморфологические параллели фенотипов заболевания, новые методологические подходы к фенотипированию остеоартрита (прогностическое, прескриптивное фенотипирование, альтернативные методы), а также современные достижения в области фармакотерапии заболевания, основанные на данных отдельных рандомизированных клинических исследований и метаанализов.

Остеоартритэндотипированиефенотипированиефармакотерапия остеоартрита

Osteoarthritisendotypingphenotypingpharmacotherapy of osteoarthritis

Статья подготовлена при поддержке ЗАО «ФармФирма «Сотекс», что не повлияло на структуру исследования, анализ и интерпретацию данных, а также на принятие решения о публикации полученных результатов

The article was prepared with the financial support of Sotex PharmFirm, which did not affect the structure of the study, the data analysis and interpretation, as well as the decision to publish the results

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The authors declare that there are no conflicts of interest present.