farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLC10.17749/2070-4909/farmakoekonomika.2020.070farmaec-446Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ ПУБЛИКАЦИИPeptides contained in the composition of Laennec that contribute to the treatment of hyperferritinemia and iron overload disordersПептиды в составе препарата Лаеннек, способствующие устранению гиперферритинемии и перегрузки железомhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна - доктор медицинских наук, проф., ведущий научный сотрудник, научный руководитель Института фармакоинформатики, ФИЦ «Информатика и Управление» РАН; ведущий научный сотрудник Центра хранения и анализа больших данных, МГУ, Scopus Author ID: 7003589812; WoS Researcher ID: J-4946-2017; РИНЦ SPIN-код: 6317-9833; eLIBRARY ID: 94901. E-mail

Ул. Вавилова, д. 44, корп. 2, Москва 119333; Ленинские горы, д. 1, Москва 119991

Olga A. Gromova - MD, Dr Sci Med, Professor, Senior Researcher, Scientific Director of the Federal Research Center Computer Sciences and Control, RAS; Leading Researcher, Center for Big Data Analysis, MSU, Scopus Author ID: 7003589812; WoS Researcher ID: J-4946-2017; RSCI SPIN-code: 6317-9833; eLIBRARY ID: 94901

44-2 Vavilova Str., Moscow 119333; 1 Leninskie gory, Moscow 119991

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич - кандидат физико-математических наук, кандидат химических наук, старший научный сотрудник, Институт фармакоинформатики, ФИЦ «Информатика и Управление» РАН, ScopusAuthorID: 7003300274; WoSResearcherID: C-7683-2018; РИНЦ SPIN-код: 1375-1114; eLIBRARYID: 54104.

Ул. Вавилова, д. 44, корп. 2, Москва 119333; Ленинские горы, д. 1, Москва 119991

Ivan Yu. Torshin - MD, PhD, Senior Researcher, Federal Research Center Computer Sciences and Control, RAS; Big Data Storage and Analysis Center, MSU; Scopus Author ID: 7003300274; WoS Researcher ID: C-7683-2018; RSCI SPIN-code: 1375-1114; eLIBRARY ID: 54104.

44-2 Vavilova Str., Moscow 119333; 1 Leninskie gory, Moscow 119991

https://orcid.org/0000-0003-4120-1071МаксимовВ. А.MaksimovV. A.

Максимов Валерий Алексеевич - доктор медицинских наук, профессор, заслуженный деятель науки Российской Федерации, заслуженный врач Российской Федерации, профессор кафедры диетологии и нутрициологии ФГБОУ ДПО РМАНПО.

Ул. Баррикадная, д. 2, стр. 1, Москва 123995

Valery A. Maksimov - MD, Dr Sci Med, Professor, Honored Scientist of the Russian Federation, Honored Doctor of the Russian Federation; Professor of the Department of Dietetics and Nutrition.

2-1 Barrikadnaya Str., 123995 Moscow

https://orcid.org/0000-0002-5070-5450ЧучалинА. Г.ChuchalinA. G.

Чучалин Александр Григорьевич - доктор медицинских наук, академик РАН, пульмонолог, заведующий кафедрой госпитальной терапии педиатрического факультета РНИМУ им. Н.И. Пирогова.

Alexander G. Chuchalin - MD, Dr Sci Med, Academician of the Russian Academy of Sciences, Pulmonologist, Head of the Department of Hospital Therapy of the Pediatric Faculty of the RNRMU named after N.I. Pirogov.

https://orcid.org/0000-0002-4532-4274ЗгодаВ. Г.ZgodaV. G.

Згода Виктор Гаврилович - доктор биологических наук, Центр коллективного пользования «Протеом человека», ИБМХ им. В.Н. Ореховича.

Ул. Погодинская, д. 10, стр. 8, Москва 119121

Victor G. Zgoda - MD, Dr Sci Med.

10 Pogodinskaya Str., Moscow 119121

https://orcid.org/0000-0001-7507-191XГромовА. Н.GromovА. N.

Громов Андрей Николаевич - инженер-исследователь Института фармакоинформатики, ФИЦ «Информатика и Управление» РАН; Центр хранения и анализа больших данных, МГУ, ScopusAuthorID: 7102053964; WoSResearcherID: C-7476-2018; РИНЦ SPIN-код: 8034-7910; eLIBRARYID: 15082.

Andrey N. Gromov - research engineer of the Federal Research Center Computer Sciences and Control, RAS; Researcher of the Center for Big Data Analysis, MSU; Scopus Author ID: 7102053964; WoS Researcher ID: C-7476-2018; RSCI SPIN-code: 8034-7910; eLIBRARY ID: 15082.

44-2 Vavilova Str., Moscow 119333; 1 Leninskie gory, Moscow 119991

https://orcid.org/0000-0002-2810-566XТихоноваО. В.TikhonovaO. V.

Тихонова Ольга Валентиновна – кандидат биологических наук, Центр коллективного пользования «Протеом человека», ИБМХ им. В.Н. Ореховича.

Ул. Погодинская, д. 10, стр. 8, Москва 119121

Olga V. Tikhonova - PhD (Biology).

10 Pogodinskaya Str., Moscow 119121

Федеральный исследовательский центр Информатика и управление РАН (ФИЦИУ РАН); Центр хранения и анализа больших данных, Федеральное государственное бюджетное образовательное учреждение высшего образования Московский государственный университет имени М.В. ЛомоносоваРоссияFederal Research Center Computer Sciences and Control, Russian Academy of Sciences; Moscow State UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования Российская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Postgraduate EducationRussian FederationФедеральное государственное автономное образовательное учреждение высшего образования Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Министерства здравоохранения Российской ФедерацииРоссияRussian National Research Medical UniversityRussian FederationФедеральное государственное бюджетное научное учреждение Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича (ИБМХ)РоссияInstitute of Biomedical Chemistry (IBMC)Russian Federation202006022021134413425Copyright © Gromova O.A., Torshin I.Y., Maksimov V.A., Chuchalin A.G., Zgoda V.G., Gromov А.N., Tikhonova O.V., 20212021Громова О.А., Торшин И.Ю., Максимов В.А., Чучалин А.Г., Згода В.Г., Громов А.Н., Тихонова О.В.Gromova O.A., Torshin I.Y., Maksimov V.A., Chuchalin A.G., Zgoda V.G., Gromov А.N., Tikhonova O.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/446Introduction

Introduction. Hemosiderosis is a pathologic condition that accompanies liver, lung, and other organ diseases. Polypeptide-containing drug Laennec contributes to the elimination of excessive iron deposits in tissues.

Aim

Aim. The study was aimed to identify peptides contained in the composition of the drug that take part in the regulation of iron homeostasis and correction of hemosiderosis and hyperferritinemia.

Materials and Methods

Materials and Methods. The study of the drug composition was conducted with hybrid mass-spectrometry and modern methods of analysis of Big Data based on the topological approach to recognition.

Results

Results. The preparation contains 19 peptides that are potentially important for the regulation of iron homeostasis. These peptides help to treat the disorders of iron metabolism by regulating the levels of the main hormone of iron homeostasis hepcidin by reducing the synthesis of ferritin and by exhibiting anti-inflammatory and immunomodulatory effects.

Conclusion

Conclusion. The identified peptides allowed the authors to describe the molecular mechanisms of the iron overload elimination that are known from experimental and clinical studies of the analyzed polypeptide drug.

Введение

Введение. Гемосидероз – патологическое состояние, сопровождающее патологии печени, легких и других органов. Полипептидный препарат Лаеннек способствует элиминации избыточных отложений железа в тканях.

Цель

Цель. Идентификация в составе препарата пептидов, участвующих в регуляции гомеостаза железа, устранении гемосидероза и гиперферритинемии.

Материалы и методы

Материалы и методы. Исследование пептидного состава препарата с использованием гибридной масс-спектрометрии и современных методов анализа больших данных, основанных на топологической теории распознавания.

Результаты

Результаты. В составе препарата идентифицированы 19 пептидов, потенциально важных для регулировки гомеостаза железа. Регулируя уровни гепцидина, основного гормона гомеостаза железа, снижая синтез ферритина, а также проявляя противовоспалительные и иммуномодулирующие эффекты, эти пептиды способствуют устранению нарушений обмена железа.

Заключение

Заключение. Идентифицированные пептиды позволили описать молекулярные механизмы устранения перегрузки тканей железом, известные из экспериментальных и клинических исследований рассматриваемого полипептидного препарата.

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The authors declare that there are no conflicts of interest present.