farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLCfarmaec-22Research ArticleRussian StudiesРоссийские исследованияPHARMACOECONOMIC MODELING OF ANTIRETROVIRAL DRUGS USE DURING TREATMENT OF HIV INFECTIONФАРМАКОЭКОНОМИЧЕСКОЕ МОДЕЛИРОВАНИЕ ПРИМЕНЕНИЯ ПРЕПАРАТОВ АНТИРЕТРОВИРУСНОЙ ТЕРАПИИ ПРИ ЛЕЧЕНИИ ВИЧ-ИНФЕКЦИИЧибиляевВ. А.ChibilyaevV. A.

Лаборатория фармакоэкономических исследований

Laboratory of pharmacoeconomical research

КуликовА. Ю.KulikovA. Yu.

Лаборатория фармакоэкономических исследований

Laboratory of pharmacoeconomical research

ЯгудинаР. И.YagudinaR. I.

Лаборатория фармакоэкономических исследований

Laboratory of pharmacoeconomical research

ГБОУ ВПО «Первого МГМУ им. Сеченова», МоскваРоссияThe First MSMU named after I.M. SechenovRussian Federation201319032015622132Copyright © Chibilyaev V.A., Kulikov A.Y., Yagudina R.I., 20152015Чибиляев В.А., Куликов А.Ю., Ягудина Р.И.Chibilyaev V.A., Kulikov A.Y., Yagudina R.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/22

Comparative pharmacoeconomic analysis of two therapeutic strategy (the strategy A and the strategy B), which differ with the expansion of access to ART was conducted using deterministic model. The aim of this research was to optimize the therapy of HIV-infected people and determine the most effective therapeutic strategy. On the basis of obtained epidemiological data model determines the advantages of therapeutic strategy with higher access to ART (strategy B). In particular, the results of simulation showed that the application of ART allows to significantly reduce new HIV infections and deaths related to the virus. Use of ART allows to optimize the costs, the value of quality-adjusted life year (QALY) is growing, which makes it advisable to use ART in health care on larger scale.

Проведено фармакоэкономическое и фармакоэпи демиологическое исследование с целью оптимизации лечения больных ВИЧ-инфекцией и определения наиболее эффективной стратегии лечения больных с использованием препаратов антиретровирусной терапии (АРТ). Разработана детерминистиче ская модель распространения ВИЧ-инфекции в открытой популяции, охватывающая 20-летний период. На основании полученных эпидемиологических данных модель доказывает преимуще ства терапевтической стратегии с большей широтой предоставления АРТ (стратегии Б). В частности, результаты моделирования показали, что применение АРТ позволяет существенно снизить новые случаи заражения ВИЧ и летальных исходов, связанных с данным вирусом. Применение АРТ позволяет оптимизировать расходы, при этом значение показателя Дополнительный год жизни с поправкой на качество (QALY) растет, что делает целесообразным применение АРТ в практике здравоохранения в больших масштабах.

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The authors declare that there are no conflicts of interest present.