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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">farmaec</journal-id><journal-title-group><journal-title xml:lang="en">FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology</journal-title><trans-title-group xml:lang="ru"><trans-title>ФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2070-4909</issn><issn pub-type="epub">2070-4933</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2070-4909/farmakoekonomika.2021.086</article-id><article-id custom-type="elpub" pub-id-type="custom">farmaec-550</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ ПУБЛИКАЦИИ</subject></subj-group></article-categories><title-group><article-title>Pharmacoeconomic aspects of COVID-19 treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Фармакоэкономические аспекты лечения COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5868-8870</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рогова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rogova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рогова Ирина Вячеславовна – начальник отдела</p><p>РИНЦ SPIN-код: 3403-1923</p><p>ул. Делегатская, д. 20/1, Москва 127473, Россия</p></bio><bio xml:lang="en"><p>Irina V. Rogova – Head of Department</p><p>RSCI SPIN-code: 3403-1923</p><p>20/1 Delegatskaya Str., Moscow 127473, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6831-9486</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жидкова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhidkova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жидкова Елена Анатольевна – к.м.н., преподаватель; руководитель</p><p>РИНЦ SPIN-код: 5915-7535</p><p>ул. Делегатская, д. 20/1, Москва 127473, Россия</p><p>ул. Малая Грузинская, д. 52а, Москва 123557, Россия</p></bio><bio xml:lang="en"><p>Elena A. Zhidkova – MD, PhD, Tutor; Head</p><p>20/1 Delegatskaya Str., Moscow 127473, Russia</p><p>52а Malaya Gruzinskaya Str., Moscow 123557, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6899-9012</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Popova</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попова Инга Александровна – к.м.н., докторант</p><p>РИНЦ SPIN-код: 7619-7822</p><p>ул. Делегатская, д. 20/1, Москва 127473, Россия</p></bio><bio xml:lang="en"><p>Inga A. Popova – MD, PhD, Doctoral Student</p><p>RSCI SPIN-code: 7619-7822</p><p>20/1 Delegatskaya Str., Moscow 127473, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7923-9916</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заборовский</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaborovskiy</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заборовский Андрей Владимирович – д.м.н., доцент, заведующий кафедрой</p><p>WoS ResearcherID: Y-3653-2018; РИНЦ SPIN-код: 9592-2405</p><p>ул. Делегатская, д. 20/1, Москва 127473, Россия</p></bio><bio xml:lang="en"><p>Andrey V. Zaborovskiy – Dr. Med. Sc., Associate Professor, Chief of Chair</p><p>WoS ResearcherID: Y-3653-2018; RSCI SPIN-code: 9592-2405</p><p>20/1 Delegatskaya Str., Moscow 127473, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7603-6064</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуревич</surname><given-names>К. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurevich</surname><given-names>K. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гуревич Константин Георгиевич – д.м.н., профессор, заведующий кафедрой</p><p>WoS ResearcherID: C-2071-2017; Scopus Author ID: 55197151600; РИНЦ SPIN-код: 4344-3045</p><p>ул. Делегатская, д. 20/1, Москва 127473, Россия</p></bio><bio xml:lang="en"><p>Konstantin G. Gurevich – Dr. Med. Sc., Professor, Chief of Chair</p><p>WoS ResearcherID: C-2071-2017; Scopus Author ID: 55197151600; RSCI SPIN-code: 4344-3045</p><p>20/1 Delegatskaya Str., Moscow 127473, Russia</p></bio><email xlink:type="simple">kgurevich@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Yevdokimov Moscow State University of Medicine and Dentistry<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Министерства здравоохранения Российской Федерации; Центральная дирекция здравоохранения – филиал Открытого акционерного общества «Российские железные дороги»<country>Россия</country></aff><aff xml:lang="en">Yevdokimov Moscow State University of Medicine and Dentistry; Central Directorate of Healthcare – branch of Russian Railways JSC<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>07</day><month>10</month><year>2021</year></pub-date><volume>14</volume><issue>3</issue><fpage>357</fpage><lpage>364</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Rogova I.V., Zhidkova E.A., Popova I.A., Zaborovskiy A.V., Gurevich K.G., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Рогова И.В., Жидкова Е.А., Попова И.А., Заборовский А.В., Гуревич К.Г.</copyright-holder><copyright-holder xml:lang="en">Rogova I.V., Zhidkova E.A., Popova I.A., Zaborovskiy A.V., Gurevich K.G.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmacoeconomics.ru/jour/article/view/550">https://www.pharmacoeconomics.ru/jour/article/view/550</self-uri><abstract><p>The article provides an overview of global trends in various treatment approaches for COVID-19 in terms of pharmacoeconomic effectiveness. Different strategies for managing patients with the new coronavirus infection, separate groups of drugs are considered. The current clinical trials for COVID-19, the main directions, problems and challenges facing the healthcare system are discussed in detail. The aspects of the economic efficiency of various measures to prevent the spread of COVID-19 are presented. A thorough study of the pharmacoeconomic features of the new coronavirus infection will allow to develop effective standards for planning the process of supply for medical organizations in the pandemic.</p></abstract><trans-abstract xml:lang="ru"><p>В статье предложен обзор мировых тенденций различных лечебных подходов при COVID-19 с точки зрения фармакоэкономической эффективности. Рассматриваются различные стратегии ведения пациентов с новой коронавирусной инфекцией, отдельные группы лекарств. Подробно представлены текущие клинические исследования при COVID-19, основные направления, проблемы и задачи, стоящие перед системой здравоохранения. Обсуждаются аспекты экономической эффективности различных мер профилактики распространения COVID-19. Тщательное изучение фармакоэкономических особенностей новой коронавирусной инфекции позволит разработать эффективные стандарты по планированию процесса обеспечения медицинских организаций в условиях пандемии.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Фармакоэкономическая эффективность</kwd><kwd>пандемия</kwd><kwd>COVID-19</kwd><kwd>здравоохранение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Pharmacoeconomical efficiency</kwd><kwd>pandemic</kwd><kwd>COVID-19</kwd><kwd>healthcare</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dong E., Du H., Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020; 20 (5): 533–4. https://doi.org/10.1016/S1473-3099(20)30120-1.</mixed-citation><mixed-citation xml:lang="en">Dong E., Du H., Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020; 20 (5): 533–4. https://doi.org/10.1016/S1473-3099(20)30120-1.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Leonardi Vinci D., Polidori C., Polidori P. The healthcare and pharmaceutical vulnerability emerging from the new coronavirus outbreak. Eur J Hosp Pharm. 2020; 27 (3): 129–30. https://doi.org/10.1136/ejhpharm-2020-00227.</mixed-citation><mixed-citation xml:lang="en">Leonardi Vinci D., Polidori C., Polidori P. The healthcare and pharmaceutical vulnerability emerging from the new coronavirus outbreak. Eur J Hosp Pharm. 2020; 27 (3): 129–30. https://doi.org/10.1136/ejhpharm-2020-00227.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Перхов В.И., Песенникова Е.В. Особенности реакции систем здравоохранения отдельных стран на предсказанную пандемию COVID 19. Медицина и организация здравоохранения. 2020; 5 (3): 4–12.</mixed-citation><mixed-citation xml:lang="en">Perkhov V.I., Pesennikova E.V. Variety of forms of reaction of health care systems of particular countries to the predicted COVID-19 pandemic. Medicine and Health Care Organization. 2020; 5 (3): 4–12 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Pan W., Huang G., Shi Y., et al. COVID-19: short-term influence on China's economy considering different scenarios. Glob Chall. 2020; 5 (3): 2000090. https://doi.org/10.1002/gch2.202000090.</mixed-citation><mixed-citation xml:lang="en">Pan W., Huang G., Shi Y., et al. COVID-19: short-term influence on China's economy considering different scenarios. Glob Chall. 2020; 5 (3): 2000090. https://doi.org/10.1002/gch2.202000090.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Соколов Е.В., Костырин Е.В. Расходы и убытки государства и граждан России в борьбе с COVID-19 и необходимость возврата к нормальной жизни. Экономика и управление: проблемы, решения. 2020; 1 (7): 65–76.</mixed-citation><mixed-citation xml:lang="en">Sokolov E.V., Kostyrin E.V. Expenses and losses of the state and russian citizens to fight COVID-19 and the need to return to normal life. Economics and Management: Problems, Solutions. 2020; 1 (7): 65–76 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Jin H., Wang H., Li X., et al. Economic burden of COVID-19, China, January-March, 2020: a cost-of-illness study. Bull World Health Organ. 2021; 99 (2): 112–24. https://doi.org/10.2471/BLT.20.267112.</mixed-citation><mixed-citation xml:lang="en">Jin H., Wang H., Li X., et al. Economic burden of COVID-19, China, January-March, 2020: a cost-of-illness study. Bull World Health Organ. 2021; 99 (2): 112–24. https://doi.org/10.2471/BLT.20.267112.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Anser M.K., Sharif M., Khan M.A., et al. Demographic, psychological, and environmental factors affecting student's health during the COVID-19 pandemic: on the rocks. Environ Sci Pollut Res. 2021; 28: 31596–606. https://doi.org/10.1007/s11356-021-12991-x.</mixed-citation><mixed-citation xml:lang="en">Anser M.K., Sharif M., Khan M.A., et al. Demographic, psychological, and environmental factors affecting student's health during the COVID-19 pandemic: on the rocks. Environ Sci Pollut Res. 2021; 28: 31596–606. https://doi.org/10.1007/s11356-021-12991-x.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Eilersen A., Sneppen K. Cost-benefit of limited isolation and testing in COVID-19 mitigation. Sci Rep. 2020; 10 (1): 18543. https://doi.org/10.1038/s41598-020-75640-2.</mixed-citation><mixed-citation xml:lang="en">Eilersen A., Sneppen K. Cost-benefit of limited isolation and testing in COVID-19 mitigation. Sci Rep. 2020; 10 (1): 18543. https://doi.org/10.1038/s41598-020-75640-2.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Risko N., Werner K., Offorjebe O.A., et al. Cost-effectiveness and return on investment of protecting health workers in low- and middle income countries during the COVID-19 pandemic. PLoS One. 2020; 15 (10): e0240503. https://doi.org/10.1371/journal.pone.0240503.</mixed-citation><mixed-citation xml:lang="en">Risko N., Werner K., Offorjebe O.A., et al. Cost-effectiveness and return on investment of protecting health workers in low- and middle income countries during the COVID-19 pandemic. PLoS One. 2020; 15 (10): e0240503. https://doi.org/10.1371/journal.pone.0240503.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Молочков А.В., Каратеев Д.Е., Огнева Е.Ю. и др. Коморбидные заболевания и прогнозирование исхода COVID-19: результаты наблюдения 13 585 больных, находившихся на стационарном лечении в больницах Московской области. Альманах клинической медицины. 2020; 48 (S1): 1–10. https://doi.org/10.18786/2072-0505-2020-48-040.</mixed-citation><mixed-citation xml:lang="en">Molochkov A.V., Karateev D.E., Ogneva E.Yu., et al. Comorbidities and predicting the outcome of COVID-19: the treatment results of 13,585 patients hospitalized in the Moscow Region. Almanac of Clinical Medicine. 2020; 48 (S1): 1–10 (in Russ.). https://doi.org/10.18786/2072-0505-2020-48-040.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kouidere A., Youssoufi L.E., Ferjouchia H., et al. Optimal control of mathematical modeling of the spread of the COVID-19 pandemic with highlighting the negative impact of quarantine on diabetics people with cost-effectiveness. Chaos Solitons Fractals. 2021; 145: 110777. https://doi.org/10.1016/j.chaos.2021.110777.</mixed-citation><mixed-citation xml:lang="en">Kouidere A., Youssoufi L.E., Ferjouchia H., et al. Optimal control of mathematical modeling of the spread of the COVID-19 pandemic with highlighting the negative impact of quarantine on diabetics people with cost-effectiveness. Chaos Solitons Fractals. 2021; 145: 110777. https://doi.org/10.1016/j.chaos.2021.110777.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Baggett T.P., Scott J.A., Le M.H., et al. Clinical outcomes, costs, and cost-effectiveness of strategies for adults experiencing sheltered homelessness during the COVID-19 pandemic. JAMA Netw Open. 2020; 3 (12): e2028195. https://doi.org/10.1001/jamanetworkopen.2020.28195.</mixed-citation><mixed-citation xml:lang="en">Baggett T.P., Scott J.A., Le M.H., et al. Clinical outcomes, costs, and cost-effectiveness of strategies for adults experiencing sheltered homelessness during the COVID-19 pandemic. JAMA Netw Open. 2020; 3 (12): e2028195. https://doi.org/10.1001/jamanetworkopen.2020.28195.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hota S., Fried E., Burry L., et al. Preparing your intensive care unit for the second wave of H1N1 and future surges. Crit Care Med. 2010; 38 (4 Suppl.): e110–9. https://doi.org/10.1097/CCM.0b013e3181c66940.</mixed-citation><mixed-citation xml:lang="en">Hota S., Fried E., Burry L., et al. Preparing your intensive care unit for the second wave of H1N1 and future surges. Crit Care Med. 2010; 38 (4 Suppl.): e110–9. https://doi.org/10.1097/CCM.0b013e3181c66940.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">COVID19Surge: software to estimate the impact of COVID-19 pandemic on hospital surge capacity (Beta test version). URL: https://www.cdc.gov/coronavirus/2019-ncov/downloads/covid19surge/COVID19Surge-Manual.pdf (дата обращения 28.05.2021).</mixed-citation><mixed-citation xml:lang="en">COVID19Surge: software to estimate the impact of COVID-19 pandemic on hospital surge capacity (Beta test version). Available at: https://www.cdc.gov/coronavirus/2019-ncov/downloads/covid19surge/COVID19Surge-Manual.pdf (accessed 28.05.2021).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Aziz S., Arabi Y.M., Alhazzani W., et al. Managing ICU surge during the COVID-19 crisis: rapid guidelines. Intensive Care Med. 2020; 46: 1303–25. https://doi.org/10.1007/s00134-020-06092-5.</mixed-citation><mixed-citation xml:lang="en">Aziz S., Arabi Y.M., Alhazzani W., et al. Managing ICU surge during the COVID-19 crisis: rapid guidelines. Intensive Care Med. 2020; 46: 1303–25. https://doi.org/10.1007/s00134-020-06092-5.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Llorens P., Moreno-Pérez O., Espinosa B., et al. An integrated emergency department/hospital at home model in mild COVID-19 pneumonia: feasibility and outcomes after discharge from the emergency department. Intern Emerg Med. 2021; 16: 1673–82. https://doi.org/10.1007/s11739-021-02661-8.</mixed-citation><mixed-citation xml:lang="en">Llorens P., Moreno-Pérez O., Espinosa B., et al. An integrated emergency department/hospital at home model in mild COVID-19 pneumonia: feasibility and outcomes after discharge from the emergency department. Intern Emerg Med. 2021; 16: 1673–82. https://doi.org/10.1007/s11739-021-02661-8.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ding Q., Zhao H. Study on e-commerce logistics cost control methods in the context of COVID-19 prevention and control. Soft Comput. 2021; 25: 11955–63. https://doi.org/10.1007/s00500-021-05624-5.</mixed-citation><mixed-citation xml:lang="en">Ding Q., Zhao H. Study on e-commerce logistics cost control methods in the context of COVID-19 prevention and control. Soft Comput. 2021; 25: 11955–63. https://doi.org/10.1007/s00500-021-05624-5.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Leonardi Vinci D., Meccio A., Provenzani A., et al. The European COVID-19 drugs calculation tool: an aid for the estimation of the drugs needed during the SARS-CoV 2 pandemic. Eur J Hosp Pharm. 2021 Feb: ejhpharm-2020-002633. https://doi.org/10.1136/ejhpharm-2020-002633.</mixed-citation><mixed-citation xml:lang="en">Leonardi Vinci D., Meccio A., Provenzani A., et al. The European COVID-19 drugs calculation tool: an aid for the estimation of the drugs needed during the SARS-CoV 2 pandemic. Eur J Hosp Pharm. 2021 Feb: ejhpharm-2020-002633. https://doi.org/10.1136/ejhpharm-2020-002633.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cleary S.M., Wilkinson T., Tamandjou Tchuem C.R., et al. Cost effectiveness of intensive care for hospitalized COVID-19 patients: experience from South Africa. BMC Health Serv Res. 2021; 21 (1): 82. https://doi.org/10.1186/s12913-021-06081-4.</mixed-citation><mixed-citation xml:lang="en">Cleary S.M., Wilkinson T., Tamandjou Tchuem C.R., et al. Cost effectiveness of intensive care for hospitalized COVID-19 patients: experience from South Africa. BMC Health Serv Res. 2021; 21 (1): 82. https://doi.org/10.1186/s12913-021-06081-4.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gandjour A. How many intensive care beds are justifiable for hospital pandemic preparedness? A cost-effectiveness analysis for COVID-19 in Germany. Appl Health Econ Health Policy. 2021; 19 (2): 181–90. https://doi.org/10.1007/s40258-020-00632-2.</mixed-citation><mixed-citation xml:lang="en">Gandjour A. How many intensive care beds are justifiable for hospital pandemic preparedness? A cost-effectiveness analysis for COVID-19 in Germany. Appl Health Econ Health Policy. 2021; 19 (2): 181–90. https://doi.org/10.1007/s40258-020-00632-2.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Anand N., Sabarinath A., Geetha S., Somanath S. Predicting the spread of COVID19 using SIR model augmented to incorporate quarantine and testing. Trans Indian Natl Acad Eng. 2020; 5: 141–8. https://doi.org/10.1007/s41403-020-00151-5.</mixed-citation><mixed-citation xml:lang="en">Anand N., Sabarinath A., Geetha S., Somanath S. Predicting the spread of COVID19 using SIR model augmented to incorporate quarantine and testing. Trans Indian Natl Acad Eng. 2020; 5: 141–8. https://doi.org/10.1007/s41403-020-00151-5.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Du Z., Pandey A., Bai Y., et al. Comparative cost-effectiveness of SARS-CoV-2 testing strategies in the USA: a modelling study. Lancet Public Health. 2021; 6 (3): e184–91. https://doi.org/10.1016/S2468-2667(21)00002-5.</mixed-citation><mixed-citation xml:lang="en">Du Z., Pandey A., Bai Y., et al. Comparative cost-effectiveness of SARS-CoV-2 testing strategies in the USA: a modelling study. Lancet Public Health. 2021; 6 (3): e184–91. https://doi.org/10.1016/S2468-2667(21)00002-5.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Jo Y., Jamieson L., Edoka I., et al. Cost-effectiveness of remdesivir and dexamethasone for COVID-19 treatment in South Africa. Open Forum Infect Dis. 2021; 8 (3): ofab040. https://doi.org/10.1093/ofid/ofab040.</mixed-citation><mixed-citation xml:lang="en">Jo Y., Jamieson L., Edoka I., et al. Cost-effectiveness of remdesivir and dexamethasone for COVID-19 treatment in South Africa. Open Forum Infect Dis. 2021; 8 (3): ofab040. https://doi.org/10.1093/ofid/ofab040.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kerboua K.E. NLR: a cost-effective nomogram to guide therapeutic interventions in COVID-19. Immunol Invest. 2021; 50 (1): 92–100. https://doi.org/10.1080/08820139.2020.1773850.</mixed-citation><mixed-citation xml:lang="en">Kerboua K.E. NLR: a cost-effective nomogram to guide therapeutic interventions in COVID-19. Immunol Invest. 2021; 50 (1): 92–100. https://doi.org/10.1080/08820139.2020.1773850.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Балыкова Л.А., Говоров А.В., Васильев А.О. и др. Особенности коронавирусной инфекции COVID-19 и возможности раннего начала этиотропной терапии. Результаты клинического применения фавипиравира. Инфекционные болезни. 2020; 18 (3): 30–40. https://doi.org/10.20953/1729-9225-2020-3-30-40.</mixed-citation><mixed-citation xml:lang="en">Balykova L.A., Govorov A.V., Vasilyev A.O., et al. Characteristics of covid-19 and possibilities of early causal therapy. Results of favipiravir use in clinical practice. Infectious Diseases. 2020; 18 (3): 30–40 (in Russ.). https://doi.org/10.20953/1729-9225-2020-3-30-40.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Мишинова С.А., Журавков А.А., Журавко В.К. Назначение официально не разрешенных к применению лекарственных средств и использование лекарственных средств с нарушением инструкции по применению: фокус на COVID-19. Качественная клиническая практика. 2020; S4: 120–9. https://doi.org/10.37489/2588-0519-2020-S4-120-129.</mixed-citation><mixed-citation xml:lang="en">Mishinova S.A., Zhuravkov A.A., Zhuravko V.K. Use of unlicensed drugs and off-label drug use: focus on COVID-19. Kachestvennaya klinicheskaya praktika / Good Clinical Practice. 2020; S4: 120–9 (in Russ). https://doi.org/10.37489/2588-0519-2020-S4-120-129.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Шулакова О.А., Зырянов С.К., Гуревич К.Г. Использование лекарственных средств off label при лечении инфекции мочевыводящих путей у новорожденных. Экспериментальная и клиническая фармакология. 2015; 78 (12): 36–40. https://doi.org/10.30906/0869-2092-2015-78-12-36-40.</mixed-citation><mixed-citation xml:lang="en">Shulakova O.A., Zyryanov S.K., Gurevich K.G. Off-label drug usage in the treatment of urinary tract infection of newborns. Eksperimental'naya i klinicheskaya farmakologiya / Experimental and Clinical Pharmacology. 2015; 78 (12): 36–40 (in Russ). https://doi.org/10.30906/0869-2092-2015-78-12-36-40.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Smoke S.M., Raja K., Hilden P., Daniel N.M. Early clinical outcomes with tocilizumab for severe COVID-19: a two-centre retrospective study. Int J Antimicrob Agents. 2021; 57 (2): 106265. https://doi.org/10.1016/j.ijantimicag.2020.106265.</mixed-citation><mixed-citation xml:lang="en">Smoke S.M., Raja K., Hilden P., Daniel N.M. Early clinical outcomes with tocilizumab for severe COVID-19: a two-centre retrospective study. Int J Antimicrob Agents. 2021; 57 (2): 106265. https://doi.org/10.1016/j.ijantimicag.2020.106265.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kulanthaivel S., Kaliberdenko V.B., Balasundaram K. Tocilizumab in Sars-CoV-2 patients with the syndrome of cytokine storm; a narrative review. Rev Recent Clin Trails. 2021; 16 (2): 138–45. https://doi.org/10.2174/1574887115666200917110954.</mixed-citation><mixed-citation xml:lang="en">Kulanthaivel S., Kaliberdenko V.B., Balasundaram K. Tocilizumab in Sars-CoV-2 patients with the syndrome of cytokine storm; a narrative review. Rev Recent Clin Trails. 2021; 16 (2): 138–45. https://doi.org/10.2174/1574887115666200917110954.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Nasonov E., Samsonov M. The role of interleukin 6 inhibitors in therapy of severe COVID-19. Biomed Pharmacother. 2020; 131: 110698. https://doi.org/10.1016/j.biopha.2020.110698.</mixed-citation><mixed-citation xml:lang="en">Nasonov E., Samsonov M. The role of interleukin 6 inhibitors in therapy of severe COVID-19. Biomed Pharmacother. 2020; 131: 110698. https://doi.org/10.1016/j.biopha.2020.110698.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Tang Y., Liu J., Zhang D., et al. Cytokine storm in COVID-19: the current evidence and treatment strategies. Front Immunol. 2020; 11: 1708. https://doi.org/10.3389/fimmu.2020.01708.</mixed-citation><mixed-citation xml:lang="en">Tang Y., Liu J., Zhang D., et al. Cytokine storm in COVID-19: the current evidence and treatment strategies. Front Immunol. 2020; 11: 1708. https://doi.org/10.3389/fimmu.2020.01708.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kaye A.G., Siegel R. The efficacy of IL-6 inhibitor tocilizumab in reducing severe COVID-19 mortality: a systematic review. Peer J. 2020; 8: e10322. https://doi.org/10.7717/peerj.10322.</mixed-citation><mixed-citation xml:lang="en">Kaye A.G., Siegel R. The efficacy of IL-6 inhibitor tocilizumab in reducing severe COVID-19 mortality: a systematic review. Peer J. 2020; 8: e10322. https://doi.org/10.7717/peerj.10322.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Boregowda U., Perisetti A., Nanjappa A., Gajendran M. Addition of tocilizumab to the standard of care reduces mortality in severe COVID-19: a systematic review and meta-analysis. Front Med (Lausanne). 2020; 7: 586221. https://doi.org/10.3389/fmed.2020.586221.</mixed-citation><mixed-citation xml:lang="en">Boregowda U., Perisetti A., Nanjappa A., Gajendran M. Addition of tocilizumab to the standard of care reduces mortality in severe COVID-19: a systematic review and meta-analysis. Front Med (Lausanne). 2020; 7: 586221. https://doi.org/10.3389/fmed.2020.586221.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Uslu S. Effectiveness of tocilizumab in a COVID-19 patient with cytokine release syndrome. Eur J Case Rep Intern Med. 2020; 7 (6): 001731. https://doi.org/10.12890/2020_001731.</mixed-citation><mixed-citation xml:lang="en">Uslu S. Effectiveness of tocilizumab in a COVID-19 patient with cytokine release syndrome. Eur J Case Rep Intern Med. 2020; 7 (6): 001731. https://doi.org/10.12890/2020_001731.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Du P., Geng J., Wang F., et al. Role of IL-6 inhibitor in treatment of COVID-19-related cytokine release syndrome. Int J Med Sci. 2021; 18 (6): 1356–62. https://doi.org/10.7150/ijms.53564.</mixed-citation><mixed-citation xml:lang="en">Du P., Geng J., Wang F., et al. Role of IL-6 inhibitor in treatment of COVID-19-related cytokine release syndrome. Int J Med Sci. 2021; 18 (6): 1356–62. https://doi.org/10.7150/ijms.53564.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">De Stefano L., Bobbio-Pallavicini F., Manzo A., et al. A “Window of Therapeutic Opportunity” for anti-cytokine therapy in patients with coronavirus disease 2019. Front Immunol. 2020; 11: 572635. https://doi.org/10.3389/fimmu.2020.572635.</mixed-citation><mixed-citation xml:lang="en">De Stefano L., Bobbio-Pallavicini F., Manzo A., et al. A “Window of Therapeutic Opportunity” for anti-cytokine therapy in patients with coronavirus disease 2019. Front Immunol. 2020; 11: 572635. https://doi.org/10.3389/fimmu.2020.572635.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Deckert A., Anders S., de Allegri M., et al. Effectiveness and cost effectiveness of four different strategies for SARS-CoV-2 surveillance in the general population (CoV-Surv Study): a structured summary of a study protocol for a cluster-randomised, two-factorial controlled trial. Trials. 2021; 22 (1): 39. https://doi.org/10.1186/s13063-020-04982-z.</mixed-citation><mixed-citation xml:lang="en">Deckert A., Anders S., de Allegri M., et al. Effectiveness and cost effectiveness of four different strategies for SARS-CoV-2 surveillance in the general population (CoV-Surv Study): a structured summary of a study protocol for a cluster-randomised, two-factorial controlled trial. Trials. 2021; 22 (1): 39. https://doi.org/10.1186/s13063-020-04982-z.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Kouidere A., Kada D., Balatif O., et al. Optimal control approach of a mathematical modeling with multiple delays of the negative impact of delays in applying preventive precautions against the spread of the COVID-19 pandemic with a case study of Brazil and cost-effectiveness. Chaos Solitons Fractals. 2021; 142: 110438. https://doi.org/10.1016/j.chaos.2020.110438.</mixed-citation><mixed-citation xml:lang="en">Kouidere A., Kada D., Balatif O., et al. Optimal control approach of a mathematical modeling with multiple delays of the negative impact of delays in applying preventive precautions against the spread of the COVID-19 pandemic with a case study of Brazil and cost-effectiveness. Chaos Solitons Fractals. 2021; 142: 110438. https://doi.org/10.1016/j.chaos.2020.110438.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">ICU bed reserve capacity for COVID-19 cost effective in Germany. PharmacoEcon Outcomes News. 2021; 870 (1): 10. https://doi.org/10.1007/s40274-021-7413-9.</mixed-citation><mixed-citation xml:lang="en">ICU bed reserve capacity for COVID-19 cost effective in Germany. PharmacoEcon Outcomes News. 2021; 870 (1): 10. https://doi.org/10.1007/s40274-021-7413-9.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Swain K.C., Singha C. Low-cost technology for COVID-19 infection detection through smell loss test: an overview. Trop Biomed. 2020; 37 (3): 671–82. https://doi.org/10.47665/tb.37.3.671.</mixed-citation><mixed-citation xml:lang="en">Swain K.C., Singha C. Low-cost technology for COVID-19 infection detection through smell loss test: an overview. Trop Biomed. 2020; 37 (3): 671–82. https://doi.org/10.47665/tb.37.3.671.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Durner J., Burggraf S., Czibere L., et al. Fast and cost-effective screening for SARS-CoV-2 variants in a routine diagnostic setting. Dent Mater. 2021; 37 (3): e95–7. https://doi.org/10.1016/j.dental.2021.01.015.</mixed-citation><mixed-citation xml:lang="en">Durner J., Burggraf S., Czibere L., et al. Fast and cost-effective screening for SARS-CoV-2 variants in a routine diagnostic setting. Dent Mater.2021; 37 (3): e95–7. https://doi.org/10.1016/j.dental.2021.01.015.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Agarwal R., Gupta E., Dubey S., et al. Pooled nasopharyngeal swab collection in a single vial for the diagnosis of SARS CoV-2 infection: an effective cost saving method. Indian J Med Microbiol. 2021; 39 (2): 231–4. https://doi.org/10.1016/j.ijmmb.2020.11.002.</mixed-citation><mixed-citation xml:lang="en">Agarwal R., Gupta E., Dubey S., et al. Pooled nasopharyngeal swab collection in a single vial for the diagnosis of SARS CoV-2 infection: an effective cost saving method. Indian J Med Microbiol. 2021; 39 (2): 231–4. https://doi.org/10.1016/j.ijmmb.2020.11.002.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Neilan A.M., Losina E., Bangs A.C., et al. Clinical impact, costs, and cost-effectiveness of expanded SARS-CoV-2 testing in Massachusetts. Clin Infect Dis. 2020: ciaa1418. https://doi.org/10.1093/cid/ciaa1418.</mixed-citation><mixed-citation xml:lang="en">Neilan A.M., Losina E., Bangs A.C., et al. Clinical impact, costs, and cost-effectiveness of expanded SARS-CoV-2 testing in Massachusetts. Clin Infect Dis. 2020: ciaa1418. https://doi.org/10.1093/cid/ciaa1418.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Bagepally B.S., Haridoss M., Natarajan M., et al. Cost-effectiveness of surgical mask, N-95 respirator, hand-hygiene and surgical mask with hand hygiene in the prevention of COVID-19: cost effectiveness analysis from Indian context. Clin Epidemiol Glob Health. 2021; 10: 100702. https://doi.org/10.1016/j.cegh.2021.100702.</mixed-citation><mixed-citation xml:lang="en">Bagepally B.S., Haridoss M., Natarajan M., et al. Cost-effectiveness of surgical mask, N-95 respirator, hand-hygiene and surgical mask with hand hygiene in the prevention of COVID-19: cost effectiveness analysis from Indian context. Clin Epidemiol Glob Health. 2021; 10: 100702. https://doi.org/10.1016/j.cegh.2021.100702.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Chaturvedi S., Gupta A., Krishnan S.V., Bhat A.K. Design, usage and review of a cost effective and innovative face shield in a tertiary care teaching hospital during COVID-19 pandemic. J Orthop. 2020; 21: 331–6. https://doi.org/10.1016/j.jor.2020.07.003.</mixed-citation><mixed-citation xml:lang="en">Chaturvedi S., Gupta A., Krishnan S.V., Bhat A.K. Design, usage and review of a cost effective and innovative face shield in a tertiary care teaching hospital during COVID-19 pandemic. J Orthop. 2020; 21: 331–6. https://doi.org/10.1016/j.jor.2020.07.003.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Asamoah J.K., Owusu M.A., Jin Z., et al. Global stability and cost effectiveness analysis of COVID-19 considering the impact of the environment: using data from Ghana. Chaos Solitons Fractals. 2020; 140: 110103. https://doi.org/10.1016/j.chaos.2020.110103.</mixed-citation><mixed-citation xml:lang="en">Asamoah J.K., Owusu M.A., Jin Z., et al. Global stability and cost effectiveness analysis of COVID-19 considering the impact of the environment: using data from Ghana. Chaos Solitons Fractals. 2020; 140: 110103. https://doi.org/10.1016/j.chaos.2020.110103.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Ebigbo A., Römmele C., Bartenschlager C., et al. Cost-effectiveness analysis of SARS-CoV-2 infection prevention strategies including pre endoscopic virus testing and use of high risk personal protective equipment. Endoscopy. 2021; 53 (2): 156–61. https://doi.org/10.1055/a-1294-0427.</mixed-citation><mixed-citation xml:lang="en">Ebigbo A., Römmele C., Bartenschlager C., et al. Cost-effectiveness analysis of SARS-CoV-2 infection prevention strategies including pre endoscopic virus testing and use of high risk personal protective equipment. Endoscopy. 2021; 53 (2): 156–61. https://doi.org/10.1055/a-1294-0427.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Yu Y., Lau J.T., Lau M.M. Understanding the prevalence and associated factors of behavioral intention of COVID-19 vaccination under specific scenarios combining effectiveness, safety, and cost in the Hong Kong Chinese general population. Int J Health Policy Manag. 2021 Jan 18. https://doi.org/10.34172/ijhpm.2021.02.</mixed-citation><mixed-citation xml:lang="en">Yu Y., Lau J.T., Lau M.M. Understanding the prevalence and associated factors of behavioral intention of COVID-19 vaccination under specific scenarios combining effectiveness, safety, and cost in the Hong Kong Chinese general population. Int J Health Policy Manag. 2021 Jan 18. https://doi.org/10.34172/ijhpm.2021.02.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">COVID-19 vaccination predicted to be cost effective in USA. PharmacoEcon Outcomes News. 2021; 871 (1): 10. https://doi.org/10.1007/s40274-021-7448-y.</mixed-citation><mixed-citation xml:lang="en">COVID-19 vaccination predicted to be cost effective in USA. PharmacoEcon Outcomes News. 2021; 871 (1): 10. https://doi.org/10.1007/s40274-021-7448-y.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Kohli M., Maschio M., Becker D., Weinstein M.C. The potential public health and economic value of a hypothetical COVID-19 vaccine in the United States: use of cost-effectiveness modeling to inform vaccination prioritization. Vaccine. 2021; 39 (7): 1157–64. https://doi.org/10.1016/j.vaccine.2020.12.078.</mixed-citation><mixed-citation xml:lang="en">Kohli M., Maschio M., Becker D., Weinstein M.C. The potential public health and economic value of a hypothetical COVID-19 vaccine in the United States: use of cost-effectiveness modeling to inform vaccination prioritization. Vaccine. 2021; 39 (7): 1157–64. https://doi.org/10.1016/j.vaccine.2020.12.078.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Sookaromdee P., Wiwanitkit V. New COVID-19 vaccines, its cost and shelf life: a cost effectiveness analysis. Arch Med Res. 2021; 52 (4): 453. https://doi.org/10.1016/j.arcmed.2020.12.008.</mixed-citation><mixed-citation xml:lang="en">Sookaromdee P., Wiwanitkit V. New COVID-19 vaccines, its cost and shelf life: a cost effectiveness analysis. Arch Med Res. 2021; 52 (4): 453. https://doi.org/10.1016/j.arcmed.2020.12.008.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Berry D.A., Berry S., Hale P., et al. A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates. PLoS One. 2020; 15 (12): e0244418. https://doi.org/10.1371/journal.pone.0244418.</mixed-citation><mixed-citation xml:lang="en">Berry D.A., Berry S., Hale P., et al. A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates. PLoS One. 2020; 15 (12): e0244418. https://doi.org/10.1371/journal.pone.0244418.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Gu T., Yao L., Meng X., et al. A cost-effective plan for global testing – an infection rate stratified, algorithm guided, multiple-level, continuously pooled testing strategy. Sci Total Environ. 2021; 765: 144251. https://doi.org/10.1016/j.scitotenv.2020.144251.</mixed-citation><mixed-citation xml:lang="en">Gu T., Yao L., Meng X., et al. A cost-effective plan for global testing – an infection rate stratified, algorithm guided, multiple-level, continuously pooled testing strategy. Sci Total Environ. 2021; 765: 144251. https://doi.org/10.1016/j.scitotenv.2020.144251.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
