farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLC10.17749/2070-4909.2020.13.1.64-70farmaec-343Research ArticleReview articleОбзорная публикацияEconomic challenges of oncological diseases’ pharmacotherapyЭкономические проблемы фармакотерапии онкологических заболеванийhttps://orcid.org/0000-0003-4165-1726УшкаловаЕ. А.UshkalovaE. A.

Ушкалова Елена Андреевна – д.м.н., профессор, профессор кафедры общей и клинической фармакологии 

 

 Researcher ID: A-4765-2017. РИНЦ SPIN-код: 7722-5802

 

Elena A. Ushkalova – MD, Dr Sci Med, Professor, Department of General and Clinical Pharmacology

 Researcher ID: A-4765-2017. Scopus Author ID: 56633092200. RISIN SPIN-code: 7722-5802

https://orcid.org/0000-0002-6348-6867ЗыряновС. К.ZyryanovS. K.

Зырянов Сергей Кенсаринович – д.м.н., профессор, заведующий кафедрой общей и клинической фармакологии ; заместитель главного врача ГКБ 24 ДЗМ

Researcher ID:  D-8826-2012. РИНЦ SPIN-код: 2725-9981

ул. Миклухо-Маклая, д. 10/3, Москва 117198; ул. Писцовая, д. 10, Москва 27015

Sergey K. Zyryanov – MD, Dr Sci Med, Professor & Head, Department of General and Clinical Pharmacology; Deputy Chief Medical Officer, Clinical Hospital No. 24

Researcher ID: D-8826-2012. RISIN SPIN-code: 2725-9981

https://orcid.org/0000-0003-3089-1804ГопиенкоИ. А.GopienkoI. A.

Гопиенко Ирина Александровна – аспирант кафедры общей и клинической фармакологии

 РИНЦ SPIN-код: 8192-4441

ул. Миклухо-Маклая, д. 10/3, Москва 117198

Irina A. Gopienko – Postgraduate student, Department of General and Clinical Pharmacology

RISIN SPIN-code: 8192-4441

erin332@mail.ruФедеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов»РоссияPeoples’ Friendship University of RussiaRussian FederationФедеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов»; Государственное бюджетное учреждение города Москвы «Городская клиническая больница № 24 Департамента здравоохранения города Москвы»РоссияPeoples’ Friendship University of Russia; City Clinical Hospital No. 24 of the Moscow Department of HealthRussian Federation2020240420201316470Copyright © Ushkalova E.A., Zyryanov S.K., Gopienko I.A., 20202020Ушкалова Е.А., Зырянов С.К., Гопиенко И.А.Ushkalova E.A., Zyryanov S.K., Gopienko I.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/343

Oncological diseases rank high in the structure of population morbidity and mortality. They entail considerable direct and indirect economic costs. In the past decades, the cost of oncotherapy has increased significantly, which is largely conditioned by high prices of antitumor drugs, which on average increased by ten times in the past ten years. At the same time, many innovative medications have only minor advantages over cheaper old medications because they are registered based on the data on the achievement of the surrogate endpoint – extension of progression-free survival. The high cost of oncotherapy is associated with financial toxicity that affects negatively the patients’ quality of life, their adherence to treatment and consequently survival. To reduce the cost of oncotherapy, it is necessary to conduct pharma-economic analysis, the results of which can serve as the basis to negotiate price-cutting with the manufacturers, as well as to use high-quality generics and biosimilars as effective and safe as their originals, and to monitor effectiveness and safety of all antitumor drugs within the pharmacovigilance framework.

Онкологические заболевания занимают существенное место в структуре заболеваемости и смертности населения и сопряжены с высокими прямыми и непрямыми экономическими затратами. Стоимость лечения онкопатологий существенно выросла в последние десятилетия, что в значительной степени обусловлено высокими ценами противоопухолевых препаратов, которые за последние 10 лет увеличились в среднем в 10 раз. При этом многие инновационные препараты имеют лишь минимальные преимущества перед более дешевыми старыми препаратами, так как регистрируются на основании данных о достижении суррогатной конечной точки – удлинения периода без прогрессирования заболевания. Высокая стоимость терапии ассоциируется с финансовой токсичностью, негативно влияющей на качество жизни пациента, приверженностью лечению и выживаемостью. Для снижения стоимости лечения онкозаболеваний необходимо проведение фармакоэкономического анализа, результаты которого могут служить основанием для переговоров с производителями по поводу снижения цен, применение качественных генериков и биоаналогов, обладающих сходной эффективностью и безопасностью с оригинальными препаратами, а также мониторинг эффективности и безопасности всех противоопухолевых средств в рамках фармаконадзора.

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The authors declare that there are no conflicts of interest present.