farmaecFARMAKOEKONOMIKA. Modern Pharmacoeconomics and PharmacoepidemiologyФАРМАКОЭКОНОМИКА. Современная фармакоэкономика и фармакоэпидемиология2070-49092070-4933IRBIS LLC10.17749/2070-4909/farmakoekonomika.2024.240farmaec-1012Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ ПУБЛИКАЦИИLignan 7-hydroxymatairesinol in the context of post-genomic pharmacologyЛигнан 7-гидроксиматаирезинол в контексте постгеномной фармакологииhttps://orcid.org/0000-0002-9639-2525РубашкинаА. Н.RubashkinaА. N.

Рубашкина Анна Николаевна – аспирант кафедры онкологии, акушерства и гинекологии 

Шереметевский пр-т, д. 8, Иваново 153012

Anna N. Rubashkina – Postgraduate, Chair of Oncology, Obstetrics and Gynecology

8 Sheremetyevsky Ave., Ivanovo 153012

https://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич – к.ф-м.н., к.х.н., старший научный сотрудник

WoS ResearcherID: C-7683-2018

Scopus Author ID: 7003300274

ул. Вавилова, д. 44, корп. 2, Москва 119333

Ivan Yu. Torshin – PhD (Phys. Math.), PhD (Chem.), Senior Researcher

WoS ResearcherID: C-7683-2018

Scopus Author ID: 7003300274

44 corp. 2 Vavilov Str., Moscow 119333

https://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна – д.м.н., профессор, ведущий научный сотрудник

WoS ResearcherID: J-4946-2017

Scopus Author ID: 7003589812

ул. Вавилова, д. 44, корп. 2, Москва 119333

Olga A. Gromova – Dr. Med. Sc., Professor, Leading Researcher

WoS ResearcherID: J-4946-2017

Scopus Author ID: 7003589812

44 corp. 2 Vavilov Str., Moscow 119333

unesco.gromova@gmail.comhttps://orcid.org/0000-0001-9679-632XГалустянА. Н.GalustyanA. N.

Галустян Анна Николаевна – к.м.н., доцент, заведующая кафедрой фармакологии с курсом клинической фармакологии и фармакоэкономики 

ул. Литовская, д. 2, Санкт-Петербург 194100

Anna N. Galustyan – MD, PhD, Associate Professor, Chief of Chair of Pharmacology with a Course in Clinical Pharmacology and Pharmacoeconomics

2 Litovskaya Str., Saint Petersburg 194100

Федеральное государственное бюджетное образовательное учреждение высшего образования «Ивановская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияIvanovo State Medical AcademyRussian FederationФедеральный исследовательский центр «Информатика и управление» Российской академии наукРоссияFederal Research Center “Computer Science and Control”, Russian Academy of SciencesRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSaint Petersburg State Pediatric Medical UniversityRussian Federation202415052024172191199Copyright © Rubashkina А.N., Torshin I.Y., Gromova O.A., Galustyan A.N., 20242024Рубашкина А.Н., Торшин И.Ю., Громова О.А., Галустян А.Н.Rubashkina А.N., Torshin I.Y., Gromova O.A., Galustyan A.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pharmacoeconomics.ru/jour/article/view/1012Objective

Objective: to determine the molecular mechanisms of action of 7-hydroxymatairesinol (7(OH)MR), the main lignan of spruce extracts, characterized by oncoprotective and anti-inflammatory properties.

Material and methods

Material and methods. The analysis of 7(OH)MR was carried out by chemoinformatic approach using the combinatorial theory of solvability and the topological theory of recognition. The postgenomic approach makes it possible to assess the effect of drugs on genome transcription (transcriptome) and on the proteome as a whole.

Results

Results. 7(OH)MP has anti-inflammatory (inhibition of 5-lipoxygenase, matrix metalloproteinase 2, mitogen-activated kinase p38-alpha, leukotriene В4 receptor, prostacyclin receptor), and oncoprotective (antioxidant effect due to inhibition of heme oxygenase-2, inhibition of cyclin-dependent kinases 3 and 4, epidermal growth factor, mTOR protein) pharmacological effects.

Conclusion

Conclusion. By reducing the expression of proliferative genes and genes involved in chronic inflammation, the 7(OH)MP molecule inhibits the proliferation of tumor cells. Pharmacoinformatic modeling showed that the anti-inflammatory effects of 7(OH)MR may contribute to increased lifespan in animal models.

Цель

Цель: определение молекулярных механизмов действия 7-гидроксиматаирезинола (7(ОН)МР) – основного лигнана экстрактов ели, характеризующегося онкопротективными и противовоспалительными свойствами.

Материал и методы

Материал и методы. Анализ 7(ОН)МР проведен на основе хемоинформационного подхода, использующего комбинаторную теорию разрешимости и топологическую теорию распознавания. Постгеномный подход позволяет оценивать действие лекарств на транскрипцию генома (транскриптом) и на протеом в целом.

Результаты

Результаты. 7(ОН)МР имеет противовоспалительные (ингибирование 5-липоксигеназы, матриксной металлопротеиназы 2, митоген-активируемой киназы 14, рецептора лейкотриена В4, рецептора простагландина) и онкопротективные (антиоксидантный эффект за счет ингибирования гемоксигеназы-2, ингибирование циклин-зависимых киназ 3 и 4, фактора роста эпидермиса, белка mTOR) фармакологические эффекты.

Заключение

Заключение. Снижая экспрессию пролиферативных генов и генов, вовлеченных в хроническое воспаление, молекула 7(ОН)МР тормозит пролиферацию опухолевых клеток. Фармакоинформационное моделирование показало, что противоспалительные эффекты 7(ОН)МР могут способствовать увеличению продолжительности жизни модельных животных.

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The authors declare that there are no conflicts of interest present.