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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">farmaec</journal-id><journal-title-group><journal-title xml:lang="en">FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology</journal-title><trans-title-group xml:lang="ru"><trans-title>ФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2070-4909</issn><issn pub-type="epub">2070-4933</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2070-4909/farmakoekonomika.2026.325</article-id><article-id custom-type="elpub" pub-id-type="custom">farmaec-1384</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ ПУБЛИКАЦИИ</subject></subj-group></article-categories><title-group><article-title>Concepts aimed at improving pharmaceutical care for patients with socially significant diseases in Russia and worldwide</article-title><trans-title-group xml:lang="ru"><trans-title>Концепции совершенствования лекарственной помощи пациентам с социально значимыми заболеваниями в России и мире</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1377-4796</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гущина</surname><given-names>Ю. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Gushchina</surname><given-names>Yu. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гущина Юлия Шамилевна, доцент</p><p>ул. Миклухо-Маклая, д. 6, Москва 117198</p></bio><bio xml:lang="en"><p>Yulia Sh. Gushchina, Assoc. Prof.</p><p>6 Miklukho-Maklay Str., Moscow 117198</p></bio><email xlink:type="simple">gushchina-yush@rudn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7178-1260</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абрамов</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Abramov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абрамов Алексей Юрьевич, д.м.н., проф.</p><p>ул. Миклухо-Маклая, д. 6, Москва 117198</p></bio><bio xml:lang="en"><p>Aleksey Yu. Abramov, Dr. Sci. Med., Prof.</p><p>6 Miklukho-Maklay Str., Moscow 117198</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов им. Патриса Лумумбы»<country>Россия</country></aff><aff xml:lang="en">Peoples' Friendship University of Russia named after Patrice Lumumba<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>07</day><month>05</month><year>2026</year></pub-date><volume>1</volume><issue>19</issue><fpage>200</fpage><lpage>210</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Gushchina Y.S., Abramov A.Y., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Гущина Ю.Ш., Абрамов А.Ю.</copyright-holder><copyright-holder xml:lang="en">Gushchina Y.S., Abramov A.Y.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pharmacoeconomics.ru/jour/article/view/1384">https://www.pharmacoeconomics.ru/jour/article/view/1384</self-uri><abstract><p>Objective: To conduct a comparative analysis of concepts aimed at improving pharmaceutical care for patients with socially significant diseases in both Russia and other countries with the purpose of identifying priority development directions for the Russian system.Material and methods. A systematic search of scientific literature, regulatory documents, and statistical data for 2016–2025 was conducted using the PubMed/MEDLINE, CyberLeninka, and eLibrary databases. A comparative method was applied to analyze European, North American, and Russian pharmaceutical provision models. Their effectiveness was evaluated based on accessibility, financial sustainability, quality of care, and innovation criteria.Results. The European model is characterized by a high level of government funding (70–80%) and effective cost control mechanisms through health technology assessment institutions. The North American system demonstrates trends toward universal coverage with multiple funding sources. The Russian model provides 100% coverage for high-cost nosologies, however, the overall share of government funding reaches 40% with a significant regional differentiation in accessibility. Current trends include implementation of personalized medicine, targeted therapy, telemedicine, and risk-sharing agreements with pharmaceutical companies.Conclusion. Priority directions for improving the Russian system include unification of regional approaches, implementation of clinical and economic effectiveness assessment mechanisms, development of personalized medicine and digital technologies for pharmaceutical care management.</p></abstract><trans-abstract xml:lang="ru"><p>Цель: провести сравнительный анализ концепций совершенствования лекарственной помощи пациентам с социально значимыми заболеваниями в России и зарубежных странах для определения приоритетных направлений развития отечественной системы.Материал и методы. Осуществлен систематический поиск научной литературы, нормативно-правовых документов и статистических данных за период 2016–2025 гг. в базах данных PubMed/MEDLINE, КиберЛенинка и eLibrary. Применялся сравнительно-аналитический метод для сопоставления европейской, североамериканской и российской моделей лекарственного обеспечения. Оценка эффективности проводилась по критериям доступности, финансовой устойчивости, качества помощи и инновационности.Результаты. Европейская модель характеризуется высокой степенью государственного финансирования (70–80%) и эффективными механизмами контроля затрат через институты оценки медицинских технологий. Североамериканская система демонстрирует тенденции к универсализации покрытия при множественных источниках финансирования. Российская модель обеспечивает 100% покрытие высокозатратных нозологий, однако общая доля государственного финансирования составляет 40% при значительной региональной дифференциации доступности. Современные тенденции включают внедрение персонализированной медицины, таргетной терапии, телемедицины и соглашений о разделении рисков с фармацевтическими компаниями.Заключение. Приоритетными направлениями совершенствования российской системы являются унификация региональных подходов, внедрение механизмов оценки клинико-экономической эффективности, развитие персонализированной медицины и цифровых технологий управления лекарственной помощью.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>социально значимые заболевания</kwd><kwd>лекарственная помощь</kwd><kwd>высокозатратные нозологии</kwd><kwd>персонализированная медицина</kwd><kwd>цифровые технологии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>socially significant diseases</kwd><kwd>pharmaceutical care</kwd><kwd>high-cost nosologies</kwd><kwd>personalized medicine</kwd><kwd>digital technologies</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Воропинова О.А., Киселева И.Н., Нестеренко А.В. 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