farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLC10.17749/2070-4909/farmakoekonomika.2026.361farmaec-1380Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ ПУБЛИКАЦИИSynergism of magnesium- and pyridoxine-dependent proteins in nervous system support: systems biological analysisСистемно-биологический анализ синергизма магний- и пиридоксин-зависимых белков в контексте поддержки жизнедеятельности нервной системыhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич, к.ф-м.н., к.х.н.

WoS ResearcherID: C-7683-2018. Scopus Author ID: 7003300274

ул. Вавилова, д. 44, корп. 2, Москва 119333

Ivan Yu. Torshin, PhD

WoS ResearcherID: C-7683-2018. Scopus Author ID: 7003300274

44 bldg 2 Vavilov Str., Moscow 119333

https://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна, д.м.н., проф.

WoS ResearcherID: J-4946-2017. Scopus Author ID: 7003589812

ул. Вавилова, д. 44, корп. 2, Москва 119333

Olga A. Gromova, Dr. Sci. Med., Prof.

WoS ResearcherID: J-4946-2017. Scopus Author ID:  7003589812

44 bldg 2 Vavilov Str., Moscow 119333

unesco.gromova@gmail.comhttps://orcid.org/0009-0007-2744-4268РогозинМ. А.RogozinM. A.

Рогозин Михаил Александрович

Шереметевский пр-т, д. 8, Иваново 153012

Mikhail A. Rogozin

8 Sheremetevsky Ave., Ivanovo 153012

https://orcid.org/0000-0001-7507-191XГромовА. Н.GromovA. N.

Громов Андрей Николаевич

WoS ResearcherID: C-7476-2018. Scopus Author ID: 7102053964

ул. Вавилова, д. 44, корп. 2, Москва 119333

Andrey N. Gromov

WoS ResearcherID: C-7476-2018. Scopus Author ID: 7102053964

44 bldg 2 Vavilov Str., Moscow 119333

Федеральный исследовательский центр «Информатика и управление» Российской академии наукРоссияFederal Research Center “Computer Science and Control”, Russian Academy of SciencesRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Ивановский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияIvanovo State Medical UniversityRussian Federation202607052026119133156Copyright © Torshin I.Y., Gromova O.A., Rogozin M.A., Gromov A.N., 20262026Торшин И.Ю., Громова О.А., Рогозин М.А., Громов А.Н.Torshin I.Y., Gromova O.A., Rogozin M.A., Gromov A.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/1380

Background. For magnesium–pyridoxine therapy (original drug Magne B6®), the systems-level proteomic synergy of magnesium and pyridoxine-dependent proteins remains to be not sufficiently characterized in the nervous systems of pregnant women and diverse age groups.Objective: To establish the mechanisms of action of magnesium-dependent proteins on human neurophysiology and to characterize the proteomic synergy of original product components (a fixed combination of magnesium lactate and pyridoxine).Material and methods. In order to compile the most comprehensive list of magnesium- and pyridoxine-dependent proteins, the study applied algorithms for genome/proteome annotation and heterogeneous feature analysis, developed within the topological recognition theory. Subsequent analyses were conducted using data such as annotation keywords, protein tissue distribution, other protein cofactors, roles in the reactom, functional categories, protein interactions with various pharmaceuticals (including other micronutrients and nutraceuticals), and diseases associated with impaired magnesium-dependent protein activity.Results. The study identified a comprehensive set of magnesium- (n=1020) and pyridoxine-dependent (n=99) proteins, with a specific focus on those involved in nervous system function. Among various tissues, the brain exhibits the greatest diversity of magnesiumdependent (n=244) proteins. The synergy between magnesium and pyridoxine is manifested across many levels: cofactor interactions, protein functional categories, interactions with various pharmaceuticals, and associations with diseases. Notably, many pyridoxinedependent proteins interact with the same cofactors as magnesium-dependent proteins. Pyridoxine-dependent proteins generally fall into the same most common functional categories as magnesium-dependent ones, indicating a clear synergism between magnesium and pyridoxine in supporting fundamental physiological processes. At least 172 magnesium-dependent proteins and 20 pyridoxinedependent proteins in the human proteome are involved in the neuroprotective, neurotrophic, and other neurotropic effects of magnesium. These proteins play an important role in maintaining neurotransmitter homeostasis, neuroplasticity, and neuronal survival. Furthermore, a total of 143 drugs (including a number of micronutrients and/or nutraceuticals) are associated with the function/activity of magnesium-dependent proteins; these encompass anesthetics, anxiolytics, hypnotics and sedatives, antidementia drugs, calcium channel blockers, cardiac glycosides, antiarrhythmic agents and other cardiac drugs, antidepressants, antipsychotics, antibiotics, etc. The interaction of magnesium-dependent proteins with these groups of drugs is multidirectional. Analysis of diseases associated with dysfunction of magnesium-dependent proteins in the human proteome revealed at least 80 different diseases associated with magnesium deficiency (seizures; impaired fetal neurological development; myelination of nerves; impaired vision, hearing, and adaptive behavior; cognitive disorders; intellectual deficit). The majority of these pathologies linked to the dysfunction of magnesium-dependent proteins are also associated with the dysfunction of pyridoxine-dependent proteins. An extensive clinical evidence base has been established for the use of Magne B6® in neurology and neuropediatrics.Conclusion. The combination of organic magnesium salts (citrate, lactate, or pyroglutamate) with vitamin B6 in the Magne B6® product line (Magne B6® Forte, Magne B6® tablets, and Magne B6® oral solution) provides synergistic neuroprotective and mood-stabilizing effects. Evidence-based data confirm the pharmacological efficacy of the original drug Magne B6®.

Актуальность. Магний- и пиридоксин-зависимые белки протеома человека недостаточно исследованы на системно-биологическом уровне с точки зрения их синергидного воздействия на нервную систему беременных, пациентов разных возрастных групп при применении лекарственной формы комбинации органической соли магния и пиридоксина – оригинального препарата Магне В6®.Цель: установить механизмы воздействия магний- и пиридоксин-зависимых белков на нейрофизиологию человека и синергизма компонентов оригинального препарата, содержащего фиксированную комбинацию лактата магния и пиридоксина, на уровне протеома человека.Материал и методы. Алгоритмы аннотации геномов/протеомов и анализа разнородных признаковых описаний, разработанные в рамках топологической теории распознавания, были применены для получения наиболее полного списка магний- и пиридоксин-зависимых белков. Последующие анализы проведены с учетом следующих данных: ключевые слова аннотаций, распределение белков в тканях, другие кофакторы белков, реактомные роли белков, функциональные категории, взаимодействия белков с различными фармацевтическими препаратами (включая другие микронутриенты и нутрицевтики), а также заболевания, ассоциированные с нарушениями активности магний-зависимых белков.Результаты. Выявлены все возможные магний-зависимые (n=1020) и пиридоксин-зависимые (n=99) белки и отобраны белки, участвующие в функционировании нервной системы. Среди различных тканей именно головной мозг характеризуется наибольшим разнообразием магний-зависимых белков (n=244). Синергизм между магнием и пиридоксином проявляется на многих уровнях: взаимодействия с другими кофакторами, функциональные категории белков, взаимодействия с различными фармацевтическими препаратами и ассоциации с заболеваниями. Многие пиридоксин-зависимые белки взаимодействуют с теми же кофакторами, что и магний-зависимые. Пиридоксин-зависимые белки относились в основном к тем же наиболее часто встречающимся функциональным категориям, что и магний-зависимые, что указывает на очевидный синергизм магния и пиридоксина в поддержании фундаментальных физиологических процессов. В реализации нейропротекторных, нейротрофических и других нейротропных эффектов иона магния участвуют по крайней мере 172 магний-зависимых белка протеома человека и 20 пиридоксин-зависимых белков. И магний, и пиридоксин-зависимые белки важны для поддержания гомеостаза нейротрансмиттеров, нейропластичности и выживания нейронов. С функцией/активностью магний-зависимых белков ассоциированы 143 лекарственных препарата (в т.ч. ряд микронутриентов и/или нутрицевтиков), включая анестетики, анксиолитики, снотворные и седативные средства, препараты против деменции, блокаторы кальциевых каналов, сердечные гликозиды, антиаритмические средства и другие кардиопрепараты, антидепрессанты, антипсихотики, антибиотики и т.д. Взаимодействие магний-зависимых белков с указанными группами препаратов разнонаправленно. Анализ заболеваний, связанных с нарушениями функции магний-зависимых белков протеома человека, указал по крайней мере на 80 различных заболеваний, ассоциированных с дефицитом магния (судорожные состояния, нарушения неврологического развития плода, миелинизации нервов, ухудшение зрения, слуха, адаптивного поведения, когнитивные нарушения и интеллектуальный дефицит). Большинство патологий, ассоциированных с дисфункцией магний-зависимых белков, ассоциированы и с дисфункцией пиридоксин-зависимых белков. Накоплена обширная база клинических исследований применения препарата Магне В6® в неврологии и нейропедиатрии.Заключение. Комбинирование фармацевтических форм органических солей магния (цитрата, лактата или пироглутамата) с витамином В6 в линейке лекарственных препаратов Магне В6® (Магне B6® Форте, Магне B6® (таблетки), Магне B6® (питьевой раствор)) обеспечивает синергидный нейропротекторный и нормотимический эффект. Данные доказательной медицины подтверждают фармакологическую эффективность именно для оригинального лекарственного препарата Магне В6® в клинических исследованиях.

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The authors declare that there are no conflicts of interest present.