References

farmaec

FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology

ФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология

2070-49092070-4933

IRBIS LLC

10.17749/2070-4909/farmakoekonomika.2024.278

farmaec-1099

Research Article

REVIEW ARTICLES

ОБЗОРНЫЕ ПУБЛИКАЦИИ

Biosensors for measuring nitric oxide NO levels in biosubstrates: a systematic analysis

Биосенсоры для измерений уровней оксида азота NO в биосубстратах: систематический анализ

https://orcid.org/0000-0002-2659-7998

Торшин

И. Ю.

Torshin

I. Yu.

Торшин Иван Юрьевич, к.ф-м.н., к.х.н.

WoS ResearcherID: C-7683-2018.

Scopus Author ID: 7003300274.

ул. Вавилова, д. 44, корп. 2, Москва 119333.

Ivan Yu. Torshin, PhD (Phys. Math.), PhD (Chem.)

WoS ResearcherID: C-7683-2018.

Scopus Author ID: 7003300274.

44 corp. 2 Vavilov Str., Moscow 119333.

https://orcid.org/0000-0002-7663-710X

Громова

О. А.

Gromova

O. A.

Громова Ольга Алексеевна, д.м.н., проф.

WoS ResearcherID: J-4946-2017.

Scopus Author ID: 7003589812.

ул. Вавилова, д. 44, корп. 2, Москва 119333.

Olga A. Gromova, Dr. Sci. Med., Prof.

WoS ResearcherID: J-4946-2017.

Scopus Author ID: 7003589812.

44 corp. 2 Vavilov Str., Moscow 119333.

unesco.gromova@gmail.com

https://orcid.org/0000-0003-1541-9480

Майорова

Л. А.

Mayorova

L. A.

Майорова Лариса Александровна, д.ф.-м.н.

WoS ResearcherID: B-6288-2016.

Scopus Author ID: 58079684100.

ул. Вавилова, д. 44, корп. 2, Москва 119333; Шереметевский пр-т, д. 7, Иваново 153000.

Larissa A. Maiorova, Dr. Sci. Phys. Math.

WoS ResearcherID: B-6288-2016.

Scopus Author ID: 58079684100.

44 corp. 2 Vavilov Str., Moscow 119333; 7 Sheremetyevsky Ave., Ivanovo 153000.

https://orcid.org/0000-0001-7507-191X

Громов

А. Н.

Gromov

A. N.

Громов Андрей Николаевич

Scopus Author ID: 7102053964.

ул. Вавилова, д. 44, корп. 2, Москва 119333

Andrey N. Gromov

Scopus Author ID: 7102053964.

44 corp. 2 Vavilov Str., Moscow 119333.

Федеральный исследовательский центр «Информатика и управление» Российской академии наукРоссияFederal Research Center “Computer Science and Control”, Russian Academy of SciencesRussian Federation

Федеральный исследовательский центр «Информатика и управление» Российской академии наук; Федеральное государственное бюджетное образовательное учреждение высшего образования «Ивановский государственный химико-технологический университет»РоссияFederal Research Center “Computer Science and Control”, Russian Academy of Sciences; Ivanovo State University of Chemistry and TechnologyRussian Federation

2025

22012026

184560570

2026

Торшин И.Ю., Громова О.А., Майорова Л.А., Громов А.Н.

Torshin I.Y., Gromova O.A., Mayorova L.A., Gromov A.N.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.pharmacoeconomics.ru/jour/article/view/1099

Nitric oxide NO is a signaling molecule involved in numerous physical and pathological processes in biological systems. Highly sensitive sensor materials for measuring NO amounts in vivo in exhaled air and in body fluids (saliva, blood, urine) can be a useful tool in diagnostics and management of patients with bronchopulmonary, cardiovascular, neurological and tumor diseases. Several approaches to measuring NO in biosubstrates (including exhaled air) have been developed: fluorescence/chemiluminescence, electron spin resonance, electrochemical/amperometric (organic and inorganic) and enzymatic/protein sensors. Semiconductors, transition metal nitrides, phthalocyanine complexes, porphyrin and cobalamin derivatives with metals can serve as materials for NO sensors. Creating sensor materials based on vitamin B12 derivatives is an urgent research task in biomedicine. The article systematizes information on using various compounds as materials for NO-sensitive and selective sensors to measure/evaluate NO levels in various biosubstrates.

Оксид азота NO – сигнальная молекула, участвующая в многочисленных физических и патологических процессах в биологических системах. Высокочувствительные сенсорные материалы для измерения количеств NO in vivo в выдыхаемом воздухе и жидких средах организма (слюна, кровь, моча) могут быть полезным инструментом в диагностике и ведении пациентов с бронхолегочными, сердечно-сосудистыми, неврологическими и опухолевыми заболеваниями. Разработано несколько подходов к измерению NO в биосубстратах (включая выдыхаемый воздух) – флуоресценция/хемилюминесценция, электронный спиновый резонанс, электрохимические/амперометрические (органические и неорганические) и ферментативные/белковые сенсоры. Материалами для NO-сенсоров могут быть полупроводники, нитриды переходных металлов, комплексы фталоцианинов, производных порфирина и кобаламина с металлами. Создание сенсорных материалов на основе производных витамина В12 представляет собой актуальную исследовательскую задачу биомедицины. В статье систематизирована информация об использовании различных соединений в качестве материалов для NO-чувствительных и селективных сенсоров для измерения/оценки уровней NO в различных биосубстратах.

метаболиты оксида азотадиагностикатест-полоскисенсоры

nitric oxide metabolitesdiagnosticstest stripssensors

Работа выполнена при поддержке гранта Российского научного фонда No 20-12-00175-п на базе ФГБОУ ВО «Ивановский государственный химико-технологический университет».

The work was supported by the grant of the Russian Science Foundation No. 20-12-00175-p on the basis of Ivanovo State University of of Chemistry and Technology.

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The authors declare that there are no conflicts of interest present.