farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLC10.17749/2070-4909/farmakoekonomika.2020.044farmaec-386Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ ПУБЛИКАЦИИCOVID-19 pandemic: protective role of vitamin DПандемия COVID-19: защитные роли витамина Dhttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

д.м.н., профессор, в.н.с., научный руководитель Института фармакоинформатики; в.н.с.

Author ID: 94901; Scopus Author ID: 7003589812;

WoS ResearcherID: J-4946-2017. РИНЦ SPIN-код: 6317-9833

ул. Вавилова, д. 44, корп. 2, Москва 119333, Россия

Ленинские горы, д. 1, Москва 119991, Россия

MD, Dr Sci Med, Professor, Senior Researcher, Scientific Director; Leading Researcher, Center for Big Data Analysis, Moscow State University

Author ID: 94901; Scopus Author ID: 7003589812;

WoS ResearcherID: J-4946-2017. RSCI SPIN-code: 6317-9833 34A Kashirskoye Shosse, Moscow 115522, Russia

44-2 Vavilova Str., Moscow 119333, Russia

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

к.ф-м.н., к.х.н., с.н.с., Институт фармакоинформатики

Scopus Author ID: 7003300274; Author ID: 54104;

WoS ResearcherID: C-7683-2018. РИНЦ SPIN-код: 1375-1114

ул. Вавилова, д. 44, корп. 2, Москва 119333, Россия

Ленинские горы, д. 1, Москва 119991, Россия

MD, PhD, Senior Researcher, Federal Research Center “Informatics and Management”; Big Data Storage and Analysis Center,

Scopus Author ID: 7003300274; Author ID: 54104;

WoS ResearcherID: C-7683-2018. RSCI SPIN-code: 1375-1114 34A Kashirskoye Shosse, Moscow 115522, Russia

44-2 Vavilova Str., Moscow 119333, Russia

ГабдулинаГ. Х.GabdulinaG. Kh.

к.м. н, профессор кафедры общей врачебной практики №1 

ул. Толе Би, д. 92, Алматы 50012, Казахстан

Федеральный исследовательский центр «Информатика и управление» РАН (ФИЦ ИУ РАН); Центр хранения и анализа больших данных, Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М. В. Ломоносова»РоссияV.A. Nasonov Research Institute of Rheumatology; Federal Research Center “Informatics and Management of the Russian Academy of Sciences“Russian FederationНАО «Казахский национальный медицинский университет им. С. Д. Асфендиярова»КазахстанKazakh National Medical University named after S. D. AsfendiyarovaKazakhstan202008082020132132145Copyright © Gromova O.A., Torshin I.Y., Gabdulina G.K., 20202020Громова О.А., Торшин И.Ю., Габдулина Г.Х.Gromova O.A., Torshin I.Y., Gabdulina G.K.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/386Introduction

Introduction. The COVID-19 pandemic revealed the vulnerability of the general population to this infectious disease, which is determined by the lack of immunity to the new SARS-CoV-2 coronavirus and is characterized by cytokine storm in severe cases. One of the most important reasons for this vulnerability is a high occurrence rate of micronutrient deficiencies, and above all, vitamin D deficiency.

Aim

Aim. To systematize the available data on the role of vitamin D in the prevention of COVID-19 infection.

Materials and methods

Materials and methods. Systematic computer analysis of the entire array of available scientific publications on coronaviruses (21,300 publications in PUBMED and preprint repositories, including 7,500 publications on COVID-19 and SARS-CoV-2) was performed. The methods of topological and metric data analysis were used. About 50 most informative sections were identified that were mainly associated with COVID-19 / SARS-CoV-2. The analysis of the obtained “map” of molecular pathophysiology of COVID-19 was performed.

Results

Results. Vitamin D activates the expression of many genes involved in supporting the immunity against coronaviruses and other singlestranded RNA viruses (interferon-dependent protection). The results of the systematic analysis of the publications on coronavirus showed that vitamin D is important for attenuating the effects of the cytokine storm and compensating for chronic comorbid pathologies.

Conclusion

Conclusion. The compensation for vitamin D deficiency is an essential component of COVID-19 prevention. This tactics of prevention is less costly than managing patients with severe forms of COVID-19 and can help save public healthcare resources.  

Введение

Введение. Пандемия COVID-19 выявила уязвимость широких слоев населения к этому инфекционному заболеванию, определяющуюся отсутствием иммунитета к новому коронавирусу SARS-CoV-2 и цитокиновым штормом при тяжелом течении. Одной из важнейших причин этой уязвимости является широчайшее распространение микронутриентных дефицитов и, прежде всего, дефицита витамина D.

Цель

Цель. Систематизировать доступные данные о роли витамина D в профилактике инфекции COVID-19.

Материалы и методы

Материалы и методы. Систематический компьютерный анализ всего массива публикаций имеющейся научной литературы по коронавирусам (21300 публикаций в PUBMED и репозиториям препринтов, в т.ч. 7500 публикаций по COVID-19 и SARS-CoV-2). Использованы методы  топологического и метрического анализа данных. Выделены около 50 наиболее информативных рубрик, ассоциированных преимущественно с COVID-19/SARS-CoV-2. Выполнен анализ полученной  «карты» молекулярной патофизиологии COVID-19.

Результаты

Результаты. Витамин D активирует экспрессию многих генов, вовлеченных в поддержку  иммунитета против коронавирусов и других одноцепочечных РНК-вирусов (интерферон-зависимая защита). Результаты систематического анализа текстов публикаций по коронавирусам показали, что витамин D важен для ослабления эффектов цитокинового шторма и для компенсации хронических коморбидных патологий.

Заключение

Заключение. Таким образом, компенсация недостаточности витамина D – необходимая  составляющая профилактики COVID-19. Оказываясь менее затратной, чем ведение пациентов с тяжелым течением COVID-19, данная тактика может способствовать экономии ресурсов здравоохранения.

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The authors declare that there are no conflicts of interest present.