farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLC10.17749/2070-4909/farmakoekonomika.2024.247farmaec-1094Research ArticleREVIEW ARTICLESОБЗОРНЫЕ ПУБЛИКАЦИИCystatin C: factors affecting diagnostic and prognostic value in acute kidney injuryЦистатин С: факторы, влияющие на диагностическую и прогностическую ценность при остром повреждении почекhttps://orcid.org/0000-0002-0483-1050МагомедалиевМ. О.MagomedalievM. O.

Магомедалиев Магомедали Омарасхабович

ул. Маштакова, д. 4, Подольск 142110

ул. 2-я Брестская, д. 5, Москва 123056

Magomedali O. Magomedaliev

4 Mashtakov Str., Podolsk 142110

5 2nd Brestskaya Str., Moscow 123056

magomedalim@mail.ruhttps://orcid.org/0000-0002-0459-0488КорабельниковД. И.KorabelnikovD. I.

Корабельников Даниил Иванович, к.м.н., доцент 

ул. Маштакова, д. 4, Подольск 142110

ул. 2-я Брестская, д. 5, Москва 123056

Scopus Author ID: 7801382184.

Daniil I. Korabelnikov, PhD, Assoc. Prof.

4 Mashtakov Str., Podolsk 142110

5 2nd Brestskaya Str., Moscow 123056

Scopus Author ID: 7801382184

Федеральное государственное казенное учреждение «1586 Военный клинический госпиталь» Министерства обороны Российской Федерации; Автономная некоммерческая организация дополнительного профессионального образования «Московский медикосоциальный институт им. Ф.П. Гааза»Россия1586 Military Clinical Hospital; Moscow Haass Medical Social InstituteRussian Federation202405112024173376383Copyright © Magomedaliev M.O., Korabelnikov D.I., 20242024Магомедалиев М.О., Корабельников Д.И.Magomedaliev M.O., Korabelnikov D.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/1094

The level of serum and urinary cystatin C (CysC) can be modulated by some factors (weight, gender, age, ethnicity, smoking), diseases (sepsis, cardiovascular disease, diabetes mellitus, metabolic syndrome, obesity, hypo- and hyperthyroidism) as well as administration of glucocorticosteroids, but all of them do not affect its prognostic and diagnostic value in acute kidney injury (AKI). The CysC concentration can predict adverse outcomes, such as in-hospital and out-hospital mortality, chronicity of renal dysfunction, the demand and duration of renal replacement therapy (RRT). The sCysC is an independent predictor of RRT completion in critically ill AKI patients.

Некоторые факторы (масса тела, пол, возраст, этнос, табакокурение), заболевания (сепсис, сердечно-сосудистые патологии, сахарный диабет, метаболический синдром, ожирение, гипо- и гипертиреоз), а также прием глюкокортикостероидов оказывают влияние на концентрацию цистатина С (англ. cystatin C, CysC) в сыворотке крови и моче, но не влияют на его прогностическую и диагностическую ценность при остром повреждении почек (ОПП). По уровню CysC можно прогнозировать неблагоприятные исходы, такие как госпитальная и внегоспитальная летальность, хронизация почечной дисфункции, необходимость и длительность заместительной почечной терапии (ЗПТ). Показатель CysC является независимым предиктором завершения ЗПТ у критических больных с ОПП.

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The authors declare that there are no conflicts of interest present.